A lung tumor with features of salivary duct carcinoma

Sato, Keisuke; Matsumura, Mai; Anzai, Yoko; Arai, Hiromasa; Sekiya, Motoki; Sugiyama, Misaki; Kataoka, Toshiaki; Koike, Chihiro; Ohashi, Kenichi; Okihara, Koji

doi:10.1111/pin.13072

Cited by 1 publication

(7 citation statements)

References 5 publications

(13 reference statements)

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“…Salivary duct carcinoma [24][25][26] À/+ 72 - two-tiered grading system of low and high grade based on mitotic activity, necrosis, and cytologic atypia. High-grade MEC of the lung is rare; it is characterized by greater cytologic atypia, more frequent mitotic figures, more common necrosis, and a predominance of the intermediate cell and squamoid cell components (Figure 2A-C).…”

Section: Limited Datamentioning

confidence: 99%

“…On immunohistochemistry, all three pulmonary salivary duct carcinomas were at least focally positive for GCDFP-15, Her2, and androgen receptor (AR), and were negative for TTF-1. 24 The differential diagnosis includes cribriformpredominant lung adenocarcinoma, a considerable proportion of which are TTF-1-negative (e.g. 17% in one study 191 ).…”

Section: S a L I V A R Y D U C T C A R C I N O M Amentioning

confidence: 99%

“…26 Salivary duct carcinoma primary to the head and neck is typically an aggressive neoplasm but has shown response to agents targeting HER2. 24,194,195 Therefore, the diagnosis of salivary duct carcinoma is important, as it may also have treatment implications in the lung.…”

Section: S a L I V A R Y D U C T C A R C I N O M Amentioning

confidence: 99%

“…Three cases of primary pulmonary salivary duct carcinoma have been reported, identified in patients 55–82 years of age 24–26 . Two of these tumours occurred in proximal bronchi and one was identified adjacent to the pleura, and in all cases metastatic disease was felt to be sufficiently excluded.…”

Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 99%

“…The most common types of pulmonary salivary gland-type carcinoma include mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (AdCC), and epithelial-myoepithelial carcinoma (EMC). 6,8,[10][11][12][13] Case reports and series have also described hyalinizing clear cell carcinoma (HCCC), 4,14,15 acinic cell carcinoma (AciCC), [16][17][18][19] secretory carcinoma, [20][21][22][23] salivary duct carcinoma, [24][25][26] intraductal carcinoma, 27,28 and polymorphous adenocarcinoma [29][30][31][32][33] occurring as primary lung tumours. Benign salivary gland-type tumours reported in the lung include myoepithelial tumours and pleomorphic adenomas.…”

Section: Introductionmentioning

confidence: 99%

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Recent developments in the pathology of primary pulmonary salivary gland‐type tumours

Naso,

Roden

2023

Histopathology

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Primary pulmonary salivary gland‐type tumours are rare neoplasms that are thought to arise from seromucinous glands that are located in the submucosa of large airways. These neoplasms have clinical and pathologic features that are distinct from other pulmonary neoplasms. The majority of primary pulmonary salivary gland‐type tumours are malignant, with the most common entities being mucoepidermoid carcinoma, adenoid cystic carcinoma, and epithelial‐myoepithelial carcinoma. Less commonly seen are myoepithelial carcinoma, hyalinizing clear cell carcinoma, acinic cell carcinoma, secretory carcinoma, salivary duct carcinoma, intraductal carcinoma, and polymorphous adenocarcinoma. Benign salivary gland‐type tumours of the lung include pleomorphic adenoma and sialadenoma papilliferum. Morphologic, immunophenotypic, and molecular features of these neoplasms are largely similar to salivary gland tumours elsewhere, and therefore the exclusion of metastatic disease requires clinical and radiologic correlation. However, the differential diagnostic considerations are different in the lung. The distinction of salivary gland‐type tumours from their histologic mimics is important for both prognostication and treatment decisions. Overall, salivary gland type‐tumours tend to have a more favourable outcome than other pulmonary carcinomas, although high‐grade variants exist for many of these tumour types. Recent advances in our understanding of the spectrum of salivary gland‐type tumours reported in the lung and their diversity of molecular and immunohistochemical features have helped to refine the classification of these tumours and have highlighted a few differences between salivary gland‐type tumours of the lung and those primary to other sites.

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Section: Limited Datamentioning

confidence: 99%

Section: S a L I V A R Y D U C T C A R C I N O M Amentioning

confidence: 99%