Primary Peritoneal Carcinoma Presenting on Routine Papanicolaou Smear

Olsen, Tandy G.; Nycum, Lawrence R.; Graham, Rick; Alagoz, Turgut

doi:10.1006/gyno.2000.5812

Cited by 10 publications

(11 citation statements)

References 10 publications

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“…However, sometimes, an abnormal Pap smear can be the first manifestation of extrauterine malignancy, with the most common primary sites being the ovaries, followed by the gastrointestinal tract, fallopian tubes and breasts [4,5,8,9,15]. …”

Section: Discussionmentioning

confidence: 99%

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Ovarian Serous Borderline Tumor Detected by Conventional Papanicolaou Smear: A Case Report

Tepeoğlu

Özen²,

Ayhan³

2012

Acta Cytologica

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Background: Although the Papanicolaou (Pap) smear was originally designed to detect premalignant cervical lesions and cancer, it has become apparent that malignant cells from extrauterine primaries may also appear in the smears. Here, we report a case of a serous borderline tumor (SBT) of the ovary that was detected by a conventional Pap smear. Case Report: In a 34-year-old woman, who was operated on for a left borderline ovarian tumor 2 years ago, glandular dysplasia was discovered in a Pap smear screening. The Pap smear showed a large number of atypical glandular cells forming 3-dimensional papillary clusters. The cell clusters were enlarged and had variably sized round or oval nuclei. The background was clean, and this finding pointed to the noncervical origin of the malignant cells. A right ovarian cystic mass was discovered and a laparotomy performed. A histologic examination of the ovarian mass revealed a SBT of the ovary. Conclusion: This case illustrates the value of the Pap smear in discovering unsuspected extrauterine malignancies, including SBTs of the ovary.

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Section: Discussionmentioning

confidence: 99%

“…The Papanicolaou (Pap) smear is accepted worldwide as an important screening test for the detection and prevention of cervical cancer [4,5,6]. In rare cases, atypical or malignant cells found in a cervical smear can be an indication of the existence of an extrauterine malignancy [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Serous Borderline Tumor Detected by Conventional Papanicolaou Smear: A Case Report

Tepeoğlu

Özen²,

Ayhan³

2012

Acta Cytologica

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“…In our case, a primary peritoneal adenocarcinoma was found in a woman feeling totally healthy. To our knowledge, only four other cases of primary peritoneal adenocarcinoma diagnosed via an abnormal cervical smear have been reported 2–5.…”

Section: Discussionmentioning

confidence: 95%

Asymptomatic primary peritoneal carcinoma presenting as adenocarcinoma on routine cervical cytology

Christensen

Gernow

Rasmussen

2006

Acta Obstet Gynecol Scand

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“…Case reports of both primary peritoneal carcinoma [5] and ovarian adenocarcinomas [6] presenting as glandular abnormalities on routine Papanicolaou smear have appeared in the recent gynecologic literature. The fact that this occurrence is a rare event even in women with ovarian or ovarian‐type epithelial malignancies prior to surgery further underscores the anticipated low yield this test might have in patients following surgical resection when the cervix and uterus is surgically absent and the vaginal vault closed.…”

Section: Discussionmentioning

confidence: 99%

Papanicolaou Smears Are of Little Value in the Post-Treatment Surveillance of Patients with Ovarian Epithelial Cancer

Patsner¹

2001

J Low Genital Tract Dis

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275 consecutive patients with ovarian epithelial cancer had routine brush vaginal vault cytology performed as part of routine post-treatment surveillance for recurrent disease screening. No patient with stage I or II disease (75 patients total) developed either recurrent vaginal vault disease or had an abnormal Pap smear indicating recurrent adenocarcinoma or even atypical glandular cells of undetermined significance (AGCUS). Of the 200 patients with stage III or IV disease there were four vaginal vault recurrences (three macroscopic, one microscopic); all of these recurrences had recurrent disease elsewhere and none were detected on the basis of Papanicolaou smear alone. Papanicolaou smear may be safely omitted as part of any post-treatment surveillance protocol for patients with ovarian epithelial cancers.

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Primary Peritoneal Carcinoma Presenting on Routine Papanicolaou Smear

Cited by 10 publications

References 10 publications

Ovarian Serous Borderline Tumor Detected by Conventional Papanicolaou Smear: A Case Report

Ovarian Serous Borderline Tumor Detected by Conventional Papanicolaou Smear: A Case Report

Asymptomatic primary peritoneal carcinoma presenting as adenocarcinoma on routine cervical cytology

Papanicolaou Smears Are of Little Value in the Post-Treatment Surveillance of Patients with Ovarian Epithelial Cancer

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