Primary Renal Neuroblastoma in Adults

Tiu, Albert; Latif, Edward; Yau, L.; Reynolds, Roisin; Millar, Ewan K.A.; Aslan, Peter

doi:10.1016/j.urology.2013.03.027

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…Due to the lack of specific guidelines, the treatment of adult renal neuroblastoma is based mostly on the recommendations for neuroblastoma in children. According to all published cases, 3 , 4 , 5 , 6 , 7 , 9 , 10 treatment modalities are surgery alone, or surgery plus adjuvant therapy (chemotherapy or radiotherapy). Huang and colleagues presented the case of a 41-year-old female with stage 4 neuroblastoma.…”

Section: Discussionmentioning

confidence: 99%

Adult renal neuroblastoma: A case report

Cissé,

Ndiaye,

Niang

et al. 2023

Urology Case Reports

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Section: Discussionmentioning

confidence: 99%

Adult renal neuroblastoma: A case report

Cissé,

Ndiaye,

Niang

et al. 2023

Urology Case Reports

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“…To the best of our knowledge, the youngest recorded patient with a neuroblastoma was 30 weeks old (4) and the oldest patient was 79 years old (5). A recent study found that the incident rate of neuroblastoma (80 per 1 million individuals) ranked first highest and that the 5-year survival rate (93.4%) was ranked third highest, amongst all types of cancer in the 309 cases of diagnosed cancer between 1998 and 2007 (6).…”

Section: Discussionmentioning

confidence: 99%

Surgical resection and post-operative radiotherapy in an adult renal neuroblastoma patient with multiple bone and joint metastases: A case report

Liu¹,

Liang²,

Ou³

et al. 2015

Oncology Letters

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Abstract. Renal neuroblastoma is uncommon, particularly in adults, with only a few cases having been reported in studies published in the English language. The incidence is only 0.12 cases/1 million individuals in those aged >20 years. Studies of the pathogenesis, biological characteristics, treatment and prognosis of renal neuroblastoma are limited due to this low incidence. The present study reports the case of a 22-year-old adult female who was diagnosed with a left renal neuroblastoma by computed tomography (CT), bone scan and pathological examination. The patient underwent a left nephroureterectomy, ipsilateral lymph node dissection and post-operative radiotherapy, prior to discharge 60 days after admittance. At the nine-month follow-up examination, the patient showed no evidence of recurrence, progression or metastatic disease on the CT scans of the chest, abdomen and pelvis. Renal neuroblastoma is extremely uncommon in adults. The diagnosis and treatment of renal neuroblastoma is complicated by the overall low incidence, lack of specific treatment guidelines, advanced disease state due to late presentation, and its associated co-morbidities. Further study of the pathogenesis, biological and clinical characteristics, and treatment of renal neuroblastoma is required to provide an optimal treatment for patients and to improve the patient's quality of life. IntroductionNeuroblastoma is the most common extracranial solid tumor to occur during childhood. The cancer arises in the sympathetic nervous system and mainly affects the adrenal glands and retroperitoneum, with a distribution pattern that is similar in children and adults. In total, >90% of the tumors are diagnosed in children <10 years old (1). The incidence in those >20 years old has been reported to be only 0.12 cases/1 million individuals (2). Renal neuroblastomas are extremely uncommon, particularly in adults. To the best of our knowledge, to date only one case of adult intrarenal neuroblastoma has been reported in the literature (3). The number of studies on the pathogenesis, biological characteristics, treatment and prognosis of the cancer have been limited due to this low incidence. The present study reports a case of left renal neuroblastoma in an adult patient with multiple bone and joint metastases, and discusses its clinical manifestations, diagnosis and treatment. Written informed consent was obtained from the patient's family. Case reportIn December 2013, a 22-year-old female was admitted to the Affiliated Hospital of Guangdong Medical College (Zhanjiang, China)with abdominal and joint pain that had been present for >10 days. There was no significant medical history. The patient had experienced no fever, chills, diarrhea, nausea, vomiting or hematuria. A physical examination revealed that the abduction, internal rotation and extension of the left shoulder and hip were limited. Computed tomography (CT) of the abdomen and pelvis showed a large heterogeneous and centrally necrotic mass, measuring 8.2x7.3x3.1 cm, in the upper pole of the left k...

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“…Until systemic chemotherapy proves curative, our approach is to recommend surgical resection following neoadjuvant therapy to patients with NB/GNB. Given that fewer than 100 cases of adult-onset NB/GNB have been described in the English-language literature, it is not surprising that treatment recommendations usually follow pediatric guidelines [1,7]. Although our bias has leaned toward chemotherapy and surgical resection, accepted treatment options consist of any combination of radiotherapy, chemotherapy, and surgery depending on tumor stage, patient age, and biologic prognostic factors [13].…”

Section: Discussionmentioning

confidence: 99%

“…When an NB is foun dinanadult,itusuallyisclassifiedasahigh-risktumor and is associated with a poor prognosis [4]. In the medical literature, the majority of reported adult-onset NBs are described in case reports or small case series, highlighting the rarity of this neoplasm [1,2,[5][6][7]. The aim of this study was to review our institutional experience of all adult patients with an NB or ganglioneuroblastoma (GNB) over a 30-year period with hopes of identifying prognostic factors, best treatment options, and more accurate survival data.…”

Section: Introductionmentioning

confidence: 99%