Primary Malignant Melanoma Of The Parotid Gland Combined 18F-FDGPET/CT And Immunochemical Diagnosis With Literature Review

Darouichi, M.

doi:10.14302/issn.2574-4526.jddd-16-1322

Cited by 4 publications

(10 citation statements)

References 12 publications

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“…Radiologically, both head-and-neck CT scan and MRI of AMM usually presented as an intra-parotid mass with an undefined, obscure boundary with focal necrotic centers. [ 1 4 ] Axial view of MRI of the present case was also showing a large, solid mass involving superficial and deep lobe of left parotid along with submandibular salivary gland without any bony abnormality, suggestive of malignancy involving the parotid and submandibular salivary gland.…”

Section: Discussionmentioning

confidence: 60%

“…Green and Bernier (1961) published several criteria for the diagnosis of primary parotid MM (PPMM)[ 1 11 ] and in 1993, Woodward (WW's criteria) coined some criteria for the same, such as (i) The predominant tumor mass should be intra-parotid; (ii) there should be no identifiable lymph node tissue present in the mass; (iii) there should be no evidence of MM elsewhere after a diligent search of the eyes, skin, nose, pharynx, mouth, esophagus, anogenital region and meninges and (iv) there should be no evidence of the previous excision of a MM or progressing pigmented lesion. [ 3 4 11 12 ] Furthermore, later in 1997, Takada found melanocytes for the very first time in interlobular duct of the parotid gland in a Japanese male during performing autopsy. [ 3 13 ]…”

Section: Discussionmentioning

confidence: 99%

“…Fine-needle aspiration cytology (FNAC) can be a noninvasive and helpful procedure for diagnosis; however, its utility remains controversial. [ 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

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Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report

Sultana

Chatterjee

Kundu

et al. 2022

J Oral Maxillofac Pathol

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report

Sultana

Chatterjee

Kundu

et al. 2022

J Oral Maxillofac Pathol

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“…These original sites may include the scalp, mucosa membranes of the nose, paranasal sinuses, and throat. The 2 sources of metastasis include intra-lymphatic spread and direct melanoma extension from adjacent soft tissue (2).…”

Section: Discussionmentioning

confidence: 99%

“…They mostly occur as metastases originating from cutaneous or mucous sites of the head and neck region. As there is a delay in diagnosis of this entity, the prognosis is poor and the pathogenesis is controversial (1,2). Some malignant melanomas may metastasize and regress, so the metastasis and its primary source are not simultaneously identified.…”

Section: Introductionmentioning

confidence: 99%

Malignant Melanoma Presenting as a Parotid Mass in a Middle-aged Woman with Metastasis to the Breast

et al. 2021

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Introduction: Malignant melanomas of the parotid gland are relatively uncommon and usually seen as metastases from cutaneous or mucous sites of the head and neck region. Some malignant melanomas may metastasize before they regress. Therefore, identifying the primary origin of metastatic melanoma is sometimes difficult. Furthermore, metastasis to the breast from an extramammary site is uncommon and challenging. It may present as a well-defined rounded mass that histopathologically mimics the various architecture and cellular phenotypes. In addition, the immunohistochemical stains of some metastatic melanomas are equivocal and challenging. Case Presentation: We presented a case of parotid gland malignant melanoma in a 42-year-old woman with metastasis to the breast in a short interval. Biopsy of parotid and breast lesions showed loss of immune-reactivity for several melanoma markers and was initially considered as malignant peripheral nerve sheath tumor and primary breast tumor, respectively. Conclusions: This case highlights the importance of obtaining past clinical history in surgical pathology cases to make a correct diagnosis. It also enhances our understanding regarding malignant melanoma as a mysterious tumor with various morphology and immunophenotype.

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Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Klijanienko,

Masliah-Planchon,

Choussy

et al. 2024

Acta Cytologica

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Introduction: Poorly differentiated primary sarcomatoid parotid malignancies are extremely rare. These tumors have not been consistently studied by morphology, immunohistochemistry, or molecular techniques. Case Presentation: We report three unusual cases of parotid gland poorly-differentiated sarcomatoid malignancy investigated by fine-needle aspiration and studied histologically, by immunohistochemistry and molecular investigations. Aspirates showed poorly specific polymorphous sarcomatoid malignancy in all cases. Histologically, all cases were polymorphous high-grade malignancies, and additionally, one case showed epithelial structures and was finally classified as salivary carcinosarcoma. Immunohistochemistry showed classical melanocytic markers negativity but positivity for PRAME, CD10, and WT1 in all three tumors and for CD56 in two tumors, which can potentially be supportive of melanocytic origin. Although not entirely specific, molecular characterization also suggested the melanocytic lineage of these tumors. Conclusion: Although rare, primary malignant melanoma of salivary gland was already described, but undifferentiated/dedifferentiated amelanotic forms are unknown in this localization up today. Further case reports of similar presentations are required to confirm the unequivocal primary origin of these obscure neoplasms in the parotid gland.

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Primary Malignant Melanoma Of The Parotid Gland Combined 18F-FDGPET/CT And Immunochemical Diagnosis With Literature Review

Cited by 4 publications

References 12 publications

Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report

Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report

Malignant Melanoma Presenting as a Parotid Mass in a Middle-aged Woman with Metastasis to the Breast

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

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