Primary Mucosal and Glans Penis Melanomas: The Sydney Melanoma Unit Experience

Larsson, Kbm; Shaw, Helen M.; Thompson, John F.; Harman, Richard; McCarthy, William H.

doi:10.1046/j.1440-1622.1999.01497.x

Cited by 37 publications

(10 citation statements)

References 40 publications

(94 reference statements)

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“…MM arising in the genital area is rare, we had only a few cases, but our results confirm the findings in other population that show a higher frequency of MM in the genital area in females than males [15, 20]. On the other hand, oncogenic human papillomavirus (HPV) types such as HPV 16, has been detected in two cases of vulvar MM.…”

Section: Resultssupporting

confidence: 89%

Malignant melanoma in Chile: different site distribution between private and state patients

et al. 2014

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BackgroundThe body site location of primary Malignant Melanoma (MM) has been correlated with prognosis and survival. Ethnic, genetics, sun exposure factors are related to the anatomical distribution of MM. Low and high socioeconomic strata in Chile differ in ethnic, genetic and cultural conditions. The purpose of this study was to analyze the anatomical MM distribution in the Chilean population in both strata searching for differences due to their ethno-genetic-cultural differences. Records of 1148 MM, 575cases from state hospitals (Low Socioeconomic Strata, LSS) and 573 cases from private clinics (High Socioeconomic Strata, HSS) were analyzed by body site.ResultsFemales from LSS showed a higher number of MM in soles, cheeks, and around the eye area. Females from the HSS showed a higher number of MM in dorsal feet and dorsal hands. Males from LSS showed a higher number of MM in soles, around the eye area, and cheeks. However, males from HSS showed a higher number of MM in the trunk, and in the arms. Acral MM was significantly higher in LSS than in the HSS in both sexes. The Chilean population from the HSS and LSS showed differences in the distribution of MM by site. Furthermore, gender differences in the proportion of MM analyzed by anatomical site are observed in both strata.ConclusionsResults show evidence that differential genetics factors, sun exposure, or other environmental or cultural factors of both strata may account for these differences.

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Section: Resultssupporting

confidence: 89%

Malignant melanoma in Chile: different site distribution between private and state patients

et al. 2014

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“…This may be attributed to the advanced disease at the time of initial diagnosis, rich vascular and lymphatic supply of mucosal sites, and the lack of clinical suspicion of these tumors because of their rarities. The prognostic factors include age, gender, anatomic site, clinical stage, and ulceration of the primary lesions (32,33).The treatment modalities rely mainly on surgical intervention, with little use of chemotherapy. The five-year survivals are below 50% in most series (34).…”

Section: Melanomas Of the Mucous Membranes (Mucosal Melanomas)mentioning

confidence: 99%

Extracutaneous Malignant Melanomas

Hussein

2008

Cancer Investigation

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Extracutaneous malignant melanomas are rare tumors with vexing clinical presentation and grim prognosis. Only 4%-5% of all primary melanomas do not arise from the skin. These tumors are almost uniformly fatal, even in 2006. Although a fairly good number of these lesions were reported in the literature, the lack of a side-by-side analysis of these studies has resulted in tentative conclusions that merely offer a first glimpse at the clinicopathologic diversity of these lesions. To remedy this issue, this article took an aim at presenting a literature review concerning extracutaneous malignant melanomas. It also reports several cases of extracutaneous melanomas, which I came across in my 15 years of surgical and molecular pathology practice. The study raises several notions. Extracutaneous malignant melanomas are rare but extremely aggressive lesions with a grim outcome. They include ocular, metastatic, anorectal, mucosal, nail beds, conjunctival, vaginal, urogenital, orbital, esophageal, and leptomeningial malignant melanomas. The development of these lesions lacks an association with sun damage, family history, or precursor nevi. These lesions cause considerable diagnostic consternation and their distinction from other types of tumors (such as undifferentiated carcinomas, high-grade sarcomas, and lymphomas) is critical both from a diagnostic and prognostic point of view. In the proper clinical, histological, and cytological context, immunopositivity for S100 protein, HMB45, and vimentin allows the distinction of these malignant melanomas from other histologically similar malignancies. To conclude, extracutaneous melanoma should be considered while undifferentiated neoplasms, especially those displaying prominent eosinophilic nucleoli, and the coexistence of epithelioid and spindle cells. Special staining and immunohistochemistry should be resorted to establish the diagnosis.

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“…Primary melanoma of the male urethra is an uncommon tumour, with fewer than 50 reported cases [1]. Overall the prognosis is poor, with conventional prognostic markers used in cutaneous melanomas being less useful at predicting survival [1,2]. Surgical excision with adequate margins is the mainstay of managing melanoma.…”

Section: Commentmentioning

confidence: 99%

Malignant melanoma of the male urethra

2002

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A 68-year-old man presented with a 3-month history of urethral bleeding. On examination a 5-mm pigmented nodule was found just inside the external urethral meatus. The remaining urethra was macroscopically normal. A biopsy confirmed malignant melanoma. There was no evidence of metastatic disease. He underwent partial amputation of the penis (Fig. 1). Histology showed a 3-mm thick melanoma with areas of Pagetoid infiltration. During the follow-up he developed an 'in-transit' recurrence in the remaining urethra at 8 months, which was treated with a total penectomy and perineal urethrostomy. At 21 months he developed inguinal nodal deposits requiring an inguinal block dissection. Despite adjuvant immunotherapy he developed systemic disease and died at 38 months. Case 2A 67-year-old man presented with a 6-month history of urethral bleeding. On examination a flat pigmented lesion was noted on the glans, with a fleshy polypoid lesion protruding from the external urethral meatus (Fig. 2).Urethroscopy showed a second flat pigmented lesion 1 cm further along the urethra. Biopsy confirmed the pigmented glans lesion to be lentigo but the polypoid lesion was malignant melanoma. A reliable Breslow thickness was not obtainable. He underwent partial penectomy, urethrectomy to encompass the second urethral lesion and a perineal urethrostomy. Histology revealed no residual tumour at the biopsy site and the proximal urethral lesion was a lentigo only. The patient remains disease-free 48 months after surgery.

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Primary Mucosal and Glans Penis Melanomas: The Sydney Melanoma Unit Experience

Cited by 37 publications

References 40 publications

Malignant melanoma in Chile: different site distribution between private and state patients

Malignant melanoma in Chile: different site distribution between private and state patients

Extracutaneous Malignant Melanomas

Malignant melanoma of the male urethra

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