Primary non-Hodgkin's lymphomas of the central nervous system

Merkel, K. H. H.; Hansmann, M. L.

doi:10.1016/s0344-0338(86)80078-4

Cited by 19 publications

(3 citation statements)

References 13 publications

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“…However, Helle et al [3], in a statistical analysis of 22 cases of PCNSL, found a poorer prognosis in the patients with a diffuse mixed lymphoma histology. This cytotype supports the idea of a follicular origin and is seldom found within the CNS [9]. phoma consists of more than one disease group and that tumor histology might be an important prognostic factor.…”

Section: Case Relmrtsupporting

confidence: 84%

Primary central nervous system lymphoma: a case of long survival

et al. 1988

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Despite combined treatment (surgery, radio--and chemotherapy) primary central nervous system lymphoma (PCNSL) has generally a poor prognosis. Long surviving cases (more than 5 years) are exceptional. We report a case of a patient completely symptom-free 79 months after craniotomy. Histological diagnosis was diffuse centroblastic-centrocytic malignant lymphoma. Immunohistological study of the lesion was performed. Repeated CT scans reveal no tumor recurrence and screenings for extraneural disease remain negative. The prognostic value of tumor histology is emphasized.

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Section: Case Relmrtsupporting

confidence: 84%

Primary central nervous system lymphoma: a case of long survival

et al. 1988

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“…The data on low-grade PCNSL is limited to a few case reports (Mikol et al, 1987;King et al, 1998;Braks et al, 2000) and pathological series (Jellinger et al, 1975;Bogdahn et al, 1986;Merkel & Hansmann, 1986;Simon et al, 1987;Kanav- 1990;Bergmann et al, 1993;Ferracini et al, 1993). Braks et al (2000) reported a 42-year-old woman with a 3-year history of headaches and vertigo and a 1-year history of seizures.…”

Section: Discussionmentioning

confidence: 99%

“…Their survival ranged from 12 d to 25+ months. Low-grade PCNSL cases that were included in other pathological series (Jellinger et al, 1975;Merkel & Hansmann, 1986;Simon et al, 1987;Bergmann et al, 1993;Ferracini et al, 1993) were mostly lymphoplasmacytoid immunocytomas, and no detailed description was provided. T-cell histology has been reported in <4% of PCNSL patients from Western countries (Bataille et al, 2000) and in 8AE5% from Japan (Hayabuchi et al, 1999) where some patients are positive for the human T-lymphotropic virus type 1.…”

Section: Discussionmentioning

confidence: 99%

Low‐grade primary central nervous system lymphoma in immunocompetent patients

et al. 2005

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SummaryPrimary central nervous system lymphomas (PCNSL) are usually diffuse large B-cell non-Hodgkin's lymphomas (NHL). Here we characterize the clinical presentation, course and outcome of patients with low-grade PCNSL. Records of 332 patients screened for inclusion in three multicentre prospective trials were reviewed. Ten patients (3%) with a median age of 59 years and a median Karnofsky performance status of 70% were identified. Seven patients had B-cell and three had T-cell lymphoma. The median growth fraction was 4%. The radiological morphology was unusual for PCNSL in eight patients. Three patients underwent complete tumour resection, combined with chemotherapy in one patient and with chemotherapy plus local radiotherapy in another. Four patients received chemotherapy and three received chemotherapy plus whole-brain irradiation, resulting in four complete remissions, two no-change situations and one progressive disease. Patients had an overall survival (OAS) of 2-58+ months with a 2-year OAS of 67%. Low-grade PCNSL may differ from classical high-grade PCNSL in its clinical features and radiological morphology. The clinical course may be variable and frequently more indolent than in classical PCNSL.

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Primary central nervous system lymphomas. Immunophenotypic, virologic, and cytogenetic findings of three patients without immune defects

Itoyama

Sadamori

Tsutsumi

et al. 1994

Cancer

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Background. Primary central nervous system (PCNS) lymphoma is a relatively rare disease, but an increasing incidence is reported. The Epstein‐Barr virus (EBV), which is often found in lymphomas of immuno‐compromised patients, has been implicated in the development of lymphomas. Many cytogenetic analyses of nodal B cell lymphomas have been performed, but few studies on PCNS lymphomas have been reported. Methods. The detection of EBV genome using the polymerase chain reaction (PCR) method and cytogenetic studies were performed, in addition to histopathologic and immunophenotypic approaches in biopsied tissue from three patients with PCNS lymphoma. Immunosuppressive states and exposure to mutagens were not clear in all patients. Results. Histopathologic examination disclosed a diffuse type of malignant lymphoma in all patients. Immunophenotypic studies revealed B cell phenotype in all patients, two of whom showed positive reaction for CD5. The PCR method revealed no involvement of EBV genome in tumors in any patients. The cytogenetic study showed clonal chromosome abnormalities in all patients, and abnormalities of chromosome 1 (1q21), 6 (‐6, 6q15 and 6q21), 7 (‐7 and 7p15), and 14 (14q24 and 14q32) were prominent. The t(6;14)(q15;q32) observed in Patient 1 is the first case to be reported in human de novo lymphoma. Conclusions. These findings indicate that the causative role of EBV in PCNS lymphoma without immune defects is not clear. The cytogenetic findings were similar to those observed in nodal B‐cell lymphoma, suggesting that the origin of PCNS lymphoma cells does not differ from nodal B cell lymphoma cells cytogenetically.

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Primary non-Hodgkin's lymphomas of the central nervous system

Cited by 19 publications

References 13 publications

Primary central nervous system lymphoma: a case of long survival

Primary central nervous system lymphoma: a case of long survival

Low‐grade primary central nervous system lymphoma in immunocompetent patients

Primary central nervous system lymphomas. Immunophenotypic, virologic, and cytogenetic findings of three patients without immune defects

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