Fibroadenomas are common benign breast tumors. Fibroadenomas that exceed 5 cm in diameter, weigh more than 500 g, or replace more than four-fifths of the breast are characterized as giant. A fibroadenoma diagnosed in patients during childhood or adolescence is characterized as juvenile. An extensive PubMed search of the literature in English up until August 2022 was performed. In addition, a rare case of a gigantic fibroadenoma in an 11-year-old premenarchal girl who was referred to our adolescent gynecology center is presented here. Eighty-seven cases of giant juvenile fibroadenomas have been reported in the literature along with our case. Patients with giant juvenile fibroadenoma presented at a mean age of 13.92 years and usually after menarche. Juvenile fibroadenomas are usually unilateral, occurring either in the right or the left breast; the majority of them are diagnosed when they are already more than 10 cm in size, and they are most frequently treated with total lump excision. Differential diagnosis includes phyllodes tumors and pseudo-angiomatous stromal hyperplasia. Conservative management is feasible, but surgical excision is recommended to patients with suspicious imaging features or when the mass grows rapidly.

Background: The COVID-19 pandemic changed everyday life dramatically. Lockdowns, imposed to prevent viral transmission have been investigated as possible contributors to negative health outcomes for all ages, as well as disruptors of normal children’s development. In this setting, an increase in consults for precocious puberty has been observed. Aim: To investigate the possible effects of the pandemic and lockdowns on the timing of puberty, along with the mechanisms interfering with pubertal onset. Methods: The study was conducted, according to the PRISMA guidelines, using the Advanced Search tools of the PubMed platform. Only the articles that were considered relevant were included. Results: Multiple reports for an increased incidence of precocious puberty have been published, comparing data with the pre-lockdown era, and attempting to shed light into the possible causes of this trend. Conclusions: The most popular factors that could have an influence in pubertal timing were BMI increase, overuse of electronic devices and psychological stress.

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