The clinical diagnosis and treatment of microgliomatosis: report of a case.

Lymphomatosis cerebri as a cause of white matter dementia

“…This patient showed some therapeutic responses to cranial radiation therapy before he died 2 months later; no autopsy was performed [31]. This group foreshadowed the btake-home messageQ of our report when they cautioned their readers that bthe diagnosis has almost invariably been made on necropsy material.…”

“…Fisher et al in 1969 highlighted a rare premortem diagnosis in a patient who presented with dysphagia and dementia and was found to have diffusely infiltrating PCNSL on needle biopsies [31]. This patient showed some therapeutic responses to cranial radiation therapy before he died 2 months later; no autopsy was performed [31].…”

“…This group foreshadowed the btake-home messageQ of our report when they cautioned their readers that bthe diagnosis has almost invariably been made on necropsy material. Yet, the structure of the tumour suggests that it may be radiosensitive and every effort should therefore be made to reach a diagnosis during lifeQ [31]. Even in 1969, despite the limited technology of the time and the rarity of premortem diagnosis, Fisher et al implied the recognition of this pattern of PCNSL was not only a concern for the autopsy pathologist but should extend to the neurologist, radiologist, or surgical pathologist caring for the patient [31].…”

“…Yet, the structure of the tumour suggests that it may be radiosensitive and every effort should therefore be made to reach a diagnosis during lifeQ [31]. Even in 1969, despite the limited technology of the time and the rarity of premortem diagnosis, Fisher et al implied the recognition of this pattern of PCNSL was not only a concern for the autopsy pathologist but should extend to the neurologist, radiologist, or surgical pathologist caring for the patient [31]. It is only fair to say, however, that with the advent of sensitive premortem neuroimaging, we have become breacquaintedQ with various aspects of the biology of disease that were formerly well known to autopsy pathologists and neuropathologists.…”

Neuroradiological features of lymphomatosis cerebri: A systematic review of the English literature with a new case report

“…An understanding of the neuroradiological characteristics of lymphomatosis cerebri has yet to be resolved. The histopathological pattern of diffusely infiltrating microgliomatosis (PCNSL) was first described by the case report of Fisher et al ( 52 ) in 1969. Gross pathological sections of primary reticulum cell sarcoma of the brain (PCNSL) involved diffusely in the white matter were shown by Schaumburg et al ( 53 ) in 1972.…”