Primary reticulosis of the central nervous system ?microgliomatosis?

The clinical diagnosis and treatment of microgliomatosis: report of a case.

“…In an attempt to establish the diagnostic criteria of microgliomatosis we have reviewed 56 cases reported in the literature in which sufficient clinical data are available and the diagnosis had been adequately confirmed histologically (Yuile, 1938;Kinney and Adams, 1943;Russell et al, 1948;Losli, 1956; Cervos Navarro, 1957;Fisher, Davis, and Lemmen, 1959;Kernohan and Uihlein, 1962;Miller and Ramsden, 1963;Rubinstein, 1964;Adams and Jackson, 1966;Barnard, 1968;Miller, 1968;personal communication).…”

“…In these cases it was suggested retrospectively that the cells could well have been microglial rather than lymphocytes (Miller and Ramsden, 1963). The ultimate diagnosis must rest on histological identification of the tumour in a biopsy specimen.…”

“…The spinal cord may be involved in some cases (Miller and Ramsden, 1963). It was obvious that treatment of the whole brain was essential; it was, however, debatable whether to include the cord in this field.…”

“…or primary reticulosis of the brain (Miller and Ramsden, 1963) is usually considered a pathological curiosity and the diagnosis has almost invariably been made on necropsy material. Yet the structure of the tumour suggests that it may be radiosensitive and every effort should therefore be made to reach a diagnosis during life.…”

Microglioma with paraproteinaemia

“…The clinical features of this uncommon tumour together with discussions of nomenclature and definition have been reported in several papers (Adams and Jackson, 1963;Burnstein et al, 1963;Miller and Ramsden, 1963;Rubenstein, 1964;Schaumburg et al, 1972). Little attention, however, has been paid to biochemical abnormalities in this condition.…”