“…Aggressive chemotherapy regimens with or without radiotherapy, preferably per formed at full dose with haematopoietic grow factors, are regarded as the most effec tive treatment of NHL. even in the presence of renal extension [5][6][7], but relapse is fre quent and long-term patient survival re mains poor [8,9], In our observation, the patient was apparently free of the disease 26 months after the beginning of treatment but, in contrast with other reports in the lit erature [4][5][6], renal function did not im prove, possibly as a consequence of the se vere associated cell interstitial infiltrate. Considering these favourable initial results, we suggest the need for repeated and/or echo-guided renal biopsy in the presence of acute renal failure with enlarged kidneys, and the efficiency of high-dose chemothera py in high-grade NHL complicated by renal failure.…”
contrasting
confidence: 85%
“…Lymphomatous infiltration of the kidneys is a rare presetting manifestation of NHL. especially when responsible for acute or rapidly pro gressive renal failure [3][4][5]. It was suspected in our case because of morphological data KARGER, but was diagnosed only on the second biop sy.…”
“…Aggressive chemotherapy regimens with or without radiotherapy, preferably per formed at full dose with haematopoietic grow factors, are regarded as the most effec tive treatment of NHL. even in the presence of renal extension [5][6][7], but relapse is fre quent and long-term patient survival re mains poor [8,9], In our observation, the patient was apparently free of the disease 26 months after the beginning of treatment but, in contrast with other reports in the lit erature [4][5][6], renal function did not im prove, possibly as a consequence of the se vere associated cell interstitial infiltrate. Considering these favourable initial results, we suggest the need for repeated and/or echo-guided renal biopsy in the presence of acute renal failure with enlarged kidneys, and the efficiency of high-dose chemothera py in high-grade NHL complicated by renal failure.…”
contrasting
confidence: 85%
“…Lymphomatous infiltration of the kidneys is a rare presetting manifestation of NHL. especially when responsible for acute or rapidly pro gressive renal failure [3][4][5]. It was suspected in our case because of morphological data KARGER, but was diagnosed only on the second biop sy.…”
“…Lymphoma infiltration may affect the kidneys either primarily or secondarily [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Other studies have reported a frequency of kidney involvement ranging from 0.8 to 49% [2,12,13,14, 17].…”
Section: Discussionmentioning
confidence: 99%
“…Renal involvement as the only site (primary renal lymphoma) is a rare entity [3,4,5,6,7,8,9,10]. Usually, renal infiltration is reported as a consequence of advanced disease [11,12,13,14,15].…”
Objective: To evaluate renal involvement in childhood lymphoma and define its prognostic effects. Patients and Methods: One hundred and four patients with non-Hodgkin’s lymphoma and renal involvement on admission to a single center between 1972 and 2003 were evaluated retrospectively. Blood urea nitrogen, serum creatinine, uric acid, electrolytes, and lactate dehydrogenase levels, as well as urinalysis, were evaluated. One or more of the following imaging methods were performed: intravenous urogram, ultrasound, computed tomography, and magnetic resonance imaging. The χ2 test was used to compare the groups. The Kaplan-Meier survival method was used to calculate survival rates, and the log-rank test was used to compare groups with respect to survival. Survival rates were also compared in two different time periods (before 1991 and after 1991). Results: There were 76 boys and 28 girls with a median age of 6 (0.9–16) years. The renal infiltration pattern was nodular in 62 patients (59.6%) and diffuse in 40 patients (38.5%). Two patients had tumoral masses that originated from their kidneys (1.9%). Renal involvement was bilateral in 75 patients (72.1%); the remaining 29 patients had unilateral involvement. The overall survival rate was 42.5% with a median follow-up of 64 months. The factors that had a statistically significant impact on survival were high creatinine (p = 0.00001) and blood urea nitrogen levels (p = 0.0001), the onset of tumor lysis syndrome (p = 0.01), and the need for dialysis (p = 0.009). The survival rate was higher in the time period after 1991 (p = 0.01). Conclusion: Impaired renal function is a poor prognostic factor for non-Hodgkin’s lymphoma. Renal function should therefore be monitored closely. Renal dysfunction caused by direct tumoral involvement may complicate therapy and shorten survival.
“…Truong и соавт. [31] описали клинико-морфологическую картину первичной лимфомы почки у 51 пациента. Лимфоидная инфиль-трация почек наблюдалась у всех больных, но только у 15 отмечено развитие ОПН.…”
Section: поражение почек при злокачественных лимфопролиферативных забunclassified
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