Primary pleomorphic liposarcoma of the thoracic epidural space: case report

Primary Myxoid Liposarcoma of the Upper Thoracic Spine in an Elderly Patient

“…The final diagnosis is based on the histopathological findings according to the criteria established by the WHO, and immunohistochemical analysis always needs to be performed to establish a certain diagnosis. [1,5,8] Our case report represents a true primary myxoid liposarcoma aroused within a thoracic vertebra with a proven negative metastatic workup in a 79-year-old patient, based on the histological features consistent with this diagnosis. A search of the literature revealed only seven cases of primary myxoid and five cases of primary pleomorphic liposarcoma of the spine.…”

“…[2,4,5,7] Pleomorphic liposarcoma, the rarest form of liposarcoma, accounting for 5% of all liposarcomas, is an aggressive tumor and appears more often in the sixth and seventh decades of life. [8][9][10] Myxoid liposarcoma is the second most common histological type, accounting for 30%-40% of cases, and occurring more frequently in younger patients between 40 and 60 years of age. [2] The most frequent sites of myxoid liposarcomas are buttocks, retroperitoneum, trunk, and proximal limb girdle, but primary spinal involvement is a rare entity.…”

“…Gender Site Type of tumor Hamlat et al [1] 45 Female Thoracic Pleomorphic Lmejjati et al [5] 45 Male Lumbar Pleomorphic Halevi et al [8] 70 Male Thoracic Pleomorphic de Moraes et al [4] 60 Female Lumbar Pleomorphic Morales-Codina et al [9] 60 Male Lumbar Pleomorphic Cho et al [2] 41 Female Cervical Myxoid Borghei Razavi et al [6] 56 Female Cervical Myxoid Kaneuchi et al [10] 22 Female Thoracic Myxoid Turanli et al [7] 65 Female Lumbar Myxoid Zhao et al [3] 44 Male Lumbar Myxoid Zhao et al [3] 37 Male Lumbar Myxoid Zhao et al [3] 32 Male Cervical Myxoid Present case 79 Male Thoracic Myxoid…”

Pleomorphic Liposarcoma Unraveled: Investigating Histopathological and Immunohistochemical Markers for Tailored Diagnosis and Therapeutic Innovations

“…For instance, Agarwal et al investigated the characteristics of pleomorphic liposarcoma of the head and neck and noted the importance of adjuvant therapy and negative resection margins in avoiding recurrent disease in a one-year follow-up [ 53 ]. Halevi PD et al reported an unfavorable outcome in the case of a primary pleomorphic liposarcoma arising within the thoracic epidural space in a 70-year-old male patient who presented with lower extremities weakness and back pain [ 54 ]. The patient underwent surgical excision and received radiotherapy, but the lesion recurred 3 months after the surgery [ 54 ].…”

“…Halevi PD et al reported an unfavorable outcome in the case of a primary pleomorphic liposarcoma arising within the thoracic epidural space in a 70-year-old male patient who presented with lower extremities weakness and back pain [ 54 ]. The patient underwent surgical excision and received radiotherapy, but the lesion recurred 3 months after the surgery [ 54 ]. Later on, he developed metastases and succumbed to the disease one year later [ 54 ].…”