Primary Papillary Carcinoma in Thyroglossal Cysts. Case Reports and Literature Review

Chala, Andrés; Álvarez, Andrés; Sanábria, Álvaro; Gaitán, Alejandro Pérez

doi:10.1016/j.otoeng.2016.03.005

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…7 Papillary thyroid carcinoma (PTC) is the most common malignancy found in a TDC (80.0%), followed by follicular or mixed papillary follicular carcinoma (9.0%), squamous cell carcinoma (5.0%), adenocarcinoma (2.0%) and anaplastic carcinoma (1.0%). 8,9 PTC can present clinically as a solitary cystic neck mass without any thyroid lesion. In our case, there was no palpable lesion in the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

“…12 Thus, initial evaluation of an adult patient who presents with a cystic neck mass should include a detailed clinical history, a thorough head and neck examination, as well as FNAC of the mass and imaging. 9,10 Computed tomography scan, neck nu clear magnetic resonance imaging and ultrasound may show a solid heterogenous mass and may play an im portant role in pre-operative diagnosis, staging of malignancy and in the planning of treatment. 14 The surgical excision of a thyroglossal duct remnant is a Sistrunk's procedure, with removal of the thyroglossal duct cyst, part of the hyoid bone and the remaining atretic part of the duct.…”

Section: Discussionmentioning

confidence: 99%

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Papillary carcinoma of the thyroid in a thyroglossal cyst-a rare incidental finding

Akhtar¹,

Hasan²,

Warsi³

et al. 2020

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Papillary thyroid carcinoma (PTC) arising from a thyroglossal duct cyst is very rare. PTC usually presents as a slow-growing, painless thyroid mass or a solitary nodule in the neck. We intend to report a rare case of 47 year old male, who presented with a progressively increasing midline neck swelling for the last 4 years. On examination, the mass was cystic without any solid nodule. No palpable neck nodes ware present. A clinical diagnosis of thyroglossal duct cyst was made. Ultrasonography showed a single large lobulated cystic mass, with foci of calcification. Sistrunk procedure was followed to excise the lesion. Histopathological examination of the excised mass showed variable sized thyroid follicles, areas of calcification and foci of atypical cells with features of papillary thyroid carcinoma. The patient was treated with 50 Gy of Co-60 radiotherapy and 6 cycles of adjuvant chemotherapy with Cisplatin 50mg/m 2. He is doing well after 12 months of follow up period without any metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Papillary carcinoma of the thyroid in a thyroglossal cyst-a rare incidental finding

Akhtar¹,

Hasan²,

Warsi³

et al. 2020

MOJS

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“…12 Thyroid carcinoma occurring in a thyroglossal cyst is a rare entity with only few cases reported in the literature, with papillary carcinoma thyroid being the most common type, 13 followed by mixed papillary-follicular type and less than 5% being squamous cell type. 14,15 The predominant theories described for the development of this malignancy are not clear, but it could either be a metastatic spread from occult primary or spontaneous development from ectopic thyroid tissue present within thyroglossal cyst. 16 Malignancy occurs only in 1% of thyroglossal duct cysts and occurs most commonly in women, 17 with the mean age being during the fourth decade of life.…”

Section: Pathological Discussionmentioning

confidence: 99%

“…21 Metastatic spread is uncommon, and the prognosis is usually good. 15,26 Regional lymph node metastasis of thyroglossal duct carcinoma occurs only in 7% cases and local spread is usually rare. 9 Careful long term follow-up of papillary carcinoma of thyroglossal duct carcinoma is very important as it is a low grade malignancy and recurrences can be treated adequately with adequate follow-up.…”

Section: Pathological Discussionmentioning

confidence: 99%

Papillary Carcinoma Thyroid in Thyroglossal Cyst- A Case Report

Rao¹,

Rao²,

Kumar³

et al. 2019

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“…Ultrasound examination was most common, with lesions having a nonspecific cystic appearance. Computed tomography (CT) findings reported to be of value in identifying malignancy within a TGDC, include the presence of a solid component, mural nodule, or calcifications [3,19,42,43,50,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72]. However, these particular imaging findings were only of assistance in a few cases [4,38,48,55].…”

Section: Discussionmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Thompson

Herrera

Lau³

2017

Head and Neck Pathol

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Thyroglossal duct cyst (TGDC) carcinomas are rarely encountered in the pediatric population. The clinical behavior of these tumors in the pediatric setting is unclear and management is not well defined. Two cases of pediatric thyroglossal duct cyst carcinoma were identified in a review of all thyroglossal duct cysts diagnosed over a ten year period. These two cases were analyzed along with 57 cases of thyroglossal duct cyst carcinoma affecting patients less than 21 years of age compiled from the English literature. Fifty-nine patients (36 females, 23 males) aged 6-20 years (mean 15.0 years) were identified. All presented with an anterior midline neck mass, which was typically mobile and non-tender. The average tumor size was 2.6 cm. Histologically, all tumors were papillary thyroid carcinomas arising in a background of a thyroglossal duct cyst. The tumors exhibited a papillary, follicular, or mixed architecture with classical papillary thyroid carcinoma nuclear features. Soft tissue extension was present in 16 cases. All patients were managed surgically with a Sistrunk procedure, with additional thyroidectomy performed in 29 patients, combined with a lymph node dissection (n = 15), or a Sistrunk and lymph node dissection (n = 5). All patients were stage I at presentation, with 11 showing lymph node metastases. Postoperative radioactive iodine was employed in 20 patients. A papillary carcinoma of the thyroid gland was reported in four of the patients who had concurrent/subsequent thyroidectomies. Recurrences were reported in four patients, with distant metastases in one patient, who died of disease (13 months). Follow up data was available for 45 patients, with an overall mean follow-up of 54.5 months. All patients were alive, with the exception of one who died with disease. TGDC carcinomas in pediatric patients is associated with a good overall prognosis, best managed by Sistrunk procedure alone, with selected lymph node dissection if clinically indicated.

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Primary Papillary Carcinoma in Thyroglossal Cysts. Case Reports and Literature Review

Cited by 11 publications

References 13 publications

Papillary carcinoma of the thyroid in a thyroglossal cyst-a rare incidental finding

Papillary carcinoma of the thyroid in a thyroglossal cyst-a rare incidental finding

Papillary Carcinoma Thyroid in Thyroglossal Cyst- A Case Report

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

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