Primary mucosal malignant melanoma of middle ear — A case report

Abstract

Primary mucosal malignant melanoma reported in this case is a rare clinical entity. Very few cases of primary mucosal malignant melanoma of middle ear have been reported in the literature till date. The etiopathology, clinical features and management of this disease has been described here.

Response to PD‐1 blockade in a patient with mucosal melanoma of the middle ear: Case report

“…Of primary malignant melanomas, a tumor originating in the middle ear is rare with only 12 reports to date. [1][2][3][4][5][6][7][8][9][10][11][12] Early manifestations of this tumor are hearing difficulty and otorrhea. Most are misdiagnosed as serous otitis media.…”

“…Primary mucosal malignant melanomas of the head and neck are relatively rare with most primary lesions generally found in the nasal cavity, paranasal sinuses, oral cavity, and pharyngeal mucosa. Primary mucosal malignant melanomas of the middle ear are extremely rare, described in only a few case reports worldwide 1‐12 . Since the outcomes of current treatment options for mucosal melanomas are poor, a novel approach is required to treat mucosal malignant melanomas of the middle ear.…”

“…Primary mucosal malignant melanomas of the middle ear are extremely rare, described in only a few case reports worldwide. [1][2][3][4][5][6][7][8][9][10][11][12] Since the outcomes of current treatment options for mucosal melanomas are poor, a novel approach is required to treat mucosal malignant melanomas of the middle ear. Immune checkpoint inhibitors have recently been reported to be effective in treating many types of cancer, especially cutaneous melanoma.…”

Primary Middle Ear Mucosal Melanoma: Case Report and Comprehensive Literature Review of 21 Cases of Primary Middle Ear and Eustachian Tube Melanoma

“…A detailed literature review was performed with a total of 21 cases of middle ear or ET MM. 4-22 Three cases with incomplete information were excluded. 23,24 Of the 21 total cases identified (Table 1), 10 arose in the middle ear (47.6%) and 11 in the ET (52.4%).…”

Extracellular and intracellular melanin in inflammatory middle ear disease

“…Although Lin showed melanocytes scattered in the lamina propria of the middle ear mucosa in 10/50 cadaveric specimens, Navarrete only found melanin and melanocytes in the inner ear when examining 48 normal temporal bones . Reports of primary malignant melanoma of the middle ear mucosa support the hypothesis that melanocytes are present in the middle ear . Of importance, extracellular melanin and melanin‐containing histiocytes have not been reported in the middle ear.…”