2010
DOI: 10.1177/0300985810369898
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Amelanotic Melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus)

Abstract: A 3.5-year-old intact male double-transgenic New Zealand white rabbit (Oryctolagus cuniculus), apoA-I and LCAT (apolipoprotein and lecithin:cholesterol acyltransferase), was presented with a discrete, raised facial mass (0.5 Â 1.0 Â 1.0 cm). The mass was surgically excised, with reoccurrence to the same site 88 days later. A second surgical excision was performed, and the rabbit died 3 weeks later from respiratory distress. At necropsy, multiple varying-sized masses were observed in the ventral mandibular regi… Show more

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Cited by 9 publications
(21 citation statements)
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“…The types of skin tumors reported in rabbits ( Oryctolagus cuniculus ) include myxomatosis, fibroma, fibrosarcoma, papilloma, basal cell carcinoma, squamous cell carcinoma, sebaceous gland carcinoma, and lymphoma; melanocytic tumors are extremely rare, with only 10 cases reported to date [ 7 , 8 , 17 , 18 ]. In a previous analysis with 190 different tumors in rabbits [ 17 ], malignant melanoma accounted for only eight cases (4.2%).…”
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“…The types of skin tumors reported in rabbits ( Oryctolagus cuniculus ) include myxomatosis, fibroma, fibrosarcoma, papilloma, basal cell carcinoma, squamous cell carcinoma, sebaceous gland carcinoma, and lymphoma; melanocytic tumors are extremely rare, with only 10 cases reported to date [ 7 , 8 , 17 , 18 ]. In a previous analysis with 190 different tumors in rabbits [ 17 ], malignant melanoma accounted for only eight cases (4.2%).…”
mentioning
confidence: 99%
“…In a previous analysis with 190 different tumors in rabbits [ 17 ], malignant melanoma accounted for only eight cases (4.2%). Out of the five cases of malignant melanoma, whose outcome information (including euthanasia) were available, metastasis was confirmed in two, indicating high malignancy of these tumors [ 7 , 17 , 18 ]. However, owing to the limited number of cases reported in rabbits, a comprehensive understanding of the occurrence site, pathological characteristics, immunological phenotype, mitotic index, and proportion of Ki-67-positive cells associated with clinical outcome is lacking.…”
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confidence: 99%
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