Primary Non-Adherence to Antihistamines—Conclusions From E-Prescription Pilot Data in Poland

Kardas, Grzegorz; Panek, Michał; Kuna, Piotr; Cieszyński, Janusz; Kardas, Przemysław

doi:10.3389/fphar.2020.00783

Cited by 9 publications

(9 citation statements)

References 46 publications

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“…The actual degree of drug use is modified by patient adherence, which varies from over-to underuse of prescribed drugs. Fortunately, the data analyzed by us, i.e., dispensation data, are not biased by primary non-adherence, which was recently found, in other studies conducted by our group, to reach the overall level of 20.8% (Kardas et al, 2019), with some drug groups reaching even higher values (e.g., 31.3% in antihistamines (Kardas et al, 2020)). On the other hand, real-world drug use is affected by secondary non-adherence, which in Poland in some cases reached the level of over 80% (Kardas, 2011).…”

Section: Discussionsupporting

confidence: 59%

Prevalence and Age Structure of Polypharmacy in Poland: Results of the Analysis of the National Real-World Database of 38 Million Citizens

Kardas

Urbański²,

Lichwierowicz³

et al. 2021

Front. Pharmacol.

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Introduction: Polypharmacy is a risk factor for adverse health outcomes, higher use of medical services and additional costs. The problem has gained attention as a consequence of aging and related multimorbidity. Therefore, there is an urgent need to adopt effective interventions aimed at reducing its burden. In order to achieve this, in-depth understanding of the prevalence of polypharmacy is required. Of particular interest is, however, assessing prevalence of polypharmacy in various age groups, to reach the right target for these interventions. So far, only limited data on polypharmacy among non-elderly individuals have been available.Aim of study: To assess overall prevalence of polypharmacy in Poland as well as its distribution in various age groups using real-world data.Methodology: A retrospective analysis of complete dispensation data of national payer organization for the years 2018–2019. The analyzed dataset included data on dispensation of reimbursed drugs, and exclusively for 2019, also non-reimbursed drugs. Polypharmacy was defined as dispensation of ≥5 prescription medications within six months.Results: In the analyzed national cohort of 38 million Polish citizens, the prevalence of polypharmacy was found to be 11.7% in 2018 and 11.6% in 2019. With age, the prevalence of polypharmacy increased, reaching the value of 56.0% in those aged 80+ in 2018, and 55.0% in 2019. Altogether, among those aged 65+, the polypharmacy was present in 43.1% in 2018, and 42.1% in 2019. In the youngest group of citizens, i.e., among those aged below 20 years, polypharmacy was found in 0.9%, and 0.8% in 2018 and 2019, respectively. Prevalence of polypharmacy, calculated for 2019 according to dispensation of five or more reimbursed and non-reimbursed drugs for the whole Polish population, was 21.8% for January-June, and 22.4% for July-December 2019. Among those aged 65+, the relevant numbers were 62.3%, and 62.9%, respectively.Conclusion: This study, being the first nationwide assessment of polypharmacy in Poland, confirmed its high prevalence. We found polypharmacy present in over one fifth of Polish society. Peaking in the elderly, polypharmacy occurred in each age group. These results lay the foundations for future interventions focused on reducing the scope of this problem in Poland.

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Section: Discussionsupporting

confidence: 59%

Prevalence and Age Structure of Polypharmacy in Poland: Results of the Analysis of the National Real-World Database of 38 Million Citizens

Kardas

Urbański²,

Lichwierowicz³

et al. 2021

Front. Pharmacol.

