Prognosis of subglottic carcinoma: Is it really worse?

Abstract

It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. There is also a rich lymphatic network in the subglottis draining to the prelaryngeal and paratracheal lymph nodes, which are usually not involved by cancers arising in other laryngeal subsites. Current literature data indicates that early-stage subglottic carcinoma can be treated using radiotherapy or chemoradiotherapy with high locoregional control and survival rates. In advanced stage subglottic carcinoma, combination of surgery followed by radiotherapy or chemoradiotherapy resulted in comparable outcomes, as in advanced carcinomas from the rest of the larynx. Stage for stage, it is likely that the prognosis for subglottic carcinoma and of glottic and supraglottic cancers is similar.

Subglottic squamous cell carcinoma in Denmark 1971–2015 – a national population-based cohort study from DAHANCA, the Danish Head and Neck Cancer group

“…Other published studies on subglottic SCC presents small, retrospective single institution cohorts (N ¼ 10-89) [10,20] except from one study by Marchiano et al [2] including more than 889 cases extracted from the SEER database. In the study by Marchiano, the primary treatment was RT (34%), surgery (17%), combination of RT and surgery (39%), and no treatment (10%).…”

“…Since primary subglottic SCC is a rare disease, knowledge regarding the clinical course of the disease and treatment outcome is sparse [10]. Except from one American study based on the SEER database (Surveillance, Epidemiology, and End Results Program) [2], therapeutic studies on subglottic cancers are small including less than 60 patients [3][4][5]8,9,11,12] and based on single institution populations.…”

Subglottische Pathologien

“…Eine mögliche Lymphknotenmetastasierung betrifft üblicherweise paratracheale bzw. mediastinale und selten cervicale Lymphknoten aufgrund der guten Lymphgefäßversorgung der Subglottis mit submuköser Ausbreitung [59,60,65]. Eine kombinierte Therapie, bestehend aus Radiotherapie und Operation (38,8 %), gefolgt von alleiniger Radiotherapie (33,9 %) bzw.…”

Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress

“…The incidence of head and neck tumors is high in malignant carcinomas, and they are the sixth most common type of cancer around the world. About 25% of head and neck tumors are laryngeal carcinomas 1,2 . Hence, the incidence of laryngeal squamous cell carcinoma (LSCC) in the laryngeal tumors is high (98%) among patients, and its incidence has enormously increased despite the use of several environmental protection and drug treatment procedures on the patients 1,2 .…”

“…About 25% of head and neck tumors are laryngeal carcinomas 1,2 . Hence, the incidence of laryngeal squamous cell carcinoma (LSCC) in the laryngeal tumors is high (98%) among patients, and its incidence has enormously increased despite the use of several environmental protection and drug treatment procedures on the patients 1,2 . For the treatment of laryngeal tumors, chemotherapeutic agents represents an important impact, even though they also have several adverse effects in normal cells 3 .…”