Ovarian Serous Borderline Tumor Detected by Conventional Papanicolaou Smear: A Case Report

Tepeoğlu, Merıh; Özen, Özlem; Ayhan, Ali̇

doi:10.1159/000339007

Cited by 11 publications

(12 citation statements)

References 20 publications

(15 reference statements)

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“…The present case describes rare case of a borderline serous tumor detected by Pap smear. To our knowledge there are only six described cases in literature of SBT detected by Pap smear as the first presentation of the disease (8,14,16,17,18,19) and one case of an ovarian seromucinous borderline tumor recurrence (20). Psammoma bodies were found in five of described SBT cases (8,14,16,18,19), two of them with psammoma bodies only (8,14) and others with abnormal glandular cells like in our case.…”

Section: Discussionsupporting

confidence: 46%

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

et al. 2021

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The Pap test is designed as a screening test to detect primarily carcinoma of the cervix and its precursors, most often of squamous type. Rarely atypical or malignant cells found in cervical smear can be indication for the existence of an extrauterine disease. We present a case of a 26 year old woman with very small asymptomatic ovarian bilateral borderline tumors whose diagnosis was triggered by finding of atypical glandular cells with psammoma bodies on Pap smear. She had a history of abnormal Pap smears and was admitted to our Hospital for colposcopy. Pap smear was taken and reported as atypical glandular cells (AGC) with psammoma bodies. Colposcopically directed biopsy along with an endocervical curettage showed no abnormalities as well as transvaginal ultrasound examination. Three months later control Pap smear confirmed AGC with psammoma bodies (suggestive of endometrial or serous origin), ultrasound showed the presence of indistinctive, hyperechoic mass 2 cm in diameter in the left ovary along with slightly elevated CA-125 and diagnostic hysteroscopy and laparoscopy was performed. At laparascopy, both ovaries had surface cauliflower like papillary projections measuring up to 3 cm. A histological examination revealed bilateral serous borderline tumor.

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Section: Discussionsupporting

confidence: 46%

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

et al. 2021

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“…Nwanodi et al stated in a review that 10% to 40% of ovarian cancer demonstrated malignant cells on cervicovaginal cytology [ 5 ]; nine out of 11 were at grade III or a more advanced stage. Tepeoğlu et al reviewed six cases of ovarian serous borderline tumors presented as atypical glandular cells and psammoma bodies in a Pap smear [ 6 ], and none were diagnosed at a FIGO stage less than IIB. We summarize similar cases from the literature in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

Early-Stage, BRCA-Associated Ovarian Cancer Detected by Papanicolaou Smear: A Case Report

Su¹,

Su²,

Liu³

et al. 2023

Cureus

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Historically known as a "silent killer", ovarian cancer is often diagnosed at an advanced stage. We describe an unusual case of stage I, ovarian, high-grade serous carcinoma detected by a routine Papanicolaou (PAP) smear, with no abnormal physical, imaging, or laboratory findings. A 53-year-old woman with newly diagnosed triple-negative breast cancer received a screening Pap smear, which showed malignant cells not coming from the breast or uterine cervix. Pelvic examination, cervical biopsy, and gynecologic ultrasonography found no abnormality. Endometrial curettage yielded free-floating adenocarcinoma cells. The immunohistochemical stain result indicated ovary or fallopian tube cancer. Complete cytoreductive surgery was performed, and high-grade serous carcinoma of bilateral ovaries, FIGO stage IB, was diagnosed. Although extremely rare, when malignant cells not originating from the uterine cervix are detected on a Pap smear, it may lead to an early diagnosis of ovarian cancers, and this warrants further comprehensive workup.

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“…The conventional Papanicolaou smear probably deserves to be developed not only for early detection of ovarian serous borderline tumours [108] but also for invasive cancers; 41% (9/22) of ovarian cancers were identified using a panel of mutated genes from liquid Papanicolaou smear specimens [109]. …”

Section: Discussionmentioning

confidence: 99%

Early Preinvasive Lesions in Ovarian Cancer

Chêne

Lamblin

Bail-Carval

et al. 2014

BioMed Research International

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Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development of new screening strategies. We discuss here the early natural history of ovarian cancer and its origins.

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Ovarian Serous Borderline Tumor Detected by Conventional Papanicolaou Smear: A Case Report

Cited by 11 publications

References 20 publications

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

Early-Stage, BRCA-Associated Ovarian Cancer Detected by Papanicolaou Smear: A Case Report

Early Preinvasive Lesions in Ovarian Cancer

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