Primary pure non-gestational choriocarcinoma of ovary: a rare case report

Rawal, Gireesha; Ahluwalia, Charanjeet; Yadav, Amit Kumar; Dhawan, Indrani

doi:10.18203/2320-1770.ijrcog20174086

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…16 A case report of a young women with a clinical suspicion of ruptured ectopic pregnancy underwent emergency laparotomy with an intra op finding of ovarian mass with bleeding later diagnosed as primary pure non-gestational choriocarcinoma of ovary. 17 The only case report of a 13-year-old girl with pure choriocarcinoma in turkey managed with triple chemotherapy consisting of metho-trexate, actinomycin and cyclophosphamide that was started 2 weeks following the surgery at an oncology center and was followed with β-hCG and the patient received one additional course of chemo-therapy. 18…”

Section: Discussionmentioning

confidence: 99%

A pure and bizarre ovarian malignancy - choriocarcinoma: case report

Kanchan

Guruvare

2022

Int J Reprod Contracept Obstet Gynecol

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Germ cell malignancies represent 15% of ovarian cancers in Asians. Choriocarcinoma is a malignant tumor of the ovary with trophoblastic differentiation can be gestational or non-gestational in origin the study is aimed to increase awareness of rare malignant cancer in children that can present in uncommon symptoms and is diagnosed only if the doctor is vigilant. It is a prospective observational case report. Though uncommon a cancer, choriocarcinoma cases have been reported several times in the literature with no definitive treatment plan. The neoadjuvant chemotherapy followed by surgery has proven too successful in the above case. A multidisciplinary approach to juvenile cancer can have a fruitful outcome with high cure rates. The rarity of this cancer makes it difficult to have clear cut diagnosis fixed treatment plan. A good history taking and easy availability of ultrasound with fast-track referral can save many lives from the deadly disease like cancer. Due to paucity of data in regard to pure choriocarcinoma this case report may help in gathering more attention to the research towards this cancer.

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Section: Discussionmentioning

confidence: 99%

A pure and bizarre ovarian malignancy - choriocarcinoma: case report

Kanchan

Guruvare

2022

Int J Reprod Contracept Obstet Gynecol

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“…At beta-HCG levels seen in NGOC cases, the Hook Effect becomes relevant [32]. When using point of care urine pregnancy tests, the Hook Effect occurs in sandwich immunoassays when the antigen concentration is high enough to saturate both the migratory phase and fixed detection antibodies independently, rather than binding occurring to subunits of the same molecule [14,15]. Thus, a falsely negative test could potentially lead to a delay in diagnosis and allow for progression of disease [33].…”

Section: Laboratorymentioning

confidence: 99%

“…There are two types of NGOC: the pure type and the mixed type. The pure type, which is extremely rare, only contains choriocarcinoma [14]; the absence of other germ cell elements is demonstrated by the lack of immunohistochemical staining for CD30, PLAP, and AFP [15]. The mixed type contains other germ cell tumors, including immature teratomas, endodermal sinus tumors, embryonal carcinomas, and dysgerminomas [13].…”

Section: Introductionmentioning

confidence: 99%

Non-Gestational Ovarian Choriocarcinoma: A Rare Ovarian Cancer Subtype

et al. 2022

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Non-Gestational Ovarian Choriocarcinoma (NGOC) is an extremely rare ovarian tumor, with an incidence of less than 0.6% of malignant ovarian germ cell tumors. Its close pathologic resemblance to Gestational Ovarian Choriocarcinoma (GOC), however, requires special attention as the treatments differ greatly. NGOC typically affects patients in late adolescence or early reproductive years. As a result, NGOCs are often misdiagnosed as ectopic pregnancies due to their common presentation of bleeding, abdominal pain, adnexal mass, and positive serum beta-HCG. On pathologic examination, the tumor is indistinguishable from GOC, and only after review of tissue for paternal genetic components can the diagnosis of NGOC be made. Imaging studies often show highly vascular lesions with further investigation with computer topography (CT) sometimes showing metastatic lesions in the lungs, pelvis, vagina, and liver. These lesions are often hemorrhagic and can lead to catastrophic bleeding. Treatment is vastly different from GOC; NGOC requires treatment with both surgical resection and chemotherapy, with Bleomycin, Etoposide, and Cisplatin (BEP) being the most used regimen. With correct diagnosis and treatment, patients can often receive fertility sparing treatment with long term survival.

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“… 4 Generally, NGCO have been clinically diagnosed in female patients who were sexually immature, unable to conceive, or have never had sexual intercourse. 5 Ovarian germ cell tumours commonly occur in the first two decades of life, but can also be seen in any age group. 6…”

Section: Introductionmentioning

confidence: 99%

Non-gestational choriocarcinoma of the ovary: A case report

Yee

Zakaria

Mohamad

et al. 2021

Journal of Taibah University Medical Sciences

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Non-gestational choriocarcinoma of the ovary is an extremely rare clinical condition. Very few cases of this high-grade malignancy of the ovary are reported in the literature worldwide. Given the rarity of the tumour, this disease is generally overlooked, which leads to delayed diagnosis and management. For the attending clinicians, the non-gestational choriocarcinoma of the ovary poses a diagnostic challenge due to its non-specific clinical presentations. A 16-year-old girl presented with pain in the right iliac fossa and with a positive urine pregnancy test. Despite being sexually inactive, the patient was diagnosed with an ectopic pregnancy and underwent emergency laparoscopic surgery. Six weeks later, the histopathological analysis revealed a diagnosis of non-gestational choriocarcinoma of the ovary. Further evaluations showed that her cancer had already advanced to stage IV. In this case report, the non-specific presentations of the disease, radiological features, current treatments, and possible safety strategies are discussed.

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Primary pure non-gestational choriocarcinoma of ovary: a rare case report

Cited by 3 publications

References 7 publications

A pure and bizarre ovarian malignancy - choriocarcinoma: case report

A pure and bizarre ovarian malignancy - choriocarcinoma: case report

Non-Gestational Ovarian Choriocarcinoma: A Rare Ovarian Cancer Subtype

Non-gestational choriocarcinoma of the ovary: A case report

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