Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report

Sultana, Mehebuba; Chatterjee, Rudra Prasad; Kundu, S. S.; Mahmud, Sk Abdul

doi:10.4103/jomfp.jomfp_183_21

Cited by 3 publications

(5 citation statements)

References 12 publications

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“…Several cases of primary melanoma of the salivary glands have been already published. Critical analysis of this literature has not provided convincing evidence that all previous cases were of primary nature [20,[26][27][28][29][30][31][32][33][34][35]. The main arguments have been the lack of immunohistochemistry in older publications (especially in amelanotic forms) or the lack of a systematical search for a potential primary tumor elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Klijanienko,

Masliah-Planchon,

Choussy

et al. 2024

Acta Cytologica

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Introduction: Poorly differentiated primary sarcomatoid parotid malignancies are extremely rare. These tumors have not been consistently studied by morphology, immunohistochemistry, or molecular techniques. Case Presentation: We report three unusual cases of parotid gland poorly-differentiated sarcomatoid malignancy investigated by fine-needle aspiration and studied histologically, by immunohistochemistry and molecular investigations. Aspirates showed poorly specific polymorphous sarcomatoid malignancy in all cases. Histologically, all cases were polymorphous high-grade malignancies, and additionally, one case showed epithelial structures and was finally classified as salivary carcinosarcoma. Immunohistochemistry showed classical melanocytic markers negativity but positivity for PRAME, CD10, and WT1 in all three tumors and for CD56 in two tumors, which can potentially be supportive of melanocytic origin. Although not entirely specific, molecular characterization also suggested the melanocytic lineage of these tumors. Conclusion: Although rare, primary malignant melanoma of salivary gland was already described, but undifferentiated/dedifferentiated amelanotic forms are unknown in this localization up today. Further case reports of similar presentations are required to confirm the unequivocal primary origin of these obscure neoplasms in the parotid gland.

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Section: Discussionmentioning

confidence: 99%

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Klijanienko,

Masliah-Planchon,

Choussy

et al. 2024

Acta Cytologica

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“…Melanomas of the submandibular and the parotid gland are usually metastatic of a CM as these glands are known to be filtering centers for lymphatic drainage of the head and neck area. 4 However, a few cases of PMSGs have been described in the literature. 4 , 5 …”

Section: Discussionmentioning

confidence: 99%

“… 5 Therefore, the predominant tumor mass should be intraglandular; with no evidence of lymph node tissue present in the mass and no evidence of melanoma in other locations. 4 …”

Section: Discussionmentioning

confidence: 99%

“…In primary melanoma of the parotid and the submandibular gland, regional and distant metastases are common. 4 …”

Section: Discussionmentioning

confidence: 99%

“… 1 – 3 The majority of PMMs (41%–55%) occur in the head and neck region. 4 The most common sites of PMMs of the head and neck are the nasal cavity, the paranasal sinuses, and the oral cavity. 1 PSGMs are extremely rare and only a few cases have been described in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Primary non-cutaneous melanomas of the head and neck: Case series and review of the literature

Thabet,

Zitouni,

Chebil

et al. 2024

SAGE Open Medical Case Reports

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Primary non-cutaneous melanoma is a rare type of melanoma that occurs mostly on mucosal surfaces. The head and neck region is the most common site for these melanomas. The following cases described herein include patients diagnosed with primary non-cutaneous melanomas. The locations included the parotid gland (one case), the submandibular gland (one case), and the nasal cavity and paranasal sinuses (three cases). Among these patients, one patient developed lymph node metastasis and one patient had distant metastasis. Treatment included endoscopic surgery (one case), endoscopic surgery with adjuvant radiotherapy (one case), open surgery (one case), and palliative chemotherapy (one case). One patient refused to receive treatment. After treatment, one patient had local recurrence. A local and distant recurrence was noted in one case. This report aims to describe clinical features, treatment options, and prognosis of primary non-cutaneous melanomas of the head and neck.

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Primary Malignant Melanoma in the Parotid Gland: A Case Report and Literature Review

Yan,

Duan,

et al. 2024

Ear Nose Throat J

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Primary melanoma of the parotid gland is an extremely rare and challenging tumor with a poor prognosis, and its ultrasonic characteristics have yet to be reported. This article presents a case of a 77-year-old man with a left parotid mass that was confirmed as a melanoma following surgery. The ultrasonic features of melanoma were examined in detail, with a particular focus on their diagnostic value. Furthermore, we summarized the clinical characteristics, treatment options, and outcomes associated with primary melanoma of the parotid gland based on a thorough analysis of the available literature.

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Primary amelanotic malignant melanoma of parotid and submandibular salivary gland: A rare case report

Cited by 3 publications

References 12 publications

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Primary non-cutaneous melanomas of the head and neck: Case series and review of the literature

Primary Malignant Melanoma in the Parotid Gland: A Case Report and Literature Review

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