Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review

Mujtaba, Bilal; Nassar, Sameh; Aslam, Rizwan; Garg, Naveen; Madewell, John E.; Taher, Ahmed; Hanafy, Abdelrahman K.; Whitman, Gary J.

doi:10.1067/j.cpradiol.2019.01.001

Cited by 12 publications

(13 citation statements)

References 31 publications

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“…Primary osteogenic sarcoma of the breast (POSB) typically presents as a painless mass with no attendant evidence of nipple discharge or retraction [10]. Similar to phyllodes tumours, POSB exhibit rapid growth which may account for the large average size (4.6 cm) at presentation [6,11].…”

Section: Discussionmentioning

confidence: 99%

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Primary Osteosarcoma of the Breast in a Patient Treated Previously for Invasive Ductal Carcinoma: An Unusual Presentation of a Very Rare Primary Breast Malignancy

Milne

Sookar²,

Umakanthan

et al. 2020

Case Reports in Surgery

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Primary osteogenic sarcoma of the breast is a rare clinical entity with few cases described in the literature. Unfortunately, the prognosis for these patients is poor when compared to invasive carcinomas of the breast. We report a case of a 58-year-old female who developed a primary osteogenic sarcoma of the breast five years after being treated for invasive carcinoma of the ipsilateral breast without the use of radiotherapy.

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Section: Discussionmentioning

confidence: 99%

“…The lesion typically appears as a well-defined, hyperdense mass with coarse calcifications. CT plays an important role in excluding a lesion arising from the underlying bony structures as well as identifying distant metastases [10]. Skeletal scintigraphy if done preoperatively can suggest a POSB if increased uptake is noted in the lesion.…”

Section: Discussionmentioning

confidence: 99%

Primary Osteosarcoma of the Breast in a Patient Treated Previously for Invasive Ductal Carcinoma: An Unusual Presentation of a Very Rare Primary Breast Malignancy

Milne

Sookar²,

Umakanthan

et al. 2020

Case Reports in Surgery

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“…Therefore, miR-340 can be used as a biomarker to alleviate the drug resistance of OS. Mujtaba et al [33] examined the expression levels of miR-223 in 20 pairs of OS and non-tumor tissues, and found that the miR-223 expression was significantly downregulated in OS tissues. When MG63 cells were transfected with miR-223 mimics, miR-223 expression was upregulated and the cell proliferation rate was slowed down.…”

Section: Targeting Mirna Molecules Related To Os Drug Resistancementioning

confidence: 99%

Advances in the role of miRNAs in the occurrence and development of osteosarcoma

Zhang

et al. 2020

Open Medicine

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Osteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18–25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS.

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“…The exact mechanism of tumorigenesis of POB remains unknown. Studies suggest that it may occur because of neoplastic transformation in a pre-existing breast lesion (including fibroadenoma, phyllodes tumor, or intraductal papilloma), or it may arise from totipotent mesenchymal cells of the breast stroma ( 2 – 4 ). In this article, we report an 83-year-old female diagnosed with POB in the left breast without histories of any breast lesions and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

Xue

Shi

2022

Front. Oncol.

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BackgroundPrimary osteosarcoma of the breast (POB) is an extremely aggressive and heterogeneous neoplasm that originates from nonepithelial elements of the mammary gland and accounts for fewer than 1% of breast cancers and fewer than 5% of all sarcomas.Case PresentationAn 83-year-old Chinese woman went to our hospital because of a palpable mass she had had for 8 months in the left breast accompanied by persistent dull pain for 10 days. This mass was initially misdiagnosed as a degenerating fibroadenoma and was graded as probably benign (BI-RADS category 3) by ultrasonography (US) and computed tomography (CT) plain scan and contrast enhancement of chest. Eight months later, it was presumed to be highly malignant and graded as BI-RADS category 4C because of its rapid growth and more calcifications by US and CT. 99mTc-MDP whole-body bone imaging showed that there was a mass-like abnormal radioactive concentration of Tc-99m outside the bone of the left chest. The lumpectomy of the left breast was indicated, and the pathological findings were POB. She succumbed to respiratory failure caused by multiple lung metastases 4 months after the operation.ConclusionPOB is rare, and US and CT cannot reliably distinguish the causes of calcified breast masses between benign and malignant tumors. It can be diagnosed by pathology when metaplastic carcinoma, malignant phyllodes tumor, or carcinosarcoma containing osteoid and bone is excluded. This case could help clinicians to improve the prognosis and treatment of this disease.

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Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review

Cited by 12 publications

References 31 publications

Primary Osteosarcoma of the Breast in a Patient Treated Previously for Invasive Ductal Carcinoma: An Unusual Presentation of a Very Rare Primary Breast Malignancy

Primary Osteosarcoma of the Breast in a Patient Treated Previously for Invasive Ductal Carcinoma: An Unusual Presentation of a Very Rare Primary Breast Malignancy

Advances in the role of miRNAs in the occurrence and development of osteosarcoma

Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

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