Primary mucinous adenocarcinoma of the female urethra: a contemporary clinicopathologic analysis

Harari, Saul; Liu, Cheng; Osunkoya, Adeboye O.

doi:10.1016/j.humpath.2015.09.014

Cited by 21 publications

(19 citation statements)

References 17 publications

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“…The tPSA value of these patients has never increased. Tumors are generally positive for CEA, CK7, and CK20 and negative for PSA and PSAP ( 38 ). It is worthwhile noting that mucinous carcinoma with signet-ring cells and signet-ring cell carcinoma also have mucinous features, making it particularly essential to distinguish these from mucinous adenocarcinoma, since these tumors are extremely aggressive, with no response to endocrine therapy, and there is zero rate of survival for 5-year patients ( 11 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Prostate Adenocarcinoma With Mucinous Features of Normal-Level Serum PSA, Atypical Imaging, Biopsy-Negative, and Peculiar Urethrocystoscopic Manifestation

et al. 2020

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BackgroundMucinous tumors of the prostate are seen as rare morphological variants of prostate carcinoma. Misdiagnosis and missed diagnosis are frequent clinically, especially when the clinical performance appears atypical. Furthermore, there has not been reported about the urethrocystoscopic performance of mucinous adenocarcinoma growing into the prostatic urethra so far.Case PresentationThe current case report describes a 48-year old Asian male who was hospitalized because of intermittent gross hematuria for more than two months. The patient was diagnosed as prostatic space occupying lesions and an examination of needle biopsy was conducted on him, which did not indicate a definite malignancy. Transurethral plasma kinetic resection of the prostate (TUPKP) was performed for the patient, but the postoperative pathology revealed prostatic adenocarcinoma with mucinous features. Specifically, two cord-like neoplasms, extending to the bladder neck, were found through urethrocystoscopy in the prostatic urethra, both of which grew pedicles. The pedicles were situated on the right side of the parenchyma of the prostate. Finally, the patient underwent radical prostatectomy three weeks later.ConclusionHere, we reported a case that prostatic adenocarcinoma with mucinous features was diagnosed after TUPKP. The patient had normal serum prostate-specific antigen levels with atypical images and negative biopsy result. This report lays stress on the vigilance of clinicians in prostate mucinous adenocarcinoma and makes a description of its peculiar urethrocystoscopic manifestation, typical imaging, and unique growth pattern for the first time.

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Section: Discussionmentioning

confidence: 99%

Case Report: Prostate Adenocarcinoma With Mucinous Features of Normal-Level Serum PSA, Atypical Imaging, Biopsy-Negative, and Peculiar Urethrocystoscopic Manifestation

et al. 2020

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“…In the presence of chronic urethritis, the glandular epithelium may develop an adenocarcinoma with intestinal metaplasia. 5 Skene's gland adenocarcinoma, on the other hand, is extremely rare, accounting for less than 0.003% of all female urethral malignant neoplasms. 1 To the best of our knowledge, only six cases of female urethral adenocarcinomas with any evidence of a Skene's gland origin have been reported.…”

Section: Discussionmentioning

confidence: 99%

Skene's gland adenocarcinoma with intestinal differentiation: A case report and literature review

Muto

Inamura

Ozawa

et al. 2017

Pathology International

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Adenocarcinoma of Skene's gland (the female homolog to the male prostate) is extremely rare, with only a few cases reported. We present a case of Skene's gland adenocarcinoma with intestinal differentiation. The patient was a 69-year-old Japanese woman who was operated on for a recurrent tumor of the external ostium of the urethra. Histopathologically, the tumor showed glandular and cribriform patterns with a signet-ring cell component in a mucus lake. Immunohistochemically, the tumor cells were positive for prostate specific acid phosphatase (PSAP), and AMACR, and negative for Nkx3.1 or prostate specific antigen (PSA). Although in situ lesion could not be discovered, positive immunostainings for Nkx3.1, PSAP, and androgen receptor in the remaining paraurethral glands around the tumor indirectly but strongly suggest that the tumor had originated from Skene's gland. This tumor also showed intestinal differentiation as suggested histologically and by positive immunostainings for CDX2, MUC2, and CK20, along with negative immunostaining for CK7. It is often very difficult to identify the origin of a female urethral carcinoma. In such cases, immunohistochemical features can be an essential clue to the origin. We therefore present this instructive case with a literature review.

