Primary Prevention of HTLV-I in Japan

Hino, Shinjiro; Katamine, Shigeru; Miyata, Hironori; Tsuji, Yoshiro; Yamabe, Toru; Miyamoto, Tsutomu

doi:10.1097/00042560-199600001-00030

Cited by 106 publications

(124 citation statements)

References 20 publications

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“…Mother-to-child transmission, mainly due to ingestion of breast milk during breastfeeding, has been reported to be the predominant route (Tsuji et al, 1990). The rates of HTLV-I transmission from mother to child are 2?7 % in formula-fed infants, 5 % after 3 months of breastfeeding and up to 39 % with prolonged breastfeeding (Tsuji et al, 1990;Hino et al, 1996;Takezaki et al, 1997;Wiktor et al, 1997). Antenatal screening for HTLV-I and the recommendation for formula feeding of infants of HTLVseropositive mothers have been carried out in the Nagasaki prefecture of Japan since 1987 (Hirata et al, 1992;Wiktor et al, 1997) and have been proposed in Europe (Nightingale et al, 1993;Weber & Taylor, 1996;Hale et al, 1997;Otigbah et al, 1997;Taylor et al, 2005) and Jamaica (Hanchard, 1996).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of human T-cell lymphotropic virus type I among pregnant women in Accra, Ghana

Armah

Narter-Olaga

Adjei

et al. 2006

Journal of Medical Microbiology

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Infection with human T-cell lymphotropic virus type I (HTLV-I) occurs mainly in Japan, Central and West Africa and the Caribbean Basin. Although antibody to HTLV-I has been reported among pregnant women in several endemic countries, there is no information regarding the seroprevalence in pregnant Ghanaian women. The reported seroprevalence of HTLV-I among healthy Ghanaian blood donors is between 0?5 and 4?2 %. Therefore, this study was conducted to determine the seroprevalence of HTLV-I among pregnant women attending the antenatal clinic at the 37 Military Hospital, Accra, Ghana, between the months of January and December 2003. The presence of antibodies specific for HTLV-I/II was tested using a particle agglutination test (PAT) kit and confirmed by Western blotting (WB). Of the 960 sera tested, HTLV-I/II antibodies were detected in 24 samples using the PAT kit. WB results indicated that, of the 24 positive PAT specimens, 20 specimens (83?3 %) were HTLV-I positive, one (4?2 %) was HTLV-II positive, two (8?3 %) were HTLV positive and one (4?2 %) was indeterminate. Therefore, the overall seroprevalence of HTLV-I was 2?1 %. Seroprevalence increased with age, suggesting sexual contact as the primary mode of transmission among women of childbearing age, rather than breastfeeding during infancy. The seroprevalence of 2?1 % reported here for HTLV-I in pregnant women in Accra is comparable to that of human immunodeficiency virus among the same population. In conclusion, the results indicate that HTLV-I is prevalent among asymptomatic Ghanaian pregnant women and thus there is a need to consider introducing antenatal screening for HTLV-I in Ghana. INTRODUCTIONHuman T-cell lymphotropic virus type I (HTLV-I) is known to be the pathogenic agent of adult T-cell leukaemia/lymphoma (ATLL) (Poiesz et al., 1980;Yoshida et al., 1982) and HTLV-I-associated myelopathy/tropical spastic paraparesis (Gessain et al., 1985; Osame et al., 1987). ATLL develops after a long incubation period, with an estimated lifetime risk of approximately 3-8 % in individuals infected before the age of 20 years (Cleghorn et al., 1995). As the prognosis for patients with ATLL is extremely poor, with median survival after diagnosis of <6 months (Takatsuki et al., 1996), the prevention of mother-to-child transmission of HTLV-I is of the utmost importance. HTLV-I is not ubiquitous, but is endemic in some geographical areas and among some ethnic groups. Population-based studies have reported the prevalence of antibody to HTLV-I to range from 3-6 % in Jamaica, Trinidad and the Caribbean islands to 23?2 % in Nagasaki Prefecture in south-western Japan (Blattner et al., 1990;Murphy et al., 1991; Kishihara et al., 2001). High HTLV-I seroprevalence rates (>2 % in the adult population) have been described in southern Japan, sub-Saharan Africa, the Caribbean Basin, parts of South America and some areas of Melanesia and the Middle East, where 15-20 million people are infected with this virus (Kazanji & Gessain, 2003). In every endemic population, there is an increase i...

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Section: Introductionmentioning

confidence: 99%

Seroprevalence of human T-cell lymphotropic virus type I among pregnant women in Accra, Ghana

Armah

Narter-Olaga

Adjei

et al. 2006

Journal of Medical Microbiology

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“…[1][2][3][4] The major route of HTLV-1 infection is mother-to-child transmission via breast milk, and both bottlefeeding and short-term breast-feeding reduce the risk of neonatal infection with HTLV-1. 5,6) However, once HTLV-1 infects T lymphocytes and integrates its provirus into the host genome, the virus cannot be excluded from the body. A high level of HTLV-1 provirus load in circulating lymphocytes of HTLV-1 carriers is a risk factor for HTLV-1-related diseases.…”

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confidence: 99%

HTLV‐1 provirus load in peripheral blood lymphocytes of HTLV‐1 carriers is diminished by green tea drinking

et al. 2004

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“…In endemic areas, approximately 25% of breastfed children born to HTLV-1 seropositive mothers may acquire this virus [9,10]. At one time, Japan had high rates of MTCT, ranging from 15 to 25% [11]. However, through the systematic serological screening of pregnant women and by avoiding breastfeeding, the MTCT rate recently decreased to approximately 3% [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Reproductive Decisions among People Living with Human T-cell Lymphotropic Virus Type 1 (HTLV-1)

Alvarenga¹

2013

J Infect Dis Ther

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Background: Human T-cell Lymphotropic Virus type 1 (HTLV-1) infection is a neglected public health problem. The majority of carriers is asymptomatic and may have a low risk of developing related diseases. The aims of this study were to discuss reproductive decisions of women and men living with HTLV-1 infection to assess their perception of infection and associated diseases, expectations regarding Mother-to-Child Transmission (MTCT), and whether health care conditions may affect their reproductive decisions.

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Primary Prevention of HTLV-I in Japan

Cited by 106 publications

References 20 publications

Seroprevalence of human T-cell lymphotropic virus type I among pregnant women in Accra, Ghana

Seroprevalence of human T-cell lymphotropic virus type I among pregnant women in Accra, Ghana

HTLV‐1 provirus load in peripheral blood lymphocytes of HTLV‐1 carriers is diminished by green tea drinking

Reproductive Decisions among People Living with Human T-cell Lymphotropic Virus Type 1 (HTLV-1)

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