Primary Mucosal Melanoma of Head and Neck: Prognostic Value of Clear Margins

Abstract

The present study suggests that obtaining clear margins must be the goal in the treatment of MMNH.

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

“…Most locoregional failure occurred within the first 24 months after the treatment. 2,6,7,15,17,25,32,40,42 Furthermore, 25% to 77% of all patients in recent reported series developed distant failure following the initial treatment. Similarly, the most distant failures occurred within 2 years.…”

“…12,13 Sinonasal melanoma tends to have a high rate of locoregional and distant failure and to carry poor outcome with a median survival of 9-52 months and an overall 5-year survival rate of 0% to 50%. [4][5][6][7][8] To date, more than one thousand cases of sinonasal melanomas have been reported in the literature. [4][5][6][7][8] Sinonasal mucosal melanoma is a tumor that usually occurs in the seventh decade of life and rarely before the fourth decade, as found in our study.…”

“…[4][5][6][7][8] To date, more than one thousand cases of sinonasal melanomas have been reported in the literature. [4][5][6][7][8] Sinonasal mucosal melanoma is a tumor that usually occurs in the seventh decade of life and rarely before the fourth decade, as found in our study. In the present study, the mean and median age of our patients was 65 years, which is consistent with the results of the literature review in which average mean age of 683 patients in the reported series was 64.5 years.…”

“…1,5,6 The treatment of choice in mucosal malignant melanoma is surgery followed by radiotherapy, particularly in cases of small or doubtful margins of resection. 7 The prognosis of mucosal malignant melanoma is poor with 0% to 50% of 5-year survival. 1,7,8 Herein, we describe 18 cases of sinonasal mucosal melanoma and review the major previous reported series including more than 1000 patients with sinonasal mucosal melanoma.…”

“…7 The prognosis of mucosal malignant melanoma is poor with 0% to 50% of 5-year survival. 1,7,8 Herein, we describe 18 cases of sinonasal mucosal melanoma and review the major previous reported series including more than 1000 patients with sinonasal mucosal melanoma.…”