Primary mandibular bone xanthoma

Mateo, Mariano Marqués; Torres, M. Puche; Alba, L. Miragall; Gimilio, M.E. Iglesias; Gil, J.

doi:10.1016/j.ijom.2003.12.006

Cited by 31 publications

(27 citation statements)

References 4 publications

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“…After the elimination of 192 duplicates, the parameters for inclusion and exclusion were applied to 442 references. A total of 16 articles reporting 31 cases of IOX of the jaws were selected . The studies included in the present literature review were case reports or case series.…”

Section: Resultsmentioning

confidence: 99%

“…The studies included in the present literature review were case reports or case series. The articles were from the US, Canada, Brazil, Sweden, the Netherlands, Spain, the UK, Japan and Australia …”

Section: Resultsmentioning

confidence: 99%

“…Thus far, few cases of IOX of the jaws with enough clinicopathologic and radiographic details to confirm the diagnosis have been documented in the literature . Since case series of IOX of the jaws are infrequent in the literature, in order to provide consistent and well‐documented reports that may serve as a basis for a better understanding of the lesion, we describe here a series of five new cases of IOX of the mandible in a multi‐institutional study, with emphasis on clinicopathological, radiographic and immunohistochemical data of this condition as compared with reports detected in a literature review.…”

Section: Introductionmentioning

confidence: 92%

“…This condition typically occurs in endocrine or metabolic diseases with increased cholesterol levels, in particular primary hyperlipidaemia, hypolipoproteinaemia type II and III, diabetes mellitus, hypothyroidism and lipoprotein lipase deficiency, and therefore, it is called secondary bone xanthoma . In the absence of systemic diseases, the lesion is called primary xanthoma …”

Section: Introductionmentioning

confidence: 99%

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Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Arruda

Almeida

Abreu

et al. 2019

J Oral Pathology Medicine

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Background The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review. Methods Clinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S‐100. Results The series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13‐45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched‐out margin (80%). All cases predominantly consisted of CD68‐positive and S‐100‐negative xanthomatous cells. No recurrences were observed after curettage, with a median follow‐up of 27 months. Conclusion Intraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Arruda

Almeida

Abreu

et al. 2019

J Oral Pathology Medicine

View full text Add to dashboard Cite

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“…The most frequent location of bone xanthoma is the diaphysis of long bones, especially the tibia. Other locations may be particularly in the facial skeleton, mastoid air cells [5–7], and mandibular bone [8]. The skull can be affected (temporal [5–7] or frontal [9]) which may cause cerebellar compression.…”

Section: Discussionmentioning

confidence: 99%

Xanthoma of Bone: A Case Report

Guerrouj

Mouaden

BenRais

2012

Case Reports in Endocrinology

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Bone xanthoma is a rare disease due to the presence of cholesterol deposits in the bone. We report a case of a 56-year-old patient who was hospitalized in orthopedic department for fracture on the left humerus. Histological examination of bone biopsy performed at this site has objectified cholesterol deposits. Laboratory tests showed hypercholesterolemia with hypertriglyceridemia. The diagnosis of bone xanthoma was selected. The fracture was treated surgically. An initial bone scan revealed bone lesions localized especially at the humerus and femur. The patient was put under fenofibrate and statins. The evolution was marked by gradual regression of lesions in bone scans of control.

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Primary Xanthoma of the Mandible: Report of a Rare Case

Morel

Kelsch

Nolan

2015

Head and Neck Pathol

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Xanthoma is a lesion most commonly seen in soft tissues such as the skin, subcutis, or tendon sheaths. Xanthoma formation is often associated with primary or secondary hyperlipidemia. Primary bone xanthomas are extremely rare benign bone lesions not associated with hyperlipidemia, histopathologically characterized by histiocytes, abundant lipid containing macrophages (foam cells), and multinucleated giant cells. Cholesterol clefts can be found in the medullary bone. Less than ten cases of xanthoma in the mandible have been reported. We present a rare primary intrabony xanthoma in a normolipidemic patient.

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Primary mandibular bone xanthoma

Cited by 31 publications

References 4 publications

Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Xanthoma of Bone: A Case Report

Primary Xanthoma of the Mandible: Report of a Rare Case

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