Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity

In recent years, there has been significant progress in immunohistochemistry as an ancillary tool in diagnostic dermatopathology. In most instances, the histologic diagnosis can be rendered with the routine histologic sections; however, immunohistochemistry can help to narrow the differential in diagnosing neoplasms of cutaneous appendages in some settings including adnexal versus epidermal origin, benign versus malignant adnexal neoplasms, and primary adnexal carcinoma versus cutaneous metastases as outlined in this review.

Section: Primary Adnexal Carcinoma Versus Cutaneous Metastasesmentioning

confidence: 99%

Role of Immunohistochemistry in Diagnosing Tumors of Cutaneous Appendages

Hoang

2011

“…The patients usually present with an indurate lesion on 1 eyelid especially the lower eyelid, most of which subsequently develop involvement of the other eyelid of the same affected side, causing a "monocle-like" 16 appearance. Involvement of upper and lower eyelids at the initial presentation is noticed in 9 patients 3,8,10,11,[15][16][17] including this case. There is minimal left to right side predilection (1.2:1).…”

Section: Discussionmentioning

confidence: 65%

Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Tanboon¹,

Uiprasertkul²,

Luemsamran

2013

Signet-ring cell/histiocytoid carcinomas of the eyelid are rare, slow-growing, and locally aggressive tumors. They predominantly affect elderly men and clinically resemble chronic inflammatory process such as blepharitis and chalazion. To date, the histogenesis of the tumors is still controversial. Only 27 cases of primary signet-ring cell/histiocytoid carcinomas of the eyelid are published in the literature. Local recurrence and distant metastasis occur in 8 and 7 cases, respectively. We report clinical, radiographic, and pathological features of a case of signet-ring cell/histiocytoid carcinoma of the eyelid with review of relevant literature.

“…Primary cutaneous signet ring cell carcinoma shows intracytoplasmic mucin vacuoles and expresses cytokeratins CAM5.2 and AE1-3, cytokeratin 7, epithelial membrane antigen (EMA), CEA, p63, mucin-1, 16,17 and cytokeratin 20. 18 Cutaneous metastases from signet ring cell carcinoma may be the initial presentation of a gastric or colorectal carcinoma. In both cases, there are intracytoplasmic mucin vacuoles.…”

Section: Discussionmentioning

confidence: 99%

“…7 In the cutaneous signet ring cell adenocarcinoma, either primary or metastatic, intracytoplasmic vacuoles containing mucin are positive with PAS, PAS-digest, and colloidal iron. 7,[16][17][18] The tumor cells express cytokeratin, and most vacuoles express CEA while vimentin is negative. 7 In the case of signet ring cell melanoma, either primary or metastatic, intracytoplasmic vacuoles are negative with PAS, colloidal iron, cytokeratin, and CEA.…”

Section: Discussionmentioning

confidence: 99%

“…6,10,15 In summary, we emphasize the importance of S-100 and melan A immunostaining of signet ring melanocytes, especially the S-100 nuclear staining pattern, to recognize this particular variant of melanocytic nevus. [6][7][8][9][10][11][12][13][14][15] PAS2, mucicarmine2/S100+, melan A+, Vimentin+, HMB-456 Primary signet ring cell carcinoma [16][17][18] PAS+, PAS-digest+, alcian blue+, mucicarmine+/CKCAM5.2+, CKAE1/3+, CK7+, CK34bE12+, EMA+, CEA+, p63+, MUC-1+, CK206, GCDFP15+ Metastatic signet ring cell gastric or colorectal carcinoma 19,20 PAS+, mucicarmine+/CKAE1/3+, CK20+, CK18+, GCDFP152, CK72, synaptophysin2, p632 Signet ring T-cell lymphoma 21 LCA2, CD3+, CD5+, CD8+ Signet ring B-cell lymphoma 22 LCA2, CD20+, CD10+, kappa/lambda light chain restriction Signet ring squamous cell carcinoma 23 CKAE1/3+, CK34bE12+, p63+, EMA+ Signet ring cell basal cell carcinoma 24 CKAE1/3+, CKCAM 5.2+, SMA+, EMA+, GFAP+ Histiocytoid hemangiomas, angiosarcomas, or epithelioid angiomatous neoplasms [25][26][27] PAS+ (no mucin)/Factor VIII+, CD34+…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Signet Ring Cell Melanocytic Nevus: Report of a Case Over Trichilemmal Cyst and Review of the Literature

Marco¹,

Muñoz²,

Faet³

et al. 2012

Different melanocytic nevi have been reported as being associated with dermal cysts. Signet ring cell melanocytic nevus is a rare variant of melanocytic nevus characterized by cells with signet ring morphology within a common melanocytic nevus. This article describes an exceptional case of melanocytic nevus composed exclusively of signet ring cells over a trichilemmal cyst. Histologically, above the cyst, there was a small, symmetrical and sharply demarcated lesion showing a compound proliferation of small, round, monomorphous cells with signet ring morphology. Immunohistochemically, signet ring cells were negative for cytokeratin AE1/3, leukocyte common antigen, HMB-45, and CD34. Occasionally, isolated signet ring cells were positive for S-100 and melan A. Melanocytic nevus composed of signet ring cells should raise the differential diagnosis with other cutaneous tumors exhibiting signet ring cells. Previous cases of this entity reported in the literature are also reviewed.