Primary reticulum cell sarcoma of bone. With emphasis on radiation therapy

Wang, C. C.; Fleischli, Donald J.

doi:10.1002/1097-0142(196811)22:5<994::aid-cncr2820220514>3.0.co;2-v

Cited by 83 publications

(12 citation statements)

References 5 publications

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“…Previous publications have not always stated the frequency of distant relapse in patients achieving loco-regional control, but where reported, the rate after local therapy alone ranges from 22-38% (Mendenhall et al, 1987;Wang et al, 1968). In our own series 58% of the XRT alone group experienced distant relapse (with loco-regional control) within 5 years of treatment.…”

Section: Discussionsupporting

confidence: 89%

“…Our results suggest that large disease bulk (present in two out of three relapses) is an important risk factor for local failure after XRT alone, a finding in common with our previous reports of radiation for localised NHL (Gospodarowicz et al, 1987;Sutcliffe et al, 1985). Doses of XRT reported in other series have generally been higher with some claims for a dose response relationship (Dosoretz et al, 1983;Wang et al, 1968). Our data did not show evidence for such a relationship and indeed the three patients with in-field failure after XRT alone all received doses higher than the median of 35Gy.…”

Section: Discussionmentioning

confidence: 99%

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Localised lymphoma of bone: prognostic factors and treatment recommendations

Rathmell

Gospodarowicz²,

Sb³

et al. 1992

Br J Cancer

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SummaryTwenty seven adult patients with newly diagnosed non-Hodgkin's lymphoma localised to either bone (Stage IE) or bone and regional lymph nodes (Stage IIE) were treated between 1967 and 1988. Median age was 53 years and the commonest histology (21 patients) was diffuse histiocytic lymphoma. Twenty-four patients were treated radically: 15 with radiation therapy (XRT) alone and nine with chemotherapy plus radiation therapy (CMT). The cause specific survival for these patients was 56% at 5 years and 40% at 10 years. Survival was significantly better for patients treated by CMT (88% at 5 years) as compared to XRT alone (40% at 5 years, P = 0.03) and for age <60 (72% at 5 years) compared to > 60 (30% at 5 years, P = 0.018). Relapse-free rate was 27% at 5 years with XRT alone and 89% with CMT (P = 0.01). Risk factors for loco-regional relapse (seven cases) included: large tumour bulk, treatment by XRT alone and use of 'limited' radiation fields. No radiation dose-response relationship could be identified in this study. Long term local control and survival for localised lymphoma of bone were excellent after treatment by CMT but XRT alone was associated with unacceptably high local and distant failure rates.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Localised lymphoma of bone: prognostic factors and treatment recommendations

Rathmell

Gospodarowicz²,

Sb³

et al. 1992

Br J Cancer

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“…Due to the relative infrequency of regional metastases, the advisability of elective nodal irradiation is doubtful; however, the regional lymphatic drainage areas should be irradiated from the mastoid process to the supraclavicular area if lymphnode involvement (Stage II) is present. DISCUSSION Although our series was relatively small, this study lends further support to the growing recognition that extranodal malignant lymphomas such as those arising primarily from the bone, Waldeyer's ring, and larynx are often radiocurable (1)(2)(3)(4)(5)(6). For Stages I and II, aggressive radiation therapy is the treatment of choice.…”

supporting

confidence: 70%

Primary Malignant Lymphoma of the Oral Cavity and Paranasal Sinuses

Wang¹

1971

Radiology

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The clinical course, radiotherapeutic management, and results of studies of 37 patients with extranodal malignant lymphoma arising from the oral cavity and paranasal sinuses are presented. When the disease is localized, fiveyear survival rates of 65% (15 of 23 patients) for Stage I lesions and 33% (2 of 6 patients) for Stage II lesions have been realized. The author suggests a hopeful attitude and aggressive approach to this disease.

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“…survival figure 15. The extranodal lym¬ phomas are peripherally grouped9·1ß within the classification of tumors involving the reticuloendothelial sys¬ tem and, perhaps, lymph node region or single extranodal site (Ie) Stage II: Two or more lymph node regions on same side of diaphragm (II) or extranodal site and one or more lymph node regions on same side of diaphragm (He) Stage III: Lymph node regions on both sides of diaphragm; may also be accompanied by extranodal site…”

mentioning

confidence: 44%