Primary radiotherapy for subglottic carcinoma

Haylock, Brian; Deutsch, G.P.

doi:10.1016/s0936-6555(05)80310-3

Cited by 16 publications

(15 citation statements)

References 11 publications

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“…Considering the aggressive nature of this tumor, the incidence of cervical lymphadenopathy at presentation has been low. Rates of 4.0%, 28 4.3%, 10 9.3%, 29 and 14% 30 have been reported. In this series, 21.4% of patients with epidermoid cancer had detectable nodal disease.…”

Section: Discussionmentioning

confidence: 99%

Primary Subglottic Cancer

et al. 1998

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This retrospective study reviews 39 patients with primary subglottic cancer seen between 1955 and 1988 by the Department of Otolaryngology at Washington University. This number constitutes 1.8% of laryngeal cancer cases diagnosed during this period. Twenty-eight patients (71.8%) had epidermoid cancer, of which 19 (67.9%) had "early" disease (stages I and II), and nine (32.1%) had "advanced" (stages III and IV). Overall 5-year survival was 57.7%. Disease-free survival was 46.2%. Patients treated with radiotherapy alone, surgery alone, or both had disease-free 5-year survivals of 22.2%, 41.7%, and 100%, respectively. Combination therapy showed a significantly higher (P < .01) disease-free survival than radiotherapy alone.

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Section: Discussionmentioning

confidence: 99%

Primary Subglottic Cancer

et al. 1998

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“…Variations also exist in the recommendations for managing late-stage disease. While some suggest RT alone [4,7], most series indicate that combined surgery and adjuvant RT is most effective [1,3,8,9,15]. Our series showed that late disease could be locally controlled well with surgery and adjuvant RT (80 %) as well as RT alone (71 %).…”

Section: Discussionmentioning

confidence: 59%

Radiation therapy for squamous cell carcinoma of the subglottic larynx

et al. 2012

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Objective This study aims to summarize our institution's experience in treating patients with primary subglottic squamous cell carcinoma (SCC) with radiotherapy (RT) and to define the optimal treatment plan for these patients. Methods We retrospectively reviewed the medical records of 18 patients with subglottic SCC curatively treated with RT between 1977 and 2009. T 1 and T 2 cancers were considered early disease; T 3 and T 4 lesions were considered advanced disease. Patients were stratified according to whether they received RT alone or RT and surgery. Patients treated surgically tended to have more advanced disease and required a total laryngectomy. Patients were excluded if they had distant metastasis at diagnosis or if their tumor was glottic in origin and extended inferiorly into the subglottis. Results Twelve patients (67 %) had advanced disease, and six patients (33 %) had early disease. Local control was achieved in 100 % of the patients with early disease, regardless of treatment group. Of the patients with advanced disease, local control was achieved in five of the seven patients (71 %) treated with RT alone and in four of the five (80 %) treated with surgery and RT. Ultimate local control was achieved in six of the seven patients (86 %) with advanced disease treated with RT alone. Overall local control was 83 % at 5 years, with a 5-year cause-specific survival of 66 % and a 5-year overall survival of 44 %. Local-regional control mirrored that of local control, with an overall local-regional control rate of 83 %. No patient suffered a severe acute or late complication or acute toxicity during the treatment process. Conclusion Patients with SCC of the subglottic larynx have a high likelihood of local-regional control after undergoing RT along or combined with surgery. Those with T 1-T 2 and low volume T 3-T 4 cancers have high probability of local control with voice preservation after definitive RT.

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“…Results of some studies regarding treatment of subglottic carcinoma with radiotherapy or chemoradiotherapy are listed in Table 2. 2,4,[13][14][15][16][17][18][19][20][21][22][24][25][26] Similarly, Paisley et al 17 treated 43 patients with subglottic carcinoma with radiotherapy alone. Twenty patients had T3 or T4 tumors, and local control was achieved in 24 of 43 patients (54%).…”

Section: Prognosis and Treatment Results Of Subglottic Carcinomamentioning

confidence: 99%

Prognosis of subglottic carcinoma: Is it really worse?

et al. 2018

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It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. There is also a rich lymphatic network in the subglottis draining to the prelaryngeal and paratracheal lymph nodes, which are usually not involved by cancers arising in other laryngeal subsites. Current literature data indicates that early-stage subglottic carcinoma can be treated using radiotherapy or chemoradiotherapy with high locoregional control and survival rates. In advanced stage subglottic carcinoma, combination of surgery followed by radiotherapy or chemoradiotherapy resulted in comparable outcomes, as in advanced carcinomas from the rest of the larynx. Stage for stage, it is likely that the prognosis for subglottic carcinoma and of glottic and supraglottic cancers is similar.

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Primary radiotherapy for subglottic carcinoma

Cited by 16 publications

References 11 publications

Primary Subglottic Cancer

Primary Subglottic Cancer

Radiation therapy for squamous cell carcinoma of the subglottic larynx

Prognosis of subglottic carcinoma: Is it really worse?

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