Primary Mucinous Sweat Gland Carcinoma of the Eyelid Simulating Metastatic Carcinoma

Fu, Yao; Levine, Mark R.

doi:10.1016/0002-9394(79)90188-0

Cited by 48 publications

(25 citation statements)

References 6 publications

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“…Thereafter, similar cases of PCSRCC have been reported, exclusively involving the eyelids. [17][18][19] Recently, a few cases involving the axilla have been reported. 20,21 None of the reported cases had any detectable primary internal malignancies.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

Kiyohara

Kumakiri

Kouraba

et al. 2006

Journal of the American Academy of Dermatology

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Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocarcinomas. It is defined as a diffuse malignant epithelial neoplasia localized in the dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of visceral adenocarcinoma. We present 2 cases of PCSRCC, which involved eyelids and axilla respectively. Despite thorough systemic workup, primary sources could not be demonstrated in either case. The tumor cells are positive for gross cystic disease fluid protein 15 in addition to a variety of glandular markers. Furthermore, both cases were immunostained with cytokeratin 20 (CK20). In conclusion, we report 2 cases of PCSRCC expressing CK20 immunoreactivity. CK20-positive primary cutaneous tumors should include PCSRCC in addition to Merkel cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

Kiyohara

Kumakiri

Kouraba

et al. 2006

Journal of the American Academy of Dermatology

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“…13,14 From an evolutionary perspective, 2 different scenarios have been proposed for the evolution of the apocrine sweat glands; 15 the first scenario is that apocrine sweat glands primarily function in reproduction and sexual behavior, and the second scenario is that they are primarily a defense against microorganisms. Indeed, 2 different phenotypes of apocrine sweat glands corresponding to these 2 proposed functions exist.…”

Section: 25mentioning

confidence: 99%

A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Iwaya

Uehara

Yoshizawa

et al. 2012

The American Journal of Dermatopathology

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Disclosure: There are no conflicts of interest to declare. AbstractPrimary signet-ring cell/histiocytoid carcinomas of the eyelid are extremely rare tumors considered to originate from sweat glands. Here, we report the case of a 72-year-old man diagnosed with primary signet-ring cell/histiocytoid carcinoma of the eyelid and present immunohistochemical analyses of the eyelid apocrine gland (Moll gland) and apocrine and eccrine sweat glands of perineum and axilla. Widespread infiltration of tumor cells with signet-ring cell or histiocytoid appearance was observed in his left eyelid, orbit, and periocular lesion.

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“…In earlier reports, the neoplasm was thought to originate from eccrine sweat glands. Rosen et al [51] and Thomas et al [19] conducted ultrastructural studies and found both clear and dark cells and intracytoplasmic lumina with villi, which favored an eccrine origin. More recent reports have favored apocrine differentiation because the tumor has Periodic Acid-Schiff-positive diastase-resistant secretions and positive immunostaining for the apocrine marker GCDFP-15 [1].…”

Section: Discussionmentioning

confidence: 99%

“…HER2neu overexpression was negative in all 6 reported cases [1,3,5,39]. In comparison, immunoreactivity for ER, PR, and HER2neu in 29 cases of histiocytoid breast carcinoma was 44,19, and 57%, respectively [21,22,26,29,[31][32][33][34][43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

“…Metastases have occurred in around half of the reported cases, usually to nearby lymph nodes [2,12]. Tumor-related deaths have also been described [6,13,18,19]. The periorbital lesions often present as diffuse swelling and thickening of the involved lid, with normal or erythematous skin, and tend to infiltrate circumferentially around the eyelid, leading to their "monocle-like" appearance [20].…”

Section: Introductionmentioning

confidence: 99%

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Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

et al. 2018

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Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.

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Primary Mucinous Sweat Gland Carcinoma of the Eyelid Simulating Metastatic Carcinoma

Cited by 48 publications

References 6 publications

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

A Case of Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

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