Primary malignant non-Hodgkin's lymphoma of cranial vault: A case report

Parekh, Harshad C.; Sharma, Rewati Raman; Keogh, A. J.; Prabhu, Sujit S.

doi:10.1016/0090-3019(93)90007-n

Cited by 43 publications

(36 citation statements)

References 11 publications

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“…Other findings such as cortical disruption, pathological fractures or soft tissue masses, can also be present but are difficult to detect with this technique (7,9,12,14,16,23,25). Differential diagnosis should be made at this point with metastatic disease of the affected bone (5,11).…”

Section: Undabeitia J Et Al: Primary Bone Non-hodgkin Lymphoma Of Thmentioning

confidence: 99%

“…After the neuroimaging study is complete, the differential diagnosis should include entities such as lymphoma, plasmacytoma, metastases, myeloma and osteomyelitis, which are usually associated with destruction of the bone (2,14,16). Once the diagnosis of diffuse large-B-cell lymphoma is established, polyostotic, metastatic or regional lymphatic disease involvement should be discarded (11).…”

Section: Undabeitia J Et Al: Primary Bone Non-hodgkin Lymphoma Of Thmentioning

confidence: 99%

“…The most common locations for PBL are reported to be the femur or the pelvis (50%) and the long bones of the upper limbs (20%) with the remaining 30% occurring in other locations such as the ribs, mandible or scapula (14,16). A primary vertebral location accounts only for 1.7% of all PBLs (1), usually at the thoracic or lumbar levels, while a cervical location remains an exceptional event (23).…”

Section: Introductionmentioning

confidence: 99%

“…While bone involvement is a common complication in advanced stage lymphomas, primary bone lymphoma (PBL) is a rare disease, accounting for approximately 3% of malignant bone tumours, less than 2% of all lymphomas and less than 5% of extranodal lymphomas in adults (3,5,7,12,16,19,21). The most common locations for PBL are reported to be the femur or the pelvis (50%) and the long bones of the upper limbs (20%) with the remaining 30% occurring in other locations such as the ribs, mandible or scapula (14,16).…”

Section: Introductionmentioning

confidence: 99%

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Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Undabeitia¹,

Noboa²,

Boix³

et al. 2013

Turkish Neurosurgery

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Primary bone lymphomas (PBL) account for approximately 3% of all malignant tumors and are commonly found in the femur or pelvis. Only 1.7% of the PBLs are found in the spine. We report the case of a 73-year-old male complaining of cervical pain with progressive loss of strength and frequent falls. The MRI showed invasion of the fourth cervical vertebra and an infiltrating prevertebral mass. A C4 corpectomy was performed. The pathology exam revealed a diffuse large B-cell lymphoma. Due to the previous condition of the patient only radiotherapy treatment was applied. PBL arising from the cervical spine is an exceptional event. The low incidence of this condition and its unspecific radiological features make the diagnosis challenging for the clinician. When neurological deficit appears, early surgery for decompression is indicated, followed by local radiotherapy and systemic chemotherapy. KEywoRds: Non Hodgkin lymphoma, Cervical vertebrae, Diffuse large B-cell lymphoma ÖZPrimer kemik lenfomaları (PKL) tüm malign tümörlerin yaklaşık %3'ünü oluşturur ve sıklıkla femur veya pelviste bulunur. PKL'lerin sadece %1,7'si omurgada bulunur. Servikal ağrı, giderek azalan güç ve sık düşmelerden yakınan 73 yaşında bir erkek olguyu sunuyoruz. MRG dördüncü servikal vertebra invazyonu ve bir infiltratif prevertebral kitle gösterdi. C4 korpektomi yapıldı. Patoloji incelemesi difüz büyük B hücreli lenfoma olarak rapor edildi. Hastanın önceki durumu nedeniyle sadece radyoterapi tedavisi uygulandı. Servikal omurgadan köken alan PKL çok nadirdir. Bu hastalığın insidansının düşüklüğü ve spesifik olmayan radyolojik özellikleri tanıyı klinisyen için zor hale getirir. Nörolojik defisit belirdiğinde, dekompresyon için erken cerrahi endikedir ve sonrasında lokal radyoterapi ve sistemik kemoterapi uygulanır.ANAHTAR sÖZCÜKLER: Non Hodgkin lenfoma, Servikal vertebra, Diffüz büyük B hücreli lenfoma

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Section: Undabeitia J Et Al: Primary Bone Non-hodgkin Lymphoma Of Thmentioning

confidence: 99%

Section: Undabeitia J Et Al: Primary Bone Non-hodgkin Lymphoma Of Thmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Undabeitia¹,

Noboa²,

Boix³

et al. 2013

Turkish Neurosurgery

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show abstract

“…Although transcalvarial lymphoma is a recognised phenomenon, [1][2][3][4][5] this case is unique because of the size of the lesion. It is impossible to determine whether the lymphoma arose from the brain or from the calvarial bone-all previous reports describe primary bone disease spreading into the brain.…”

Section: Discussionmentioning

confidence: 99%

Massive transcalvarial lymphoma

Uff

Shieff

2006

Journal of Neurology, Neurosurgery & Psychiatry

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Bulky centroblastic non-Hodgkin's lymphoma of the cranium vault mimicking brain involvement managed with chemotherapy. A case report

Landys¹,

Berg²,

Torgerson³

et al. 1995

Cancer

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Background. Patients with central nervous system (CNS) involvement by high grade non‐Hodgkin's lymphoma (NHL) have a poor prognosis. The roles of computed tomography, radiotherapy, and intrathecal and systemic chemotherapy still need to be defined. Methods. A patient with bulky cranial lymphoma mimicking brain involvement is reported. A 62‐year‐old man was admitted with a huge scalp lump, headache, fatigue, and focal and generalized neurologic symptoms. Computed tomography showed an abnormal mass in the frontoparietal region involving the subcutaneous scalp, osteolytic destruction of the cranial vault, and a bulky mass that was interpreted to be intracranial. A systemic survey also revealed bulky retroperitoneal involvement and focal involvement of the spleen. Biopsy revealed a B‐cell NHL of centroblastic type according to the Kiel classification. Results. The patient was treated with a modified combination of cyclophosphamide plus mitoxantrone plus vincristine plus prednisone (CNOP) and intrathecal methotrexate. The patient responded with complete remission, including partial bone restoration of the cranium. At the time of this writing, his relapse free survival lasted 5 years. Conclusions. The initial interpretation of this case indicated that systemic chemotherapy with modified CNOP plus intrathecal methotrexate would be useful in the management of NHL with CNS involvement. The clinical outcome with rapid neurologic repair and also bone restoration of the cranial vault within 5 years suggests that the lymphoma probably never penetrated the dura and a successful treatment was achieved with combination chemotherapy only.

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Primary malignant non-Hodgkin's lymphoma of cranial vault: A case report

Cited by 43 publications

References 11 publications

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Massive transcalvarial lymphoma

Bulky centroblastic non-Hodgkin's lymphoma of the cranium vault mimicking brain involvement managed with chemotherapy. A case report

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