Primary malignant melanoma of the urethra: a systematic analysis of the current literature

El‐Safadi, Samer; Estel, Rebecca; Mayser, Peter; Muenstedt, Karsten

doi:10.1007/s00404-013-3130-3

Cited by 56 publications

(85 citation statements)

References 65 publications

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“…Unfortunately, most reported cases have resulted in death, with a median survival of 28.6 months after diagnosis. 4 Our patient, now 14 months postdiagnosis, is receiving chemotherapy for his metastatic disease.…”

Section: Discussionmentioning

confidence: 97%

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Primary malignant melanoma of the urethra detected by urine cytology in a male patient

DeSimone

Hoda

2015

Diagnostic Cytopathology

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Dear Editor:We read with interest the recent article by Hori et al. describing primary bladder melanoma diagnosed on voided urine cytology.1 Herein, we present a case of primary urethral melanoma diagnosed as suspicious for melanoma on voided urine cytology. To our knowledge, there have been rare case reports of primary bladder melanoma and one report of a primary urethral melanoma detected by urine cytology. 1-3 CaseThe patient was an 81-year-old man who presented to his urologist with benign prostatic hyperplasia and bladder outlet obstruction in the setting of a long history of lower urinary tract symptoms and hematuria for several months. Bladder outlet obstruction was demonstrated on urodynamics and attributed to an enlarged prostate. To evaluate for malignancy, voided urine was submitted and prepared as one Papanicolaou (Pap)-stained ThinPrepV R (TP) slide (Hologic, Boxborough, MA). Two prior voided urine specimens prepared similarly were negative for malignant cells over the prior 7 months. On microscopic examination, there were scattered large abnormal cells occurring singly and in small clusters (Figs. 1 and 2). The cells had enlarged nuclei, high nuclear-to-cytoplasmic (N/C) ratios, and prominent nucleoli. Several of the cells were bi-and multi-nucleate, and many contained dark-brown cytoplasmic pigment. The findings were suspicious for melanoma.A biopsy of the penile urethra performed 5 months later was diagnosed as melanoma (Fig. 3), confirmed by positive immunostaining for S100, HMB-45, and Melan-A, and negative pancytokeratin. A subsequent right axillary lymph node biopsy revealed metastatic melanoma.

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Section: Discussionmentioning

confidence: 97%

“…4 The majority of urethral melanomas are pigmented. 5 There have been over 160 cases of primary urethral melanoma described in the English literature; the distal urethra is most commonly involved.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the urethra detected by urine cytology in a male patient

DeSimone

Hoda

2015

Diagnostic Cytopathology

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“…The majority of patients will develop recurrence, and most of the patients do not survive more than 3 years. 5 Although surgery is still the first line of treatment, its poor outcomes call into question the oncologic soundness of this therapy for some patients. According the European Society for Medical Oncology guidelines for the treatment of cutaneous melanoma, radiotherapy should be considered after inadequate surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Penis-Preserving Surgery for Urethral Melanoma: Proposal for a Therapeutic Algorithm

Fahmy

Scharpf

Fend

et al. 2015

Clinical Genitourinary Cancer

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“…Malignant urethral melanoma is three times as common in females as in males and is more frequent in the Caucasian population. Most cases are diagnosed after 50 years of age [1,11], with an average age of 64 years [12]. Presenting symptoms include vaginal bleeding, masses, hematuria and dysuria with a decreased urinary stream [13].…”

Section: Discussionmentioning

confidence: 99%

“…In this case, we found inguinal lymph node metastasis 16 months after surgery. However, no further recurrence was noted following resection of the metastatic lymph nodes, although recurrence of urethral melanoma has been reported to occur within 12.5 months [12].…”

Section: Authors' Contributions Nk Kn As Ts MM Fe Hk Kh Nw Tn Ty Ttmentioning

confidence: 94%

Primary malignant melanoma of the female urethra: a rare case of cytological observation

Kawaguchi¹,

Nambu²,

Sekiya³

et al. 2014

Pathol Discov

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We herein report a rare case of primary malignant urethral melanoma developed in an elderly Japanese patient with hypertension, diabetes and hyperlipidemia. An 80-year-old female presented at our hospital with a history of urodynia and perineal pain lasting for several months. Cystoscopy revealed cystitis and urethritis with erosion. At that time, urinary cytology was negative for malignancy, although melanophages were observed. Four months later, lower abdominal computed tomography and magnetic resonance imaging indicated urethral tumors. Urinary cytology subsequently detected malignant melanoma, and a biopsy of the urethra confirmed malignancy. Although inguinal lymph node metastasis was found 16 months postoperatively, the patient has remained free of disease for more than six years after surgery and chemotherapy.

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Primary malignant melanoma of the urethra: a systematic analysis of the current literature

Cited by 56 publications

References 65 publications

Primary malignant melanoma of the urethra detected by urine cytology in a male patient

Primary malignant melanoma of the urethra detected by urine cytology in a male patient

Feasibility of Penis-Preserving Surgery for Urethral Melanoma: Proposal for a Therapeutic Algorithm

Primary malignant melanoma of the female urethra: a rare case of cytological observation

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