Primary Rhabdomyosarcoma of the Breast in a 13-Year-Old Girl: Report of a Case

Nogi, Hiroko; Kobayashi, Tadashi; Kawase, Kazumi; Tabei, Isao; Toriumi, Yasuo; Suzuki, Masafumi; Kawakami, Makio; Morikawa, Toshiaki; Uchida, Keiji

doi:10.1007/s00595-006-3326-2

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…All patients with breast metastasis from RMS also had an alveolar histology and were adolescent girls [7]. The primary breast RMS lesions were bilateral in 2 cases [14,21], and regional lymph node involvement was present in 4 patients [8,10,11,12]. RMS cases with bilateral breast metastasis have been reported to account for less than 25%, while metastatic lymph nodes have been encountered in 25-58% [24,7].…”

Section: Discussionmentioning

confidence: 99%

“…Breast involvement is very rare, both as a primary or as a metastatic site [7]. Only a few cases of primary RMS of the breast in children have been reported in the literature (table 1) [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22]. Due to the extremely rare incidence of primary breast RMS, radiologic imaging features have yet to be clearly defined.…”

Section: Introductionmentioning

confidence: 99%

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Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review

et al. 2018

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Background: Primary breast rhabdomyosarcoma (RMS) can occur in children. There is a lack of knowledge regarding radiologic findings and added diffusion-weighted magnetic resonance imaging (MRI) features of RMS in the literature. Case Report: A 12-year-old girl was diagnosed with primary alveolar RMS of the breast. Gray scale ultrasound revealed posterior acoustic enhancement behind a well-circumscribed, multilobulated hypoechoic mass. Doppler ultrasound revealed increased peripheral and central vascularity. Hypointense septations on T2-weighted image exhibiting more enhancement than the stroma on late gadolinium-enhanced images were striking within a hyperintense mass. A hyperintense hemorrhagic focus on T1-weighted image was present in the absence of any necrosis. Avid enhancement on early postcontrast images proceeding from the periphery to the center was depicted. Conclusion: A rapidly enlarging mass with an echogenic peripheral rim together with posterior acoustic enhancement on gray scale ultrasound, intense vascularity on Doppler ultrasound, axillary lymphadenopathy, and satellite nodules on MRI should raise suspicion. Enhancing central and peripheral septations are suggestive of RMS. Dynamic contrast-enhanced MRI in suspected cases can provide valuable data in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review

et al. 2018

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“…The standard regimens of chemotherapy that are currently used for embryonal rhabdomyosarcoma are vincristine, actinomycine, and cyclophosphamide (VAC), or vincristine, actinomycin, and ifosfamide (VAI). At the present time there is no established chemotherapy protocol for alveolar rhabdomyosarcoma, and thus, surgery plays a significant role in the treatment of these patients 24 . The NUTOS cell line could be very important in helping to establish regimens that could be used to treat rhabdomyosarcoma in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

“…At the present time there is no established chemotherapy protocol for alveolar rhabdomyosarcoma, and thus, surgery plays a significant role in the treatment of these patients. 24 The NUTOS cell line could be very important in helping to establish regimens that could be used to treat rhabdomyosarcoma in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs

et al. 2010

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Primary alveolar type of rhabdomyosarcoma (RMS) tumor tissue was collected from the tongue of a 17-year-old Japanese woman and used to successfully establish a rhabdomyosarcoma cell line, which has been designated NUTOS. The chromosomal distribution revealed that the NUTOS cell line was hyper-tetraploid with chromosomal translocation. The cells were grown in Dulbecco's modified eagle medium/F12 supplemented with 15% fetal bovine serum, 0.1% non-essential amino acids solution (NEAA), 50 microg of streptomycin, 50 U/mL of penicillin and 0.25 microg /mL of Fungizone. The NUTOS shapes included small spindles, large spindles and long, thick multinucleated cells. All three cell types were immunostained with anti-desmin antibody, which is a marker protein for middle sized myofilaments. Furthermore, immunocytochemical staining revealed that the cells were positively immunostained with anti-MyoD, myogenin, alpha-sarcomeric actin, myosin and troponin T. Mitotic figures were only observed in the small spindle cells. These cells were coadunated with each other at the lateral portion of the apex of the cells. Subsequently, these cells grew into large multinucleated cells. Autonomic contractions (approximately 20 times/min) were observed in both the large spindle cells and the large multinucleated cells. NUTOS cells incorporated serotonin from the serum in the growth medium. Histopathological observations of the NUTOS cell grafts in the subcutis of nude mice exhibited characteristics similar to those seen for the primary rhabdomyosarcoma of the tongue. Susceptibility tests for the anti-cancer drugs revealed that NUTOS cells were susceptive to cisplatin, paclitaxel, and docetaxel, but not to adriacin.

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“…Some alveolar RMS cell lines have been established and their characteristics have been investigated 5,6 . Thus, experiments of in vitro differentiation of alveolar RMS cells using retinoic acid have been reported 7–10 . Some of these reports showed evidence of morphological and/or myogenic differentiation using retinoic acid in alveolar RMS cells 8–10 .…”

Section: Introductionmentioning

confidence: 99%

Characterization, anticancer drug susceptibility and atRA-induced growth inhibition of a novel cell line (HUMEMS) established from pleural effusion of alveolar rhabdomyosarcoma of breast tissue

Ohi

2007

Human Cell

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We recently established a cell line derived from pleural effusion from a 13-year-old girl with primary alveolar rhabdomyosarcoma (RMS with a chromosomal translocation t[2;13]) in the breast tissue. The cell line was designated as HUMEMS. Cases of primary alveolar RMS swelling in the breast are extremely rare (about 0.2% of all RMSs). Therefore, the HUMEMS cell line is an important material for studying therapeutics for malignant tumors in children. The HUMEMS cell line we isolated consisted of two morphological subtypes. One type (SSN cells) is small in size and has a single nucleus. Another (LMN cells) is large in size and has two or more nuclei. Both SSN cells and LMN cells were immunohistochemically positive for desmin and slightly positive for myoglobin. Our data suggested LMN cells are well-differentiated SSN cells. Moreover, in some of the LMN cells, rapid cell contractions (1-5 times/10 sec) were observed. We investigated the anticancer drug susceptibility of the HUMEMS cell line with an oxygen electrode apparatus (Daikin, DOX-10, JPN) and effect of all-trans-retinoic acid (atRA) to the cell line. The atRA-treatment inhibited proliferation of the HUMEMS cells.

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Primary Rhabdomyosarcoma of the Breast in a 13-Year-Old Girl: Report of a Case

Cited by 11 publications

References 7 publications

Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review

Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review

Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs

Characterization, anticancer drug susceptibility and atRA-induced growth inhibition of a novel cell line (HUMEMS) established from pleural effusion of alveolar rhabdomyosarcoma of breast tissue

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