Primary osteosarcoma of the head and neck in pediatric patients

Gadwal, Shyam R.; Gannon, Francis H.; Fanburg‐Smith, Julie C.; Becoskie, Elizabeth M.; Thompson, Lester D.�R.

doi:10.1002/1097-0142(20010201)91:3<598::aid-cncr1040>3.3.co;2-4

Cited by 22 publications

(9 citation statements)

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“…Anatomopathological analysis of tumour biopsy confirms only the diagnosis of high-grade osteosarcoma without any prognostic consequence (Dahlin and Unni, 1986;Huvos, 1991). In one study, the site of the primary tumour had no correlation with survival (Nagler et al, 2000), whereas others have reported a significant trend towards survival in the axial or appendicular flat bone high-grade osteosarcomas (Duffaud et al, 2000;Gadwal et al, 2001).…”

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confidence: 98%

Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping

et al. 2003

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At present, the only recognised prognostic factor for primary osteosarcoma is the histological response to preoperative chemotherapy. Our study was designed to identify new diagnostic markers that could eventually have a prognostic value. A total of 54 patients under 20 years of age with primary osteosarcomas were studied while under treatment by the French Society of Paediatric Oncology OS 94 protocol. Paired normal and biopsy samples were collected. In addition, surgical resection specimens, following preoperative chemotherapy, were obtained in 13 cases. After genomic DNA extraction, an allelotyping analysis targeting microsatellites linked to Rb and p53 genes, and 9p21, 7q31 and 5q21 regions was performed. In all, 94% of the samples at diagnosis showed allelic imbalance and the biopsies were highly rearranged except for the microsatellite targeting 7q31. The same panel was highly informative at surgical resection. Microsatellites investigating Rb, p53 and the 9p21 region were particularly altered without a significant correlation with prognosis. On the other hand, the alteration of the 7q31 locus at diagnosis was significantly correlated with a worse prognosis and a new frequently altered locus, 5q21, was described. In conclusion, this panel allowed us to characterise paediatric osteosarcomas. Correlation of prognosis with the altered 7q31 region could be a useful tool and further studies are required to confirm the importance of 5q21.

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confidence: 98%

Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping

et al. 2003

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“…However, primary osteosarcoma of the skull base is rare, about 150 cases reported since 1945 [1][2][3][4][5][6][7][8][9].…”

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confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…However, only 5-10% are located in the craniofacial bones and most common locations are maxilla & mandible [1][2][3][4][5][6][7][8]. Cranial vault osteosarcoma is very rare with occurrence of less than 1% [1][2][3][4][5][6]. The most common radiological findings of osteosarcoma are ill defined osteolytic lesion with wide zone of transition, cortical bone destruction, an aggressive periosteal reaction (speculated, laminated type or Codman's triangle), a soft tissue mass, and a tumor matrix in the destructive lesion.…”

Section: Introductionmentioning

confidence: 99%

“…The most common radiological findings of osteosarcoma are ill defined osteolytic lesion with wide zone of transition, cortical bone destruction, an aggressive periosteal reaction (speculated, laminated type or Codman's triangle), a soft tissue mass, and a tumor matrix in the destructive lesion. Most osteosarcomas are purely osteolytic however few lesions appear as sclerotic or mixed [1][2][3][4][5][6][7][8]. Here we represent a rare case of posterior skull base osteosarcoma with possible two lung metastases.…”

Section: Introductionmentioning

confidence: 99%

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Rare Case Report of Primary Osteosarcoma of the Posterior Skull Base with Lung Metastases in 14 Years Old Female

Solanki¹,

Dave²

2017

OMICS J Radiol

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Osteosarcoma arising from skull base are very rare. We report the case of a 14-year-old female patient who presented with a swelling in the right postauricular region for 6 months, which proved to be a high-grade osteosarcoma. On Chest screening, we found two lung nodules which most likely represent metastases. We describe pre-and post-operative findings on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). We review the literature of reported cases of primary osteogenic sarcomas of the skull to discuss the common clinical presentation, evaluation methods, and recommended treatment plans.

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