Primary motor cortex deactivation as a new mechanism of motor inhibition in conversion paralysis

Matt, Eva; Amini, Ahmad; Aslan, Tuna Stefan; Schmidhammer, Robert; Beisteiner, Roland

doi:10.1002/mds.27552

Cited by 4 publications

(1 citation statement)

References 7 publications

(9 reference statements)

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“…Within the last years, diagnostic fMRI research detected several important networks that may be clinically targeted to improve patients' deficits, for example, the memory network, language network or motor network. [36] Recent animal data have shown that these can be independently modulated by transcranial ultrasound and modulations cannot be explained by pure acoustic stimulation effects. [37,38] Ultrasound brain stimulation is typically performed with single channel systems equipped with neuronavigation for individualized targeting of the patient's brain.…”

Section: Brain Stimulation Therapymentioning

confidence: 99%

Transcranial Ultrasound Innovations Ready for Broad Clinical Application

Beisteiner

Lozano

2020

Advanced Science

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Brain diseases are one of the most important problems in our rapidly ageing society. Currently, there are not many effective medications and surgical options are limited due to invasiveness and non-invasive brain stimulation techniques cannot be well targeted and cannot access deep brain areas. A novel therapy is transcranial ultrasound which allows a variety of treatments without opening of the skull. Recent technological developments generated three revolutionary options including 1) targeted non-invasive surgery, 2) highly targeted drug, antibody, or gene therapy via local opening of the blood-brain barrier, and 3) highly targeted brain stimulation to improve pathological brain functions. This progress report summarizes the current state of the art for clinical application and the results of recent patient investigations.

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Section: Brain Stimulation Therapymentioning

confidence: 99%