Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9-Year-Old Patient

Bravo‐Balado, Alejandra; Castellanos, Lynda Torres; Rodriguez, A; Zapata, Daniel Gómez; Hoyos, Juan Javier Lammoglia; Andrade, Rafael; Niño, Jaime Pérez

doi:10.1016/j.urology.2017.08.038

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…Malignant germ-cell tumours account for 2.9% of all malignant childhood tumours, in patients younger than 15 years old. Tissues that are affected, other than the ovaries include the CNS, the coccyx, the testes, retroperitoneum, and mediastinum (15,16). These tumours, especially of ovarian origin, can produce β--fore, to a substantial increase in intracellular cAMP, which, in turn, enhances the production and secretion of hormones in affected tissues.…”

Section: Ovarian Tumours and Cystsmentioning

confidence: 99%

Pathophysiology of Peripheral Precocious Puberty in girls: an overview

Toutoudaki

Paltoglou

Paschalidou

et al. 2021

DAH

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Precocious puberty can be distinguished in central, or peripheral, based on the presence or absence of the Hypothalamic- Pituitary- Gonadal axis activation. The pathogenesis of peripheral precocious puberty (PPP) is based mainly on excessive estrogenic exposure, either endogenous or exogenous. The congenital causes of PPP include McCune- Albright syndrome (MAS) and Congenital Adrenal Hyperplasia (CAH). The main causes of acquired PPP are oestrogen producing tumours, which are mainly of ovarian or adrenal origin, hypothyroidism and environmental oestrogens or substances with estrogenic function.

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Section: Ovarian Tumours and Cystsmentioning

confidence: 99%

Pathophysiology of Peripheral Precocious Puberty in girls: an overview

Toutoudaki

Paltoglou

Paschalidou

et al. 2021

DAH

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“…Patients may present with non-specific symptoms, or with symptoms related to mass effect: respiratory symptoms such as cough and breathlessness due to compression of the trachea, chest pain, or superior vena cava syndrome and heart failure ( 15 - 17 ). Occasionally, patients may present with clinical features due to hormone production by a functional tumor, such as precocious puberty ( 18 ).…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

Pediatric mediastinal germ cell tumors

Kakkar¹,

Kaur²,

Verma³

2019

Mediastinum

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Mediastinal germ cell tumors (GCTs) are a rare and heterogeneous group of neoplasms. Although histologically resembling their gonadal counterparts, they differ considerably in their clinical characteristics, biological behavior and prognostic outcome. The rarity of mediastinal GCTs has hindered their meaningful analysis, with most studies and clinical trials including them along with other extragonadal GCTs, which has led to a lack of consensus on optimal treatment strategies, and a lull in improvement in patient outcomes. Diagnosis of mediastinal GCT requires a multipronged approach, and encompasses multidisciplinary treatment including chemotherapy followed by surgery, with or without radiotherapy. In view of sustained response rates to current management protocols, the focus needs to be shifted to identifying patients in whom treatment regimens can be downscaled with the aim of decreasing long term morbidity and improving quality of life in low risk patient groups, while improving survival rates in poor risk patient subsets. In this scenario, better understanding of the molecular pathogenesis of these tumors may lead to identification of novel biomarkers and therapeutic targets, as well as improved disease segmentation and risk stratification, thus helping to avoid the toxicity and morbidity associated with current one-fits-all treatment strategies. Multi-institutional collaborations across continents are necessary to generate meaningful data, and are the face of future developments in this arena.

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Gonadotrophin-Independent Precocious Puberty; Female and Male

Drop¹,

Grinten²

2019

Encyclopedia of Endocrine Diseases

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Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9-Year-Old Patient

Cited by 5 publications

References 14 publications

Pathophysiology of Peripheral Precocious Puberty in girls: an overview

Pathophysiology of Peripheral Precocious Puberty in girls: an overview

Pediatric mediastinal germ cell tumors

Gonadotrophin-Independent Precocious Puberty; Female and Male

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