Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Kühn, Florian; Dieterich, M.; Klar, E.; Gerber, Bernd; Prinz, Carsten

doi:10.1055/s-0032-1315006

Cited by 11 publications

(10 citation statements)

References 14 publications

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“…The histopathological findings in our patient are largely consistent with what has been reported in the literature as features commonly observed in primary melanoma of the vagina, namely, and in no particular order: an epithelioid morphology (which is the most common morphology, reported in more than half of the cases)9; an in situ component with an overlaying intact epithelium; cytological atypia and mitotic activity 13–15. Various markers of immunohistochemical staining have traditionally also been used to provide reliable confirmation of a diagnosis of primary vaginal melanoma, including protein S-100, T311, Mart-1, Melan A, HMB-45, tyrosinase and vimentin 5 7.…”

Section: Discussionsupporting

confidence: 89%

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Primary malignant melanoma of the vagina

2020

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Primary malignant melanoma of the vagina is a rare gynaecological neoplasm with an aggressive course of disease. Although not many cases have been reported in the literature, its manifestations appear to be fairly consistent. The challenge comes in knowing how to approach this cancer clinically, since information about its staging and treatment is limited. In this report, we present a case of an 84-year-old postmenopausal woman in whom a suspicious vaginal lesion was discovered incidentally during a procedure. Wide local excision was carried out at a later date and histopathology confirmed a malignant melanoma of the vagina contained locally with no radiological finding of distant metastases. No additional treatment was given, and three monthly follow-ups were arranged for this patient. We review the literature and briefly discuss the epidemiology, treatment approaches, prognostic factors and expected outcomes of this rare disease.

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Section: Discussionsupporting

confidence: 89%

“…Lymph node involvement, if any, significantly worsened the prognosis of patients 2 29. The reported rate of lymph node involvement or metastases ranges quite widely from as low as 8% to as high as 50% 3 14. Overall, the expected outcome of patients with primary malignant vaginal melanoma is poor.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the vagina

2020

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“…The common sites of metastases are lungs, liver, bones, and brain. Tumor size is the most important prognostic factor [3][4][5]. The overall five-year survival rate for women with vaginal melanoma is only about 8-20% when compared to around 47% for women with melanoma of the vulva and 81% for women with cutaneous melanoma [2,6].…”

Section: Discussionmentioning

confidence: 99%

Primary Vaginal Malignant Melanoma: A Case Report and Review of Literature

Paravathaneni

Keshava

Baralo

et al. 2020

Cureus

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Primary vaginal malignant melanoma is an extremely rare and aggressive tumor with very few reported cases worldwide. It often occurs in post-menopausal women, with a mean age of 57 years. The most common presenting symptom is vaginal bleeding. Other less common presenting symptoms are vaginal discharge, vaginal mass, and pain. Vaginal melanomas are often diagnosed at an advanced stage, and despite the aggressive treatment approach, the prognosis is poor. We present to you a case of a 56-year-old postmenopausal woman who presented with intermittent vaginal bleeding and passage of dark clots. She was found to have symptomatic anemia requiring blood transfusions. Further workup revealed a mass in the upper vagina on imaging studies, and the patient eventually underwent a biopsy, which confirmed the diagnosis of malignant melanoma of the vagina on pathological examination.

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“…Primary vaginal malignant melanomas are rare and aggressive tumors. Only 500 cases have been reported [ 2 ], principally affecting postmenopausal women, with a mean age of 57 years [ 4 ]. Mucosal melanomas are more often associated with KIT gene mutations rather than BRAF mutations, which are more often found in cutaneous melanomas [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma

Garg

Gupta

2018

Obstet Gynecol Sci

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We report a rare case of vaginal amelanotic melanoma. Malignant melanomas are cutaneous and extracutaneous tumors that arise from embryological remnants of neural crest cells/melanocytes. Amelanotic melanomas at such rare locations can be misdiagnosed both clinically and radiologically. Therefore, histopathological examination and immunohistochemistry are mandatory for the diagnosis of these tumors. We diagnosed this case using histopathology and confirmed the diagnosis based on the presence of immunohistochemical markers human melanoma black 45 (HMB45) and S-100.

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Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Cited by 11 publications

References 14 publications

Primary malignant melanoma of the vagina

Primary malignant melanoma of the vagina

Primary Vaginal Malignant Melanoma: A Case Report and Review of Literature

Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma

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