Primary nucleation induced by ultrasonic cavitation

Virone, C.; Kramer, Herman J. M.; Rosmalen, G.M. van; Stoop, A.H.; Bakker, T.W.

doi:10.1016/j.jcrysgro.2006.05.025

Cited by 109 publications

(69 citation statements)

References 10 publications

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“…Ultrasound has been widely reported to influence the primary nucleation process accelerating nucleation kinetics, this is typically expressed in terms of reducing the induction time and MSZW [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Ultrasound can also increase the rate of secondary nucleation, this is manifested as a reduction on the product crystal size distribution [20,22,24,31,32,[34][35][36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

et al. 2017

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Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield) and crystal properties (crystal size distribution determined by Focused Beam Reflectance Measurement (FBRM), crystal habit, filtration rate and impurity content in the crystal product by Liquid Chromatography-Mass Spectroscopy (LC-MS)) were investigated in bulk suspension crystallisation experiments with and without the use of ultrasound. The results demonstrate that ultrasonic intervention has a significant effect on both crystallisation and product crystal properties. It increases the nucleation rate resulting in smaller particles and a narrower Particle Size Distribution (PSD), the yield has been shown to be increase as has the product purity. The effect of ultrasound is to reduce the level acetanilide impurity incorporated during growth from a 2 mol% solution of the selected impurity from 0.85 mol% to 0.35 mol% and likewise ultrasound reduces the uptake of metacetamol from 1.88 mol% to 1.52 mol%.

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Section: Introductionmentioning

confidence: 99%

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

et al. 2017

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“…In most of the publications concerning the ultrasonic nucleation phenomenon, cavitation induced by ultrasound plays a major role (Guo et al 2006a,b;Hem, 1967;Kim et al, 2003;Lyczko et al, 2002;Virone et al, 2006). Hem (1967) gave an overview of assumptions and argumentations concerning the impact of power ultrasound on the crystallization process.…”

Section: Introductionmentioning

confidence: 99%

“…He noted that the latter three cannot sufficiently explain the ultrasonic mechanism. Virone et al (2006) assumed that high pressures in cavities as bubbles collapse during ultrasonic irradiation lead to an increased driving force. They applied the classical theory for homogenous nucleation and calculated the nucleation rates under this assumption.…”

Section: Introductionmentioning

confidence: 99%

Modeling ultrasound-induced nucleation during cooling crystallization

Kordylla

Krawczyk

Tumakaka

et al. 2009

Chemical Engineering Science

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“…They also reviewed the developments in scale-up methods and available equipment. Virone et al (2006) addressed the relationship between collapse pressure of the cavitating bubbles and solute nucleation rate. Guo et al (2005) studied the effect of ultrasound on primary nucleation by measuring the induction time and metastable zone width.…”

Section: Introductionmentioning

confidence: 99%