Primary mucosal melanoma of the palatine tonsil: Report of a case and review of the literature

Osorio, Marcela; Moubayed, Sami P.; Hernández-Prera, Juan C.; Scott, John C.; Urken, Mark L.

doi:10.1016/j.amjoto.2017.04.010

Cited by 8 publications

(10 citation statements)

References 17 publications

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“…Symptoms associated with tonsillar melanomas include dysphagia, odynophagia and bleeding. Presentation with cervical lymphadenopathy secondary to metastasis to regional nodes, as in our patient’s case, is also common [ 3 ]. Around 19% of patients with head and neck mucosal melanoma present with regional lymph node metastases, and 10% with distant metastases [ 7 ].…”

Section: Discussionmentioning

confidence: 91%

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An unusual pigmented tonsil neoplasm presenting to Head & Neck Clinic: a case report and literature review of primary tonsillar malignant mucosal melanoma

Rae

Bates

Fraser

2022

Journal of Surgical Case Reports

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Primary mucosal melanoma of the tonsil is rare, with 27 reported cases. Careful diagnosis is necessary, as the tonsil is more often a site of metastatic melanoma from a cutaneous primary tumour. In this report, we present a case of primary right tonsillar mucosal melanoma with widespread metastasis in a 31-year-old man who presented with a 3-month history of enlarging neck lumps. On examination, he had cervical lymphadenopathy and a pigmented, vascular lesion of his right tonsil, which was diagnosed as melanoma following investigation. He had widespread metastases upon presentation, and is currently undergoing palliative immunotherapy. Owing to the aggressive behaviour, late presentations and lack of effective treatment to cure mucosal melanomas, they have a poor prognosis. Treatment involves wide local excision in local disease, and immunotherapy as the first-line for metastatic disease.

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Section: Discussionmentioning

confidence: 91%

“…Mucosal melanomas can arise from any mucosal membrane, but 55% occur in the head and neck region [ 2 ]. The tonsil, however, is a rare site for a primary mucosal melanoma, with only 27 cases having been reported in the literature [ 3 ]. This report presents a case of a primary mucosal melanoma of the right palatine tonsil.…”

Section: Introductionmentioning

confidence: 99%

An unusual pigmented tonsil neoplasm presenting to Head & Neck Clinic: a case report and literature review of primary tonsillar malignant mucosal melanoma

Rae

Bates

Fraser

2022

Journal of Surgical Case Reports

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“…e There is no tumor reactivity for AFP. f There is a strong nuclear reaction with MIB1, yielding a proliferation index of about 70% sarcoma, melanoma, various salivary gland primaries, and metastatic tumors) can occur at this site, substantially expanding the differential diagnosis [26][27][28]30].…”

Section: Discussionmentioning

confidence: 99%

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

Payne

Palma

Walker

et al. 2020

Head and Neck Pathol

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Extragonadal non-gestational choriocarcinoma is a rare but well-described phenomenon occurring in patients with midline germ cell tumors. Choriocarcinoma (ChC) is an aggressive neoplasm usually developing in women as a rare complication of pregnancy. In male patients ChC occurs in the testes, usually as a component of mixed germ cell tumors. Very few patients develop extragonadal choriocarcinoma with the tumor occurring in midline locations, such as the mediastinum, retroperitoneum, and central nervous system (mostly pineal gland). Non-midline choriocarcinoma can occur in the lung, gastrointestinal tract, and breast, sometimes blended with another primary malignancy. A midline choriocarcinoma manifesting as a head and neck malignancy is exceptional. During an evaluation of multiple enlarged cervical lymph nodes suspected to be lymphoma in a 72-year-old man, a core biopsy was taken from one of the left neck lymph nodes which histologically showed a necrotic malignancy with strong diffuse pancytokeratin staining. After an initial interpretation of metastatic carcinoma, further samples were taken from both tonsils and from a right level 5 neck lymph node. Histologically, all samples contained the same tumor, showing profound pleomorphism and multinucleated syncytial-type giant cells. A panel of immunohistochemistry studies were performed, including β-human chorionic gonadotropin, with positive findings leading to a diagnosis of extragonadal non-gestational choriocarcinoma.

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“…Proton therapy has also been used with success in adjuvantly treating MM of the palatine tonsil after partial pharyngectomy with left level I-V neck dissection. This patient was free of disease 11 months after surgery and 8 months after RT [ 73 ].…”

Section: Mucosal Melanomamentioning

confidence: 99%

The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

Ebner

Malouff

Frank

et al. 2021

International Journal of Particle Therapy

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Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.

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Primary mucosal melanoma of the palatine tonsil: Report of a case and review of the literature

Cited by 8 publications

References 17 publications

An unusual pigmented tonsil neoplasm presenting to Head & Neck Clinic: a case report and literature review of primary tonsillar malignant mucosal melanoma

An unusual pigmented tonsil neoplasm presenting to Head & Neck Clinic: a case report and literature review of primary tonsillar malignant mucosal melanoma

Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation

The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

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