Review of Our Experience With Neuroblastoma and Ganglioneuroblastoma in Adults

Jrebi, Nezar; Iqbal, Corey W.; Joliat, Gaëtan‐Romain; Sebo, Thomas J.; Farley, David R.

doi:10.1007/s00268-014-2682-0

Cited by 25 publications

(29 citation statements)

References 19 publications

(16 reference statements)

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“…In spite of significant advances in detection and effort to reduce recurrence rates, the prognosis of NB remains poor. The predominant obstacle of NB therapy is recurrence, which is characterized by metastasis (1,2). Therefore, it is urgent to identify the molecular mechanism involved in NB metastasis.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68

Zhao

Tian

et al. 2015

Molecular Medicine Reports

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Abstract. Neuroblastoma (NB) is the most common solid extracranial tumor in children. However, the molecular mechanism of NB remains to be elucidated. In the present study, reverse transcription quantitative polymerase chain reaction data demonstrated that the expression of Sam68 was significantly upregulated in NB tissues compared with their matched adjacent normal tissues. Furthermore, it was revealed that reduced expression of miR-203 and increased expression of Sam68 co-existed in NB tissues. Knockdown of Sam68 reduced the proliferation, migration and invasion of human SK-N-SH and SH-SY5Y NB cells. Similarly, overexpression of miR-203 also inhibited the proliferation, migration and invasion of these two cell lines. It was further demonstrated that the protein expression level of Sam68 was negatively mediated by miR-203 in the SK-N-SH and SH-SY5Y NB cells. Additionally, data from a dual luciferase reporter assay confirmed that miR-203 directly targeted Sam68 by binding to its 3'-untranslated region. In conclusion, the present study suggested for the first time, to the best of our knowledge, that the aberrant downregulation of miR-203 may contribute to the aberrant upregulation of Sam68 in NB and that miR-203 has an inhibitory role in malignant progression of NB by targeting Sam68. The present study provided evidence to support miR-203/Sam68 as a novel diagnostic or therapeutic targets for NB.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68

Zhao

Tian

et al. 2015

Molecular Medicine Reports

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“…Previously, no patients with stage IV GNB have been reported to live beyond 5 years after diagnosis 3, 4.…”

Section: Discussionmentioning

confidence: 99%

Hitherto unseen survival in an ALK‐positive‐patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine

Risum

Knigge

Langer

2017

Clinical Case Reports

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“…[4] Most NBs secrete catecholoamines in the form of vanillylmandelic acid (VMA) and homovanillic acid (HVA). [3] Since 90 percent of patients have MIBG-avid disease, radioiodine-labeled MIBG is used to pinpoint primary tumors and metastatic sites in order to help stage the nueroblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…[14] It also becomes harder to detect or stage the NB due to the fact that MIBG is less useful as age increases. [4,14] Since little research has been done on adult NB, no standardized method of treatment has been formulated and pediatric protocols are typically followed. [4,13,15] In children, multidisciplinary treatment has been the standard of care and includes surgical resection, chemotherapy, radiation, and stem cell transplantation dependent on the stage of disease.…”

Section: Discussionmentioning

confidence: 99%

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Ganglioneuroblastoma in an adult patient

Monsma

Wright

Chung

2015

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Neuroblastoma (NB) is a common tumor in children but is extremely rare in adults. Sparse literature exists on adult NB or the subtype ganglioneuroblastoma (GNB). We present a 40-year-old male complaining of decreased strength and pain in his left hand. Imaging studies showed a paraspinal tumor at T1 and an abdominal mass while laboratory tests were significant for high plasma and urine metanephrines suggesting a diagnosis of pheochromocytoma. Percutaneous core needle biopsy was performed and a diagnosis of GNB was made based on immunohistochemical staining. The patient underwent debulking surgery and final pathology confirmed the diagnosis. The patient demonstrates no signs of local recurrence but developed diffuse bony metastasis after the debulking procedure. Systemic therapy regimens for GNB are largely extrapolated from pediatric regimens and efficacy is unknown. Differentiation between adult and pediatric NB remains unclear.

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Review of Our Experience With Neuroblastoma and Ganglioneuroblastoma in Adults

Abstract: Adult-onset NB/GNB is rare. Symptoms appear to occur later when incurable stage IV disease is detected. Complete surgical resection can lead to long-term, disease-free survival in stage I patients.

Cited by 25 publications

References 19 publications

MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68

MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68

Hitherto unseen survival in an ALK‐positive‐patient with advanced stage adult ganglioneuroblastoma treated with personalized medicine

Ganglioneuroblastoma in an adult patient

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