Primary oncocytic carcinoma of the salivary glands: A clinicopathologic and immunohistochemical study of 12 cases

Zhou, Chuan‐Xiang; Shi, Dian-Yin; Ma, Dan; Zhang, Jianguo; Yu, Guang‐Yan; Gao, Yan

doi:10.1016/j.oraloncology.2010.07.014

Cited by 37 publications

(37 citation statements)

References 18 publications

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“…With the exception of papillary cystadenoma lymphomatosum (Warthin tumor), salivary gland tumors with prominent oncocytic features are uncommon, and include oncocytoma, oncocytic carcinoma, and oncocytic cystadenoma, as well as oncocytic variants of pleomorphic adenoma, myoepithelioma, mucoepidermoid carcinoma, and epithelial-myoepithelial carcinoma [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Lau

Thompson

2014

Head and Neck Pathol

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Oncocytic lipoadenoma is an exceedingly uncommon neoplasm of the salivary gland composed of oncocytic epithelium and adipose tissue. Retrospective. Seven cases of oncocytic lipoadenoma were analyzed in order to further characterize the clinical and pathologic features of this rare tumor. The patients included six males and one female who ranged from 40 to 83 years of age (mean 62 years) at presentation. All tumors arose in the parotid gland. Grossly, the tumors were solitary, well circumscribed and had light brown to yellow cut surfaces. Histologically, the tumors were composed of an admixed population of oncocytes and adipocytes in varying proportions, with the lipomatous component ranging from 5 to 70 %. Other common features included the presence of serous acini, ductal elements, sebaceous glands, and a patchy chronic inflammation. Clinical follow up information, available in all cases, with a duration of 3-148 months (mean 57 months), showed no evidence of tumor recurrence. Due to its rarity, oncocytic lipoadenoma can pose problems in diagnosis, although the distinctive morphologic features of this neoplasm allow for separation from more commonly recognized oncocytic neoplasms of the salivary glands.

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Section: Introductionmentioning

confidence: 99%

Oncocytic Lipoadenoma of the Salivary Gland: A Clinicopathologic Analysis of 7 Cases and Review of the Literature

Lau

Thompson

2014

Head and Neck Pathol

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“…[5] As for chemotherapy, it is rarely considered in symptomatic patients, due to its low efficacy. [20] …”

Section: Discussionmentioning

confidence: 99%

Submandibular oncocytic carcinoma

Xiao

Wen²,

Liu³

2016

Medicine

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Background:Oncocytic carcinoma (OC) arising in the submandibular gland is an unusual malignant neoplasm, with <20 cases previously reported. The cancer is characterized by numerous morphologically abnormal mitochondria present in the cytoplasm and marked cellular pleomorphism. At its most severe, the tumor may invade into the surrounding tissues, including intravascular, lymphatic, or perineural invasion, and lead to regional nodal or distant metastasis.Methods:The current study describes a novel OC case in a 46-year-old male, the youngest case of the review. The patient presented with a 5-month history of an intermittently painful mass.Results:Following magnetic resonance imaging, excisional biopsy, hematoxylin-eosin staining, phosphotungstic acid-hematoxylin staining, and immunohistochemical examination, an OC of the submandibular gland was diagnosed.Conclusion:The current study summarizes the pathogenesis, diagnosis, therapeutics, and the prognosis of OC. The literature review regarding this rare disease is also presented to emphasize the lack of specific markers of OC and the risk of cervical lymph metastasis.

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“…4), CK10/13, CK19, and EMA, whereas there is no reactivity documented for SMA or S-100 ( fig. 5-7) [28]. In addition, there is an increased expression of MIB-1 antibody against Ki-67 antigen in contrast to benign oncocytomas ( fig.…”

Section: Introductionmentioning

confidence: 97%

“…Adjuvant radiotherapy has also been used for the treatment of oncocytic carcinoma [6,14,15,23]. In Zhou et al [28] study, 5 of 12 patients received radiotherapy, of whom two had multiple metastases and died of disease about 1 year after initial treatment, 2 patients are alive with disease 6 and 42 months after treatment but both with recurrence occurred, and only one is alive without evidence of disease 77 months after treatment. Altogether, for the extensive tumors, radical resection combined with elective neck dissection may be the first choice for treatment, while the role of radiotherapy or chemotherapy is still controversial.…”

Section: Introductionmentioning

confidence: 99%