Primary Osteogenic Sarcoma of the Kidney

Abstract

We report a case of primary osteogenic sarcoma of the kidney. To our knowledge only 7 such cases have been described previously.

Primary Osteosarcoma of the Kidney

“…Physical examination in the majority of cases reveals a palpable stony hard renal mass [1,2,7,8,12,13,15,19,20], Serum alkaline phosphatase can be elevated but is normal in most of the cases [1]. The persistently and extremely elevated serum alkaline phosphatase as well as the moderately raised serum calcium in our case is thought to be indicative of hyperactive bone metabolism.…”

“…The so-called 'sun burst appearance' of calcification within the renal contour is consid ered to be a characteristic radiologic sign [1,20], but several other configurations have been found [2,7,[15][16][17]19], Roentgenologic skeletal survey usually is negative [ 1,15,20], Excretory urogram may show all sequelae of space-occupying lesions, including organ dis placement and hydronephrosis [9,15,16,19]. As to the regional growth behavior, early infiltration of the renal capsule and involve ment of adjacent structures seem to be frequent [1,9,13,15,19]. At the time of diagnosis only one of the tumors was organ-confined [12] and in many cases metastatic spread has been observed.…”

Primary Renal Osteosarcoma

“…It was elevated only in 2 cases [8,10], Various forms of treatment have been used, including surgery, chemotherapy and radiotherapy. Regardless of the therapy provided in the reported cases, this particular sarcoma proved to be highly lethal.…”

Histopathology and Molecular Pathology of Bone and Extraskeletal Osteosarcomas

“…Fewer than 10% are superficial, originating in the dermis or subcutis. Cases of EOs arising in unusual sites have been reported, such as the breast, larynx, thyroid gland, parotid, abdominal viscera, including esophagus, small intestine, omentum majum, liver, heart, the urogenital system, including urinary bladder, ureter the prostate and the penis, pleura, mediastinum, ectopic thymus, pulmonary artery, pilonidal area and aorta (Baydar, et al, 2009;Burke & Virmani, 1991;Kemmer et al, 2008;Loose et al, 1990;Micolonghi et al, 1984;Piscioli et al, 1985;Shui et al, 2011;Silver & Tavassoli, 1998;Trowell & Arkell, 1976;Young & Rosenberg, 1987;Wegner et al, 2010;Greenwood & Meschter, 1989). Fewer than 300 cases have been reported to date and their aetiology is essentially unknown.…”