Primary Bone Lymphoma: A Retrospective Analysis of 22 Patients Treated in a Single Tertiary Center

Abstract

Background: Primary bone lymphoma is a rare disease, representing less than 5% of all extra-nodal non-Hodgkin lymphomas. Materials and Methods: We retrospectively searched the database of the lymphoma unit, Hematology/Lymphoma Department, Athens General Hospital ‘Evangelismos' for primary bone lymphoma patients. Demographic and clinicopathologic data were collected and overall survival was analyzed. A log-rank test was used in a univariate analysis to identify factors affecting overall survival. Results: We identified 24 and analyzed data from 22 patients. 12 were male (54.5%) and 10 female (45.4%) and their median age was 55 years (range: 19-83). Most patients had localized disease at the time of diagnosis (n = 19, 86.3%), the most common site was the spine (n = 11, 50%) and the most common histology was diffuse large B-cell lymphoma. 21 patients received chemotherapy as initial therapy and 16 received combined chemoradiation. 81.8% of the patients (n = 18) achieved complete remission. 5-year survival rate was 86.3% and overall survival was found to be affected by the patients' initial response to treatment. Conclusions: Primary bone lymphoma is usually associated with a good prognosis. Prospective studies are needed in order to clarify the effect of immunochemotherapy in overall survival.

Primary Bone Lymphoma: A Clinical Analysis of 17 Patients in a Single Institution

“…The extremities and spine were frequently involved sites in Caucasians [11][12][13] , while the pelvis and spine were frequently involved sites in our study and other studies performed in Japan [14,15] . In our study, the median age at diagnosis of PBL was 60 years, i.e.…”

“…In contrast, the proportions of DLBCL were 65% in our study and 68% in another Japanese report [14] . The majority of DLBCL in Caucasian patients with PBL are of GCB type [13] , while the proportion of GCB type is 66% in our study. The proportion of T/NK-cell type was around 12% in our report and in another Japanese report [14] , while it was only 5% in a Western report [6] .…”

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

“…The prognosis of PBL is relatively good and equal to that of same-stage systemic DLBCL (55). The five-year OS rates vary greatly, as demonstrated in clinical trials and retrospective population-based studies (2,9,20,28,29,51,53).…”

Clinical characteristics of primary extranodal versus nodal diffuse large B-Cell Lymphoma: A retrospective cohort study in a cancer center

“…The most common initial symptoms described are local pain followed by nerve compression and local mass 8 , as in our study: about 80% of patients had pain, 40% referred paraparesis, and 20% had a bone fracture. A study from Japan 27 reported that the pelvis was the primary site involved (54%) rather than the extremities; however, Matikas et al 28 and Hayase et al 21 described the spine as the most frequent primary involved site. In our study, 40% of patients had an axial localization, 40% were appendicular, and 20% had multifocal (axial and appendicular) bone involvement.…”