Primary Oral Malignant Melanoma

Boulaadas, Malik; Benazzou, Salma; Mourtada, Faissal; Sefiani, S.; Nazih, N; Essakalli, Leila; Kzadri, M.

doi:10.1097/scs.0b013e3180f6120e

Cited by 19 publications

(6 citation statements)

References 11 publications

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“…This explains the lower frequency of melanoma in these locations. Although their function is not fully understood, the presence of melanocytes in the mucous membranes is well established (1, 6).…”

Section: Pathophysiologymentioning

confidence: 99%

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Oral malignant melanoma: a review of the literature

Femiano

Lanza

Buonaiuto

et al. 2008

J Oral Pathology Medicine

106

116

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Primary oral melanoma (POM) is an uncommon malignant tumor that originates from the proliferation of melanocytes. Such tumors can be present at any location in the oral cavity; however, it affects more frequently the hard palate and the maxillary alveolar mucosa. POM is usually asymptomatic in the early stages and it presents normally as a pigmented patch or as a mass with a rapid growth rate. In the advanced stages, it can show ulceration, swelling, bleeding, rapid enlargement and loosening of teeth. Melanoma of the mouth is rare, most commonly occurring in the upper jaw of patients more than 65 years. Because of a frequent delay in diagnosis, the tumors are often diagnosed when they are deeper than the average cutaneous melanoma. The prognosis is extremely poor, especially in advanced stages. Therefore, pigmented lesions of undetermined origin should be routinely subjected to a biopsy examination. In this study, we aimed to present a review on primary malignancy.

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Section: Pathophysiologymentioning

confidence: 99%

“…A melanoma is a malignant tumor comprising melanocytes, which are cells derived from the neural crest that constitute the melanin pigment in the basal layer of epithelium. Although most melanomas arise in the skin, they may also arise from mucosal surfaces or at other sites wherein neural crest cells migrate (1, 2).…”

Section: Introductionmentioning

confidence: 99%

Oral malignant melanoma: a review of the literature

Femiano

Lanza

Buonaiuto

et al. 2008

J Oral Pathology Medicine

106

116

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“…Oral malignant melanomas are extremely rare lesions and occur commonly in the maxillary gingival and palatal region. Malignant melanoma is the third most common skin malignancy, yet it comprises of only 3 to 5% of all cutaneous malignancies (Boulaadas et al, 2007). Malignant melanomas of the oral cavity are extremely rare accounting for 0.2-8% of all malignant melanomas (Ebenezer, 2006;Guevara-Canales et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Oral Malignant Melanoma: A Case Report

Sen

Kumari³

et al. 2021

Prague Med. Rep.

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Melanoma is a malignant neoplasm of the epidermal melanocytes. Awareness and early recognition of pigmented lesion inside oral cavity helps in initial diagnosis and further investigation and treatment. Oral malignant melanoma is a rare aggressive neoplasm commonly seen among middle age. The diagnosis of melanoma initiates from the pre-existing pigmented lesions. The poor prognosis of oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied. A case of malignant melanoma of hard palate with its clinical, radiological and histopathological presentation along with brief review is presented. Prognosis of these lesion is poor with survival rate of 5 years.

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“…However, human OMMs are also aggressive rapidly growing, invasive tumours that display metastatic rates of 66% (regional lymph nodes 22 ), 53% (lung 23 ), 36% (bone 23 ), and 20% (liver and brain 23 ), respectively. The 5-year survival rate is 15–25% 22,24 . Advanced human mucosal melanoma also has a low rate of response to adjuvant chemotherapy 25 .…”

Section: Introductionmentioning

confidence: 99%

Genome-wide analysis of canine oral malignant melanoma metastasis-associated gene expression

Blacklock

Birand

Selmic

et al. 2019

Sci Rep

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Oral malignant melanoma (OMM) is the most common canine melanocytic neoplasm. Overlap between the somatic mutation profiles of canine OMM and human mucosal melanomas suggest a shared UV-independent molecular aetiology. In common with human mucosal melanomas, most canine OMM metastasise. There is no reliable means of predicting canine OMM metastasis, and systemic therapies for metastatic disease are largely palliative. Herein, we employed exon microarrays for comparative expression profiling of FFPE biopsies of 18 primary canine OMM that metastasised and 10 primary OMM that did not metastasise. Genes displaying metastasis-associated expression may be targets for anti-metastasis treatments, and biomarkers of OMM metastasis. Reduced expression of CXCL12 in the metastasising OMMs implies that the CXCR4 / CXCL12 axis may be involved in OMM metastasis. Increased expression of APOBEC3A in the metastasising OMMs may indicate APOBEC3A -induced double-strand DNA breaks and pro-metastatic hypermutation. DNA double strand breakage triggers the DNA damage response network and two Fanconi anaemia DNA repair pathway members showed elevated expression in the metastasising OMMs. Cross-validation was employed to test a Linear Discriminant Analysis classifier based upon the RT-qPCR-measured expression levels of CXCL12 , APOBEC3A and RPL29 . Classification accuracies of 94% (metastasising OMMs) and 86% (non-metastasising OMMs) were estimated.

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Primary Oral Malignant Melanoma

Cited by 19 publications

References 11 publications

Oral malignant melanoma: a review of the literature

Oral malignant melanoma: a review of the literature

Oral Malignant Melanoma: A Case Report

Genome-wide analysis of canine oral malignant melanoma metastasis-associated gene expression

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