Primary signet-ring cell carcinoma of the urinary bladder

Tanaka, Takuji; Kanai, Nobuyuki; Sugie, Shigeyuki; Nakamura, Atsuhiro; Hayashi, Hideji; Fujimoto, Yoshinori; Takeuchi, Toshimi

doi:10.1016/s0344-0338(87)80157-7

Cited by 10 publications

(4 citation statements)

References 10 publications

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“…11 Tanaka et al also reported effective treatment with systemic chemotherapy (MMC, PEP, CPM, VCR) and radiation therapy. 12 However, these two cases differed both in regimen and in method of injection. Therefore, we conclude that to improve the prognosis of primary signet-ring cell carcinomas of the urinary bladder, early diagnosis and establishing a regimen of chemotherapy is necessary.…”

Section: Discussionmentioning

confidence: 98%

“…In general, chemotherapy and radiotherapy have not been effective, 10 but Ota et al reported effective treatment with intra‐arterial chemotherapy (CDDP 50 mg/m 2 , MTX 30 mg/m 2 ) and radiation therapy 11 . Tanaka et al also reported effective treatment with systemic chemotherapy (MMC, PEP, CPM, VCR) and radiation therapy 12 . However, these two cases differed both in regimen and in method of injection.…”

Section: Discussionmentioning

confidence: 99%

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Primary signet‐ring cell carcinoma of the urinary bladder inducing renal failure

Yamamoto¹,

Ito²,

Akiyama³

et al. 2001

Int J of Urology

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A case of primary signet-ring cell carcinoma of the urinary bladder that was found to have induced renal failure is the second such case reported in the world. Primary signet-ring cell carcinoma of the urinary bladder is a rare histologic variant of adenocarcinoma. The patient died of distant metastasis 8 months after undergoing total cystectomy. The neoplasm had a high stage at diagnosis, so the prognosis was very poor. To improve the prognosis, earlier diagnosis and establishing a regimen of chemotherapy is necessary.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Primary signet‐ring cell carcinoma of the urinary bladder inducing renal failure

Yamamoto¹,

Ito²,

Akiyama³

et al. 2001

Int J of Urology

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“…Ota el al 12 reported effective treatment with intra-arterial chemotherapy with cisplatin and metotrexato and radiation therapy. Tanaka el al 13 also reported effective treatment with systemic chemotherapy and radiation therapy. Other authors have treated this tumours with radiotherapy after cystectomy 14 .…”

Section: Discussionmentioning

confidence: 99%

Primary signet-ring cell adenocarcinoma of the urinary bladder: a case report

Cobo-Dols¹,

Alcaide²,

Gutiérrez³

et al. 2006

Oncología (Barc.)

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SummaryPrimary signet-ring cell adenocarcinoma of the urinary bladder is a rare tumor. We report in this study the case of a 53 year old man consulting for gross hematuria. Computed tomography imaging demonstrated right hydronephrosis and an invasive bladder tumor. The bladder biopsy showed a signetring cell carcinoma; the exploration of the gastrointestinal tract did nor reveal any other tumor localization. A total cystoprostatectomy was performed followed by adjuvant chemotherapy with cisplatin and gemcitabine. The aim of this study is to determine the anatomoclinical, therapeutic and evolutionary characteristics of this rare tumor.

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“…Immunohistochemical analyses were conducted in several patients. The most common positive immunohistochemical markers were the Periodic acid-Schiff (PAS) (n = 18), Carcinoembryonic antigen (CEA) (n = 13), Epithelial membrane antigen (EMA) (n = 13) and Cytokeratin Cam 5.2 (n = 13) [13,[15][16][17]21,25,26,28,29,31,36,38,[40][41][42]. A summary of the immunohistochemical analyses can be found in Table 1.…”

Section: Diagnostic Procedures and Pathologic Findingsmentioning

confidence: 99%

Systematic Review: Seventy-Seven Cases of Signet Ring Cell Adenocarcinoma of the Bladder

Chew,

Boot,

Wilson

et al. 2024

SIUJ

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Background: Signet ring cell adenocarcinoma (SRCC) of the bladder is a rare and aggressive histological subtype of bladder cancer. Due to its infrequency, the understanding of its clinical behaviour, treatment strategies, and outcomes remains limited, being primarily derived from isolated case reports and series. Objective: To systematically review and analyse the available literature on SRCC of the bladder, emphasizing its clinical characteristics, diagnostic approaches, treatment modalities, and outcomes. Material and Methods: A comprehensive search was conducted across PubMed, Embase, and Medline following the PRISMA guidelines, including case reports, case series, observational studies, and clinical trials reporting on bladder SRCC. Results: We included 38 articles reporting on 77 patients, primarily males (79.2%), with a median age of 64 years. The most common presenting symptoms were haematuria (64.8%) and lower urinary tract symptoms (46.3%). All the diagnoses were based on histopathological examination of bladder tissue samples and immunohistochemistry. Mixed histological types of bladder cancer were found in 20.7% of cases, most commonly urothelial carcinoma (61.1%). The treatments varied, with 53.2% of patients undergoing radical cystectomy, 24.7% receiving radiotherapy, and 16.9% receiving chemotherapy. The five-year survival rates were 9.4%. Conclusion: Bladder SRCC presents aggressively, with varied treatment strategies; however, radical cystectomy appears to be the optimal means of surgical management for organ-confined disease. The overall survival rate is low, highlighting the need for further research to understand and manage this rare bladder cancer variant. All patients should undergo evaluation to exclude extravesical primaries. This systematic review contributes to a better understanding of this disease and may guide clinical management strategies.

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Primary signet-ring cell carcinoma of the urinary bladder

Cited by 10 publications

References 10 publications

Primary signet‐ring cell carcinoma of the urinary bladder inducing renal failure

Primary signet‐ring cell carcinoma of the urinary bladder inducing renal failure

Primary signet-ring cell adenocarcinoma of the urinary bladder: a case report

Systematic Review: Seventy-Seven Cases of Signet Ring Cell Adenocarcinoma of the Bladder

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