Extracutaneous Malignant Melanomas

Hussein, Mahmoud R.

doi:10.1080/07357900701781762

Cited by 68 publications

(94 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association between pigmentation disorders and the nervous system has also been noted in some cases of extraepidermal melanoma tumors appearing only within the nerve sheaths and ganglia, without any pigmentation abnormalities at the skin level [126]. For instance, pigmented paragangliomas have been observed along the vagal trunk, in the adrenal gland, and in the uterus, spine, retroperitoneum, bladder, mediastinum, and orbit [127].…”

Section: Human Pathologies Potentially Associated With Schwann Cell-mmentioning

confidence: 98%

Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes

Adameyko

Lallemend

2010

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Melanocytes and Schwann cells are derived from the multipotent population of neural crest cells. Although both cell types were thought to be generated through completely distinct pathways and molecular processes, a recent study has revealed that these different cell types are intimately interconnected far beyond previously postulated limits in that they share a common post-neural crest progenitor, i.e. the Schwann cell precursor. This finding raises interesting questions about the lineage relationships of hitherto unrelated cell types such as melanocytes and Schwann cells, and may provide clinical insights into mechanisms of pigmentation disorders and for cancer involving Schwann cells and melanocytes.

show abstract

Section: Human Pathologies Potentially Associated With Schwann Cell-mmentioning

confidence: 98%

Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes

Adameyko

Lallemend

2010

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

show abstract

“…This is unusual as only 4-5% of melanomas arise from noncutaneous sites. 24 Melanoma was also the most common histology to involve the axilla and the most common metastatic lesion found in men. Owing to its wide range of morphologic appearances, it may be easily mistaken for a primary breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Non-mammary metastases to the breast and axilla: a study of 85 cases

et al. 2013

View full text Add to dashboard Cite

Non-mammary metastases to the breast and axilla are rare occurrences. However, they are important diagnostic considerations as their treatment and prognosis differ significantly from primary breast cancer. Between 1990 and 2010, we identified a total of 85 patients, 72 women and 13 men, with non-mammary malignancies involving the breast, axilla, or both. The tumor types consisted of carcinoma (58%), melanoma (22%) and sarcoma (20%). Ovary was the most common site of origin for carcinoma, and metastatic high-grade ovarian serous carcinoma was most frequently misdiagnosed as a primary breast carcinoma. Melanoma was the single most common non-carcinomatous tumor type to involve the breast and/or axilla, and uterine leiomyosarcoma was the most common type of sarcoma. Most patients (77%) had other metastases at the time of diagnosis of the tumor, but in 11% the breast or axillary lesion was the first presentation. Without a clinical history, non-mammary metastases were difficult to diagnose because the majority of cases presented with a solitary nodule and lacked pathognomonic pathologic features. There were, however, certain recurrent histological findings identified, such as the often relatively well-circumscribed growth pattern of the metastatic lesion surrounded by a fibrous pseudocapsule, and the absence of an in situ carcinoma. Overall, these patients had poor survival; 96% of patients with follow-up available are dead of disease, with a median survival of 15 months after the diagnosis of the breast or axillary lesion. This finding emphasizes the need to accurately identify these tumors as metastases in order to avoid unnecessary procedures and treatments in these patients. Keywords: axilla; breast; extramammary Metastases to the breast and axilla are rare and account for approximately 2% of all mammary malignancies. 1,2 The most common metastatic lesion to involve the breast is a metastasis from a contralateral mammary cancer. 1,2 If hematologic malignancies are also excluded, the number of non-mammary metastases drops to well below 1%. 1,3 Owing to the frequency of primary breast cancers and the rarity of non-mammary tumors involving the breast, a newly discovered lesion in the breast or axilla is usually presumed to be a primary or metastatic breast carcinoma. However, the recognition of non-mammary metastases to the breast and axilla is very important, as both the treatment and prognosis differ significantly. Materials and methodsAfter obtaining approval by our Institutional Review Board, we searched the pathology database of Memorial Sloan-Kettering Cancer Center between the years 1990-2010 for patients with non-mammary metastases to the breast and axilla. Hematologic malignancies were excluded, as they are systemic diseases. The medical records and pathology slides, when available, were reviewed and the clinicopathologic characteristics were recorded. Patient age, gender, primary tumor site, the presence of other metastases, laterality, number of lesions, interval from primary tumor diagnosis to breast/ a...

show abstract

“…25 The risk factors cited are family history, familial predisposition genes, precursor nevi, childhood sunburn, and lack of skin pigmentation. 11,25 Although melanomas are most commonly found in skin, any tissue that has melanin can be a site of tumor development.…”

mentioning

confidence: 99%

Amelanotic Melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus)

et al. 2010

View full text Add to dashboard Cite

A 3.5-year-old intact male double-transgenic New Zealand white rabbit (Oryctolagus cuniculus), apoA-I and LCAT (apolipoprotein and lecithin:cholesterol acyltransferase), was presented with a discrete, raised facial mass (0.5 Â 1.0 Â 1.0 cm). The mass was surgically excised, with reoccurrence to the same site 88 days later. A second surgical excision was performed, and the rabbit died 3 weeks later from respiratory distress. At necropsy, multiple varying-sized masses were observed in the ventral mandibular region and throughout the lungs, pleura, and diaphragm. On histopathology, the masses were composed of moderately anisocytotic and anisokaryotic polygonal to spindloid cells with moderate finely granular, lightly eosinophilic cytoplasm, having round to oval nuclei with one to several nucleoli and finely stippled chromatin. Mitotic figures were frequent. Lymphatic and venous invasion were noted with neoplastic cells metastasized to the submandibular lymph nodes, lungs, liver, and adventitial surface of the aorta. Fontana-Masson stain was negative for melanin, thereby necessitating immunohistochemistry and transmission electron microscopy. Positive staining with MART-1 (a melanocyte protein marker) combined with transmission electron microscopy revealing type II melanosomes confirmed the diagnosis of an amelanotic melanoma.

show abstract

Extracutaneous Malignant Melanomas

Cited by 68 publications

References 98 publications

Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes

Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes

Non-mammary metastases to the breast and axilla: a study of 85 cases

Amelanotic Melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus)

Contact Info

Product

Resources

About