Primary peritoneal and ovarian cancers: an epidemiological comparative analysis

Abstract

We performed case–control analyses using data from the North Carolina Ovarian Cancer Study to determine risk factors that distinguish primary peritoneal cancer (PPC) from epithelial ovarian cancer (EOC). Our risk factor analyses were restricted to invasive serous cancers including 495 EOC cases, 62 PPC cases and 1,086 control women. Logistic regression analyses were used to calculate adjusted odds ratios and 95% confidence intervals for risk factor associations. Although many case–control associations for the invasive serous PPC cases were similar to those of the invasive serous EOC cases, some differences were observed including a twofold increase in risk of invasive serous PPC in women who were ≥35 years at last pregnancy, whereas a decreased risk was observed for invasive serous EOC risk. We could not confirm a previous report of an association between tubal ligation and PPC, a factor consistently associated with a decreased risk of EOC. The difference in the risk factor associations between invasive serous PPC and EOC cancers suggests divergent molecular development of peritoneal and ovarian cancers. A larger study to determine risk factors for invasive serous PPC is warranted.

Demographic clinical and prognostic characteristics of primary ovarian, peritoneal and tubal adenocarcinomas of serous histology — A prospective comparative study

“…Our study although insignificant supports these results. A recent smaller study did not find an association between obesity and PPC or POC vs. controls [8]. No association between BMI and PFC as compared to POC has been reported previously.…”

“…The association between obesity and PPC as compared to a control group or POC was addressed in three former studies [8][9][10]. Two studies observed an association between a high BMI and PPC as compared to POC or a normal control group.…”

Tubal Ligation and Incidence of 26 Site-Specific Cancers in the Million Women Study

“…Few other studies have reported on the association between tubal ligation and risk of peritoneal cancer, and they have tended to be limited by small numbers of cases. Our study included 730 cases of peritoneal cancer; two retrospective studies have reported their findings-one study including 62 cases found no association (Grant et al, 2010); and another including 22 cases reported a reduced risk (Purdie et al, 1995;Green et al, 1997).…”

Extraovarian primary peritoneal carcinoma: staging with 18F-FDG PET/CT

“…The incidence of EOPPC is much lower than that of EOC (6.78 cases per million vs. 120.5 cases per million), but its incidence has been increasing over the last 30 years. Features shared by EOC and EOPPC include preponderance of serous histology, advanced stage at diagnosis for majority of women, and similar responsiveness to platinum/taxane chemotherapy, leading some investigators to suggest a common cell lineage from the embryonic Mullerian system [6,7]. However, recent molecular and epidemiologic findings indicate that EO-PPC may be an entirely distinct entity [5,8].…”