Primary malignant solid pseudopapillary tumors of the gastroduodenal area

Walter, Thomas; Hommell-Fontaine, Juliette; Hervieu, Valérie; Adham, Mustapha; Poncet, Gilles; Dumortier, Jérôme; Lombard‐Bohas, Catherine; Scoazec, Jean‐Yves

doi:10.1016/j.clinre.2011.01.004

Cited by 19 publications

(14 citation statements)

References 25 publications

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“…In terms of prognosis of extrapancreatic SPTs, like pancreas SPT, most of the tumors showed good prognosis after surgical resection as a primary treatment regardless of tumor recurrence or metastasis ( 1 3 4 5 6 7 8 9 10 11 ). On the basis of previous literatures reviews, four cases (20%) showed metastasis or tumor recurrence and half of them showed more than eight years survival period by repeating treatments for recurrence ( 1 7 ). Although there is limitation due to small patient numbers, it seems that in older patients, extrapancreatic SPT with malignant behaviors seems to have a poor prognosis ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

Radiologic Findings in Extrapancreatic Solid Pseudopapillary Tumor with Aggressive Behavior: a Case Report

et al. 2017

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Solid pseudopapillary tumor (SPT) is a low grade malignant tumor in the pancreas, and extrapancreatic SPT is extremely rare. We report a case of a 61-year-old woman who complained abdominal pain with diffuse tenderness. She was diagnosed with extrapancreatic SPT with extensive peritoneal dissemination and hepatic metastases. Although a few cases have reported imaging findings of extrapancreatic SPT, there have been no reports of extrapancreatic SPT with aggressive tumor behavior and dismal prognosis. Although imaging features closely resembled those of classical pancreatic SPTs, malignant transformation of extrapancreatic SPT should be considered when focal discontinuity of the tumor capsule with ill-defined margin and invasion of adjacent structures were identified.

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Section: Discussionmentioning

confidence: 99%

Radiologic Findings in Extrapancreatic Solid Pseudopapillary Tumor with Aggressive Behavior: a Case Report

et al. 2017

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“…Solid pseudopapillary tumors of low malignant potential usually occur in the pancreas, and predominantly affect young females in their second or third decade of life (14). They occasionally occur in children (2,14) and older females (13) or males (6). A review of 718 well-documented cases of pancreatic SPTs by Papavramidis et al (15) reported a male-to-female ratio of 1:9.78, with a mean age of 21.97 years (range, 2-85 years).…”

Section: Discussionmentioning

confidence: 99%

“…The authors indicated that unusual pathological features, including solid and diffuse growth patterns with extensive tumor necrosis and a high mitotic rate, may predict aggressiveness and clinical outcomes. Only three extrapancreatic SPTs that were associated with malignant behavior and resulted in metastasis have previously been reported (9,11,13). They exhibited an increased N/C ratio, hyperchromasia, greater nuclear atypia and pleomorphism.…”

Section: Discussionmentioning

confidence: 99%

“…However, SPTs also have a low potential for malignancy, and carry a 6-15% rate of recurrence or metastasis (5), with the liver being the most common metastatic site. There have been scattered reports of SPTs arising in extrapancreatic sites, including the retroperitoneum (1,6,7), omentum (8,9), ovary (10)(11)(12) and gastroduodenal area (13). The most common extrapancreatic site is the mesocolon or omentum (1).…”

Section: Introductionmentioning

confidence: 99%

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Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases

Guo

Ren

et al. 2016

Molecular and Clinical Oncology

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Solid pseudopapillary tumors (SPTs) are unusual neoplasms that mostly occur in the pancreas, and predominantly affect young women. As a low-grade malignant neoplasm of the exocrine pancreas, they occasionally metastasize, usually to the liver or peritoneum. It has been reported that <1% of SPTs are primary extrapancreatic SPTs. In the present study, we present two rare, but conspicuous extrapancreatic SPTs. Both occurred in young women, and showed good prognoses following surgery. One was a recurrent SPT of the pancreas that metastasized to the ovary, and the other was a distinct primary neoplasm that arose in the retroperitoneal area. The pathological features of the two tumors, including solid and pseudopapillary growth patterns with pale or eosinophilic cytoplasm, were characteristic of SPTs of the pancreas. However, in the case of the metastatic ovarian tumor, focal necrosis and an increased nuclear-to-cytoplasmic ratio were observed. The presence of positive nuclear-cytoplasmic β-catenin, the loss of membranous E-cadherin expression, and a perinuclear punctate CD99 staining pattern on immunohistochemistical analysis, were essential features for diagnosis. The aim of the present study was to compare the morphological and immunohistochemical features of these tumors with those typical of pancreatic SPTs, and to raise awareness that SPTs are able to metastasize to unusual sites, and may also arise as primary tumors outside the pancreas, which may lead to diagnostic dilemmas. Case reports Clinical features Case 1. A 22-year-old woman presented at the Emergency Department of our hospital with sudden abdominal pain; two years previously, the patient had been diagnosed with a pancreatic SPT that had extensively metastasized into the abdominal cavity. A review of her medical history revealed that the patient

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“…Despite the diverse studies using electron microscopy and immunohistochemistry (IH), the cellular origin of this tumor remains uncertain, and it is hypothetically suggested that its ontogeny is of a multipotential primitive cell [12,13]. Some authors [14] have suggested an extra-pancreatic origin due to the several reported cases of the primary tumor at different sites, such as ectopic pancreas [15], retroperitoneum [16], gastroduodenal area [17], and ovary [18,19].…”

Section: Introductionmentioning

confidence: 99%

A Molecular Study of Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient

et al. 2018

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Solid pseudopapillary neoplasm of the pancreas (SPNP) is considered as a tumor with low malignant potential. Little is known about how its molecular heterogeneity is involved in its pathogenesis. We aim to evaluate tumor heterogeneity by immunohistochemistry (IH) and proteomics in three macroscopically distinct areas. Tumor fragments were obtained from a 12-year-old female patient. We identified by mass spectrometry (MS) 1,427, 5,786, and 4,298 proteins for each sample, 1,337 being common to all fragments. Several MS results were immunohistochemically validated. Our results demonstrate unique intra-tumor protein profiles based on its heterogeneity.

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Primary malignant solid pseudopapillary tumors of the gastroduodenal area

Cited by 19 publications

References 25 publications

Radiologic Findings in Extrapancreatic Solid Pseudopapillary Tumor with Aggressive Behavior: a Case Report

Radiologic Findings in Extrapancreatic Solid Pseudopapillary Tumor with Aggressive Behavior: a Case Report

Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases

A Molecular Study of Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient

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