Primary malignant fibrous histiocytoma of the mandible: review of literature and report of a case

Benign Fibrous Histiocytoma: A Rare Case Report and Literature Review

“…In the soft tissues of the oral cavity the principal lesion that requires a differential histological diagnosis from BFH is malignant fibrous hystiocitoma (MFH). Histological pattern of MFH is important: the high pleomorphism of the cells, the high mitotic activity, more than 5 per 10 high power fields and infiltration of the capsule and into the surrounding tissue are present in MFH [6]. In the case presented, the neoplasm was clearly defined on clinical analysis and there were no signs of local invasion, though involvement of underlying cortical plate created some doubt but histological absence of any significant mitotic activity cleared the picture.…”

“…However, at clinical level, the differential diagnosis with other soft tissue neoplasms is not possible. Histological examination as rare mitosis, absence of cellular atypia, presence of histiocytes and chronic inflammatory cell infiltrate with hyalinization and myxoid changes makes the diagnosis more clear [1,5,6]. The differential histological diagnosis includes neurofibroma, leomyosarcoma and dermatofibroma, so-called atypical-BFH [12].…”

“…With the evolution of various latest immunohistochemical techniques and electron microscopy, discrimination between malignant and benign forms can be done easily. This has resulted in establishing benign fibrous histiocytoma (BFH) as a separate clinical entity, although many synonyms are still used [4][5][6]. Nowadays, BFH is included in the so-called ''fibrohistiocytic tumours of the soft tissues'' that are divided into cutaneous and non-cutaneous types, and in the ''fibrohistiocytic tumours of the bone'' [1,4,5,7].…”

Oral fibrous histiocytoma and its angiomatoid variant

“…These histiocytic cells were positive for lysozyme which has been used as immunohistochemical marker to test and prove the histiocytic origin of tumour (Kanazawa et al, 2003). Microscopic examination revealed a clear boundary between this lesion and the surrounding tissues.…”

Head and Neck Soft Tissue Sarcoma

“…The rarer symptoms include infraorbital nerve paresthesia, visual disturbance, and ocular proptosis. In cases of MFH of the mandible, Kanazawa et al [Kanazawa H et al, 2003]. reported in their review that those lesions are usually first noticed due to swelling, paresthesia, and loosening of teeth.…”