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“…Insgesamt sind die Fallzahlen der vorliegenden Arbeiten relativ niedrig, sodass primär auf die relevanten Ätiologien eingegangen wird. Hinsichtlich weiterer Erkrankungen, die im Verlauf zur pathognomonischen Harnröhrenstriktur führen können werden die Urogenitaltuberkulose [18], Lichen sclerosus [19], Harnröhrenkarzinome [20,21] oder Harnröhrenpolypen [22] genannt.…”

Section: äTiologie Und Pathophysiologie Der Weiblichen Harnröhrenerkrankungenunclassified

Harnröhrenstrikturen der Frau: Aktuelles zu Diagnostik und Therapie

2021

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ZusammenfassungHarnröhrenstrikturen der Frau sind ein seltenes Krankheitsbild mit individueller Symptomatik. Vor diesem Hintergrund mangelt es an klinischen Leitfäden, die sich mit Diagnostik und Therapie dieser Erkrankung befassen. Mittlerweile liegen einige Ergebnisse zu verschiedenen Operationstechniken vor, ein direkter inter-institutioneller Vergleich wird jedoch durch heterogene Patientenkohorten und kleine Fallzahlen erschwert. Die vorliegende Arbeit befasst sich mit einer aktuellen narrativen Literaturübersicht relevanter Artikel zur klinischen Diagnostik und zu den Therapiemöglichkeiten bei weiblicher Harnröhrenstriktur.Iatrogene Ursachen wie eine vorangegangene Katheterisierung oder ein urogenitaler operativer Eingriff sind die häufigsten Gründe für die Entstehung einer Harnröhrenstriktur bei der Frau. Im klinischen Alltag stellt die körperliche Untersuchung einen wichtigen Grundstein in der Differentialdiagnostik dar, um bei Verdacht auf eine anatomisch-morphologische Ursache der Harnblasenentleerungsstörung weitere diagnostische Maßnahmen (Urethrozystoskopie, Urethrographie, MRT) einzuleiten. Therapeutisch sind minimal-invasive Eingriffe wie Harnröhrenbougierungen oder Urethrotomien oftmals nur mit kurzfristigem Erfolg assoziiert, sodass die offene Harnröhrenrekonstruktion mit langfristigeren Therapieerfolgen hier eine Sonderstellung einnimmt. Zur Verfügung stehen neben offenen Harnröhrenplastiken mit gestielten Lappen aus Vaginal- oder Labialschleimhaut auch die Verwendung freier Transplantate, vor allem dem Mundschleimhaut-Autotransplantat. Aufgrund der genannten Seltenheit der Erkrankung mit nur kleinen publizierten Fallserien ist jedoch eine Beurteilung der vergleichenden Wirksamkeit der verschiedenen Techniken nur schwer möglich. Wie bei allen seltenen Erkrankungen bedarf es hier der Etablierung von multizentrischen, großen Serien, um die Standards im perioperativen Vorgehen zu verbessern.

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Primary mucinous adenocarcinoma of the female urethra: a contemporary clinicopathologic analysis

Cited by 21 publications

References 17 publications

Case Report: Prostate Adenocarcinoma With Mucinous Features of Normal-Level Serum PSA, Atypical Imaging, Biopsy-Negative, and Peculiar Urethrocystoscopic Manifestation

Case Report: Prostate Adenocarcinoma With Mucinous Features of Normal-Level Serum PSA, Atypical Imaging, Biopsy-Negative, and Peculiar Urethrocystoscopic Manifestation

Skene's gland adenocarcinoma with intestinal differentiation: A case report and literature review

Harnröhrenstrikturen der Frau: Aktuelles zu Diagnostik und Therapie

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