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“…The prevalence of PNA is consistent with what has been documented in other studies of PNA in dermatology patients. 2,11 Primary non-drug adherence was noted more in females. This may be because there were more females than males in the study in keeping with females being reported to attend clinics more than males.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to our study, a younger age has been linked to PNA. 2,10,11,15 Moo-Young et al did not find age to be associated with PNA. 5 Moo-Young et al specifically looked at distance to the pharmacy as a risk for PNA in the United States of America where a means of transportation is not a problem and pharmacies are located in the neighbourhoods.…”

Section: Limitationsmentioning

confidence: 93%

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Primary drug non-adherence in dermatology patients: prevalence, pattern and reasons

Anaba

Arabambi²

2022

Int J Res Dermatol

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Background: Primary drug non-adherence, a pervasive problem in dermatology is not readily documented despite the adverse effect of this phenomenon on the management of patients. The aim of the study was to document the prevalence, pattern and reasons for primary drug non-adherence in dermatology patients.Methods: This prospective cross-sectional questionnaire based study was conducted from June to December 2021 amongst 302 consecutive consenting adult patients returning to the dermatology clinic following an initial diagnosis and a prescription for medications. Data collected included socio-demographic parameters, primary drug adherence, and number of drugs prescribed, number not purchased, and reason for non-adherence. Data analysis was done in R Studio [R Core Team (2021)].Results: Three hundred and two (302) patients aged 13 to 87 years with a mean age of 41.72±18.8 years were recruited into the study. Prevalence of primary non-drug adherence was 26.2% (79/302). Amongst the non-adherent patients; 73.4% were females and 26.6% were males. The reasons for non-drug adherence ranged from non-availability of drug (63.3%) to patient forgetting about the prescription. (1.3%). Route of drug not adhered to was Topical in 72%, Oral in 22.7%, oral and topical in 5.3.Conclusions: Primary drug non-adherence is common with dermatology patients. The propensity for primary non-drug adherence is increased when the number of drugs prescribed are more than three. Dermatologists need to consider the use of drugs capable of addressing multiple symptoms and thereby reduce the number of drugs prescribed.

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“…The non‐adherence to these drugs was lower than obtained in our previous study on drivers of general non‐adherence in Poland, where for drugs in 6 major areas (antidiabetic, antithrombotic, cardiovascular, cholesterol medications, antibiotics and psychiatric drugs) the primary non‐adherence was 20.8% [31 ]. Also, it was lower than of that for antihistamine drugs, for which the level of primary non‐adherence was 21% [32 ].…”

Section: Discussionmentioning

confidence: 99%

Primary non-adherence to inhaled medications measured with e-prescription data from Poland

Kardas

Panek

Kuna

et al. 2020

Clin Transl Allergy

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Background Treatment adherence greatly influences the clinical outcomes in various fields of medicine, including management of asthma and COPD. With the recent implementation of a nationwide e-Health solutions in Poland, new and unique opportunities for studying primary non-adherence in asthma and COPD emerged. The aim was to study primary non-adherence to inhaled medications available in Poland indicated in asthma and/or COPD and analyse the impact of patients’ demographics and inhalers’ characteristics (dry powder inhalers (DPIs) vs metered dose inhalers (MDIs) and presence of a dosage counter) on primary non-adherence. Methods A retrospective analysis of all e-prescriptions issued in Poland in 2018 (n = 119,880) from the national e-prescription pilot framework. Results Primary non-adherence for inhalable medications reached 15.3%. It significantly differed among age groups—the lowest (10.8%) was in 75 + years-old patients, highest (18%) in 65–74 years-old patients. No gender differences in primary non-adherence were found. The highest non-adherence was observed for ICS + LABA combinations (18.86%). A significant difference was found between MDI and DPI inhalers and between inhalers with/without a dosage counter. Conclusions Out of e-prescriptions for inhaled medications issued in 2018 in Poland, 15.3% were not redeemed. The degree of primary non-adherence was influenced by age, but not gender. Significant differences between MDIs and DPIs and between inhalers with/without a dosage counter were observed.

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Primary Non-Adherence to Antihistamines—Conclusions From E-Prescription Pilot Data in Poland

Cited by 9 publications

References 46 publications

Prevalence and Age Structure of Polypharmacy in Poland: Results of the Analysis of the National Real-World Database of 38 Million Citizens

Prevalence and Age Structure of Polypharmacy in Poland: Results of the Analysis of the National Real-World Database of 38 Million Citizens

Primary drug non-adherence in dermatology patients: prevalence, pattern and reasons

Primary non-adherence to inhaled medications measured with e-prescription data from Poland

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