Primary Peripheral B Cell Lymphoma, Burkitt-Like, of the Cranial Vault

Tanimura, Akiko; Adachi, Yasushi; Tanda, M.; Yuasa, H; Ishii, Yoshifumi; Katou, Yasuo

doi:10.1159/000084680

Cited by 19 publications

(12 citation statements)

References 37 publications

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“…However, almost any lymphoma histology has been reported causing primary bone disease, including low grade histologies, anaplastic lymphoma [11] and Burkitt lymphoma [12]. Interestingly, the sites of occurrence differ among the various studies: in two series of Japanese patients, PBL most commonly involved the pelvis, [13,14] in others the most common sites of disease were the long bones, [15,16] another study of 131 patients of the British Columbia Cancer Agency reported equal frequency between axial and extremity involvement [17] and finally the SEER database study reported a predominance of axial involvement among 1,500 PBL patients [7], a finding our study shares.…”

Section: Discussionmentioning

confidence: 99%

Primary Bone Lymphoma: A Retrospective Analysis of 22 Patients Treated in a Single Tertiary Center

Matikas

Briasoulis²,

Tzannou³

et al. 2013

Acta Haematol

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Background: Primary bone lymphoma is a rare disease, representing less than 5% of all extra-nodal non-Hodgkin lymphomas. Materials and Methods: We retrospectively searched the database of the lymphoma unit, Hematology/Lymphoma Department, Athens General Hospital ‘Evangelismos' for primary bone lymphoma patients. Demographic and clinicopathologic data were collected and overall survival was analyzed. A log-rank test was used in a univariate analysis to identify factors affecting overall survival. Results: We identified 24 and analyzed data from 22 patients. 12 were male (54.5%) and 10 female (45.4%) and their median age was 55 years (range: 19-83). Most patients had localized disease at the time of diagnosis (n = 19, 86.3%), the most common site was the spine (n = 11, 50%) and the most common histology was diffuse large B-cell lymphoma. 21 patients received chemotherapy as initial therapy and 16 received combined chemoradiation. 81.8% of the patients (n = 18) achieved complete remission. 5-year survival rate was 86.3% and overall survival was found to be affected by the patients' initial response to treatment. Conclusions: Primary bone lymphoma is usually associated with a good prognosis. Prospective studies are needed in order to clarify the effect of immunochemotherapy in overall survival.

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Section: Discussionmentioning

confidence: 99%

Primary Bone Lymphoma: A Retrospective Analysis of 22 Patients Treated in a Single Tertiary Center

Matikas

Briasoulis²,

Tzannou³

et al. 2013

Acta Haematol

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“…This patient had all of these diagnostic criteria. Causes of PLB have been suggested to be inflammation, trauma, or viral infections, but our patient had none of these [3]. …”

Section: Discussionmentioning

confidence: 84%

“…Primary lymphoma of the bone (PLB) is uncommon, accounting for only 7% of all malignant bone tumors and less than 1% of all non-Hodgkin's lymphomas, and the majority of them involve the pelvis or limb bones [1-3]. Primary cranial vault involvement is rarely reported [4].…”

Section: Introductionmentioning

confidence: 99%

Primary Malignant Lymphoma of the Cranial Vault with Extra- and Intracranial Extension

Hwang

Park

et al. 2013

Brain Tumor Res Treat

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Bone involvement is a common finding in many types of lymphomas, particularly in advanced stages. However, cranial vault affliction has been regarded as an exceedingly rare presentation. Here, we report the case of a patient with cranial vault lymphoma who presented with a scalp mass. An 81-year-old woman presented with a gradually growing and non-painful frontal scalp mass that she noticed one month before admission. It was a flatly elevated, round mass measuring about 6×4×4 cm. Computed tomography and magnetic resonance imaging of the brain revealed a contrast-enhancing intracranial extradural mass at the counter-location of the scalp mass. The superior sagittal sinus was involved at the tumor site. Cerebral angiography showed that the tumor feeding vessels originated from the bilateral external carotid arteries. An operation was performed and the tumors were removed together with the involved bone. The pathologic diagnosis was malignant diffuse large B-cell type lymphoma. The patient was transferred to the Hemato-Oncology department for chemotherapy. Primary lymphoma of the cranial vault with scalp mass is very rare but it should be considered in the differential diagnosis of scalp masses. Although the results of reported cases are variable, the combination of surgery, radiation, and chemotherapy appears to offer favorable outcomes.

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“…Our patient was diagnosed at the age of 26, much younger than the median age of this population which was 48 years in 19 similar cases of primary bone lymphoma of the skull which we reviewed [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation was the most commonly seen with skull lymphoma, where most cases reviewed also presented with a scalp lump or swelling [6][7][8][9][10][11][12][13], [15,21,22].…”

Section: Discussionmentioning

confidence: 99%

Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

Nader¹,

Saad²,

Najjar³

et al. 2017

J Leuk

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Primary Bone Lymphoma of the skull is extremely rare and has a variable clinical course and prognosis. We are describing a case of a 26 year old woman who presented with a 2 year history of intermittent scalp swelling and skull pain. Brain MRI showed thickening of the bilateral frontal bones and band thickening of the underlying meninges suggestive of band meningiomatosis. Patient was presumably diagnosed with a meningioma based on radiological findings and underwent resection; however, pathology was consistent with a B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. A PET CT scan showed sacral bone hypermetabolic lesion which was biopsied and consistent with same lymphoma features. She received chemotherapy with Rituximab and Hyper-CVAD protocol (Table 1) and had a sustained ongoing complete remission 19 months after her initial diagnosis. Several cases of primary lymphoma of the skull or cranial vault have been described in the literature, but only one other case with the same pathology of Burkitt-like lymphoma was found.

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Primary Peripheral B Cell Lymphoma, Burkitt-Like, of the Cranial Vault

Cited by 19 publications

References 37 publications

Primary Bone Lymphoma: A Retrospective Analysis of 22 Patients Treated in a Single Tertiary Center

Primary Bone Lymphoma: A Retrospective Analysis of 22 Patients Treated in a Single Tertiary Center

Primary Malignant Lymphoma of the Cranial Vault with Extra- and Intracranial Extension

Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

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