Primary salivary duct carcinoma of the lung, mucin-rich variant

A lung tumor with features of salivary duct carcinoma

“…With respect to histogenesis, all previously reported pulmonary SDCs, similar to other pulmonary SGTs, developed in the proximal bronchi (Supplementary Table S1), suggestive of origins from submucosal bronchial glands. 2 However, in our case, the tumor was located in the peripheral lung adjacent to the pleura.…”

“…Thereafter, two additional cases have been reported globally. 2,3 Summarizing these findings (Supplementary Table S1), the essential pathological features of pulmonary SDC are tubular/cribriform nests with comedo necrosis, positive AR and HER2 expression (and HER2/neu gene amplification by FISH), and negative TTF-1 expression. [1][2][3] Male and female seem equally predisposed, and smoking could be related to its development.…”

“…1 Their origin is considered to be the submucosal bronchial glands and their histological appearance is similar to that of SGTs developing in the head and neck region. 2 The most common histological types of pulmonary SGT are mucoepidermoid carcinoma and adenoid cystic carcinoma, in contrast to pleomorphic adenoma in head and neck SGTs. 1 Pulmonary salivary duct carcinoma (SDC) is extremely rare, with only three cases reported in the literature.…”

“…1 Pulmonary salivary duct carcinoma (SDC) is extremely rare, with only three cases reported in the literature. [1][2][3] Here, we present a case of pulmonary SDC that developed in a patient with interstitial pneumonia with reference of its histopathological and molecular pathological features.…”

Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature

“…Recently, a case of a primary pulmonary mucin-rich variant of salivary duct carcinoma with preoperative cytology was published: BAL revealed cytologic atypia, and the right upper lobe bronchial brushing was positive for carcinoma. However, ICC was not performed due to the paucity of diagnostic material and a conclusive diagnosis was not reached on cytological material (38). MASC, a rare salivary gland tumor first described in 2010, has never been described as a primary lung neoplasm (39).…”