Primary mucoepidermoid carcinoma of the breast: a with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas

Palermo, M. H. R.; Pinto, Michelli Barbara; Zanetti, Juliana da Silva; Ribeiro‐Silva, Alfredo

doi:10.5114/pjp.2013.38141

Cited by 15 publications

(5 citation statements)

References 12 publications

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“…Patients with low-grade MEC were disease free in the follow-up period, whereas high-grade MECs usually showed aggressive behavior with metastasis to axillary nodes and distant organs [17]. Immunohistochemically, MUC5AC is expressed in more than 50% of high-grade tumors and MUC1 expression correlates with shorter disease-free survival [18]. …”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma

Fujino¹,

Mori²,

Akashi³

et al. 2016

Case Rep Oncol

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A 71-year-old woman, previously treated for malignant lymphoma, was admitted to our hospital with a tumor in the right breast. The tumor size was 2.0 cm in diameter, and the borderline was unclear. The core needle biopsy material revealed an invasive adenocarcinoma with metaplastic change. Right mastectomy and sentinel lymph node biopsy was performed. Histologically, the tumor was composed of mucus-secreting, epidermoid, and intermediate cells. These findings confirmed the diagnosis as mucoepidermoid carcinoma (MEC) of the breast. MEC is more frequently observed in the salivary glands and occurs rarely in the breast, with an incidence of approximately 0.3% of all breast cancers. Because of the rarity of the disease, the clinicopathological features and clinical outcome have not been fully investigated. The relationship between MEC of the breast and lymphoma are unclear. Here we report a rare case of MEC of the breast.

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Section: Discussionmentioning

confidence: 99%

Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma

Fujino¹,

Mori²,

Akashi³

et al. 2016

Case Rep Oncol

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“…Histological classification is determined according to the ratio of cystic components, the presence of neural invasion and necrosis, the mitotic ratio, nuclear grade, border/invasive front, lymphovascular, and bone invasion (Table 2). [16,34] Given their significantly overlapping histomorphologic characteristics, the differential diagnosis of MEC broadly includes intraductal papilloma, clear cell hidradenoma, and adenomyoepithelioma.…”

Section: Discussionmentioning

confidence: 99%

A high-grade breast mucoepidermoid carcinoma without MAML2 rearrangement: A case report and literature review

Wang,

Cheng,

Wang

et al. 2024

Medicine

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Introduction: Mucoepidermoid carcinoma (MEC) of the breast is an extremely rare primary breast tumor. Between 1979 and June 2022, only 50 cases were reported. The pathological morphology and biological behavior of breast MEC remain poorly understood. Patient concerns: A 47-year-old female was presented with a 10-day-old left breast mass detected by physical examination. Diagnoses: Ultrasonography could not distinguish whether the breast tumor was benign or malignant. After a biopsy of a breast tumor excision specimen, combined with immunohistochemical results, the patient was diagnosed with high-grade mucoepidermoid breast carcinoma. Interventions: The patient underwent a modified radical mastectomy for her left breast. Outcomes: The patient was still free from local recurrence or metastases at 1-year follow-up. Conclusion: A high-grade MEC case without MAML2 rearrangement shows good recovery without complications. The diagnosis was confirmed by histomorphology and immunohistochemical markers. It is sometimes necessary to distinguish it from adenosquamous, adenoid cystic, or mucinous carcinoma. The primary treatment is surgical resection, and the prognosis is closely related to the pathological grade.

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“…Sherwell-Cabello et al [14] 2017 86 6.0 NS LG 0/NS NO 3 Alive NS 9 Cheng et al [15] 2017 Fujino et al [16] 2016 71 1.7 NS IG 0/NS NO NS NS NO 14 Palermo et al [17] 2013 80 4.0 NS HG 0/NS NO NS NS NS 15 Turk et al [18] 2013 40 5.5 CH NS 1/24 NO 5 Alive NS 16 Basbug et al [19] 2011 Di Tommaso et al [23] 2004 80 0. hormone-dependent, and endocrine therapy may an option. Nakano et al [36] reported that patients with MAML2 gene rearrangement were better prognosis.…”

Section: Breast Mec In Clinical Treatment and Prognosismentioning

confidence: 99%

Mucoepidermoid carcinoma of the breast, 3 cases report and literature review

He¹,

You

Chen³

et al. 2023

Medicine

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Rationale: Mucoepidermoid carcinoma (MEC) is one of the most common malignant tumors in salivary glands, with specific histomorphological and molecular characteristics. MEC occurring in breast is more rare. Patient concerns: We reported 3 cases of female breast mass, diagnosed as benign nodules by ultrasound. Diagnoses: The first 2 cases were pathological diagnosed as breast MEC, low grade, and the third case as breast MEC, medium grade. Interventions: After pathological diagnosis, 3 patients have expanded the scope of breast resection and lymph node dissection, with negative margin and no lymph node metastasis. Outcomes: In the follow-up observation, the first case was followed up for 24 months, the second case was followed up for 30 months, and the third case was followed up for 12 months. All patients had a good prognosis without evidence of recurrence and metastasis. Conclusion: Breast MEC is extremely rare and estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 negative breast cancer with a good prognosis, which is different from other highly malignant triple-negative breast cancers. reviewed its clinicopathologic morphological characteristics, immunohistochemical markers and molecular characteristics, prognosis and clinical treatment through literature, in order to understanding its clinicopathology and providing reference for clinical precise treatment.

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Primary mucoepidermoid carcinoma of the breast: a with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas

Cited by 15 publications

References 12 publications

Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma

Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma

A high-grade breast mucoepidermoid carcinoma without MAML2 rearrangement: A case report and literature review

Mucoepidermoid carcinoma of the breast, 3 cases report and literature review

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